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Bifidobacterium lungum rapo strain for alleviation, prevention, or treatment of rheumatoid arthritis and composition comprising same

一种长双歧杆菌、类风湿性的技术，应用在双歧杆菌、食品制备中使用的细菌、药物组合等方向，能够解决不能抑制疾病发展、用作有效的治疗方法限制、胃肠障碍等问题

Active Publication Date: 2020-11-06
BEAFED GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NSAIDs and steroids are known to alleviate disease symptoms by reducing inflammation but do not inhibit disease progression
The above-mentioned medicines have problems such as gastrointestinal disorders and side effects due to long-term administration, so their use as effective therapeutic methods is limited

Method used

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  • Bifidobacterium lungum rapo strain for alleviation, prevention, or treatment of rheumatoid arthritis and composition comprising same
  • Bifidobacterium lungum rapo strain for alleviation, prevention, or treatment of rheumatoid arthritis and composition comprising same
  • Bifidobacterium lungum rapo strain for alleviation, prevention, or treatment of rheumatoid arthritis and composition comprising same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Detection of Bifidobacterium longum RAPO (Bifidobacterium longum RAPO) (Deposit Number: KCTC13773BP)

[0036] In 80% of patients with rheumatoid arthritis, rheumatoid factor (RF), which is one of autoantibodies present in the Fc site of IgG, is found. Therefore, in this example, according to the existence and degree of rheumatoid factors, the distribution of intestinal flora is analyzed at the Phylum level and Genus level to detect microorganisms that have an effect on rheumatoid arthritis .

[0037] 1) Sample preparation and analysis method

[0038] In order to analyze the distribution of microbiome according to the rheumatoid factor (Rheumatoid factor, RF) found in 80% of rheumatoid arthritis patients as an autoantibody, 17 patients with rheumatoid arthritis aged 40-59 years 1 rheumatoid factor negative (RF negative) (0-20) patients, 24 low positive (Low positive) (2060) patients were collected as objects Fecal samples were stored at -80°C. Rheumatoid f...

experiment example 1

[0049] Experimental example 1: Confirmation of the disease inhibitory effect of Bifidobacterium longum RAPO (Bifidobacterium longum RAPO) (Accession No.: KCTC13773BP) on rheumatoid arthritis

[0050] In this experimental example, in order to evaluate the effect of Bifidobacterium longum RAPO (Bifidobacterium longum RAPO) of the above-mentioned embodiment 1 on rheumatoid arthritis disease, type II collagen (type II collagen, CII) and Complete Freund's adjuvant (complete Freund's adjuvant, CFA) was injected into the tail of each DBA / 1J mouse with 100 μg / 50 μl of CII. Two weeks later, arthritic animals were produced with a second injection of a 1:1 mixture of 100 μg / 50 μl. Oral administration of 50 mg / kg Bifidobacterium longum RAPO per day was started 3 weeks after the onset of rheumatoid arthritis. For comparison, a rheumatoid arthritis group (vehicle) to which Bifidobacterium longum RAPO was not administered and a group administered methotrexate (MTX) as one of the antirheumat...

experiment example 2

[0052] Experimental Example 2: Confirmation of the inhibitory effect of Bifidobacterium longum RAPO (Bifidobacterium longum RAPO) (Accession No.: KCTC13773BP) on joint tissue destruction in rheumatoid arthritis

[0053] In this experimental example, in order to evaluate the effect of the Bifidobacterium longum RAPO of the above-mentioned Example 1 on the joint tissue of rheumatoid arthritis, the degree of damage to the joint tissue of mice was analyzed. The rheumatoid arthritis group (vehicle) that did not administer Bifidobacterium longum RAPO, the Bifidobacterium longum RAPO administration group at 50 mg / kg, the methotrexate administration group at 3 mg / kg, and the vehicle without induction of arthritis Normal WT (arthritis control group) mice were used as objects, and a normal group (WT), a rheumatoid arthritis group (vehicle) not administered with Bifidobacterium longum RAPO, a methotrexate-administered group (MTX), The Bifidobacterium longum RAPO administration group (B.l...

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Abstract

The present invention relates to novel Bifidobacterium longum RAPO (accession number: KCTC13773BP) and can provide a composition for alleviation, prevention, or treatment of rheumatoid arthritis, thecomposition comprising Bifidobacterium longum RAPO (accession number: KCTC13773BP) selected in the present invention.

Description

technical field [0001] The present invention relates to novel Bifidobacterium longum RAPO (Bifidobacterium longum RAPO) (preservation number: KCTC13773BP), in more detail, relates to longum Bifidobacterium RAPO (Bifidobacterium longum RAPO) (preservation number: KCTC13773BP) and a method for improving, A composition for treating or preventing rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid arthritis) is a chronic inflammatory disease of unknown etiology characterized by polyarthritis. Initially, inflammation occurs in the synovium surrounding the joint, but the inflammation gradually spreads to the surrounding cartilage and bone, resulting in Destruction and deformation of joints. Moreover, not only the joints are destroyed, but also symptoms other than the joints, such as anemia, Sjogren's syndrome, subcutaneous nodules, pulmonary fibrosis, vasculitis, skin ulcers and other serious systemic diseases appear. [0003] Drugs for rheumatoi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A23L33/135A61K35/745A61P19/02A61P29/00C12R1/01
CPCC12N1/205C12R2001/01A61P19/02A61K35/745A23L33/135A23V2002/00C12N1/20A23V2200/306A23V2400/533A61P29/00
Inventor 池根亿郑闰宙朴相俊梁洙英李炫河朴盛焕曹美罗朱址贤郭丞基李周河金智媛李善瑛柳俊杰田周燕柳在润
Owner BEAFED GMBH
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