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A traditional Chinese medicine composition capable of preventing and/or treating dysmenorrhea and its preparation method and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and preparation thereof, can solve problems such as unsuitability for long-term use, inability to use dysmenorrhea, toxic and side effects of safflower, achieve good analgesic therapeutic effect, low in vivo toxicity, and concise and reasonable prescription Effect

Active Publication Date: 2022-04-19
赵瑞华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the efficacy of angelica, notoginseng, safflower and rose and their usage and dosage in patent CN102488763A, the traditional Chinese medicine composition disclosed by patent CN102488763A is composed of four herbs such as angelica, notoginseng, safflower and rose. For qi stagnation and blood stasis type dysmenorrhea, not for other types of dysmenorrhea
In addition, safflower is used in the Chinese medicine composition, and safflower has certain toxic and side effects, which leads to the defect that the Chinese medicine composition is not suitable for long-term use.

Method used

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  • A traditional Chinese medicine composition capable of preventing and/or treating dysmenorrhea and its preparation method and application
  • A traditional Chinese medicine composition capable of preventing and/or treating dysmenorrhea and its preparation method and application
  • A traditional Chinese medicine composition capable of preventing and/or treating dysmenorrhea and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Preparation of traditional Chinese medicine compositions

[0045] Take 0.6kg of galangal, 0.8kg of bergamot, 0.8kg of roses, 0.3kg of 377, crush into the coarsest powder, mix evenly. The first time added 12.5L of water decoction for 1.5h, the second time added 10L of water decoction for 1h, the third time added 10L of water decoction for 0.5h, a total of 3 times of decoction, combined decoction solution, let stand to 50 ° C, the liquid was concentrated and dried under reduced pressure to obtain an extract of 309g (yield of 12.36%), after crushing through a 100 mesh sieve to obtain the powder, that is, the composition of the traditional Chinese medicine.

Embodiment 2

[0046] Example 2 Preparation of traditional Chinese medicine compositions

[0047] Take 1.8kg of galangal, 2.5kg of bergamot, 2.5kg of roses, 1.2kg of sanchi, crush into the coarsest powder, mix well. The first time added 50L of water decoction for 1.5h, the second time added 40L of water decoction for 1.5h, the third time added 35L of water decoction for 1h, a total of 3 times of decoction, combined decoction liquid, standing to 60 ° C, the liquid of the drug was concentrated and dried under reduced pressure to obtain an extract of 1.072kg (yield of 13.4%), after crushing through a 100 mesh sieve to obtain the powder, that is, the composition of traditional Chinese medicine.

Embodiment 3

[0048] Example 3 of the acute toxicity test in mice

[0049] Animals: 40 Kunming mice, weighing 18 to 22g, male and female, purchased from Guangdong Provincial Medical Laboratory Animal Center.

[0050] Pharmaceuticals: The Chinese medicine composition is a Chinese medicine composition prepared from Example 1.

[0051] Experimental method: Kunming mice were randomly divided into experimental group (dose of kilogram body weight 20g) and negative control group (1g / dL carboxymethyl cellulose), 20 in each group, male and female halves. Mice were gasserized twice, with an interval of 2 h, observed for 7 days, and recorded the symptoms and death of animal poisoning.

[0052] Experimental results: During the trial, neither group of mice showed significant symptoms nor died. The Chinese herbal compositions of the present invention to male and female mice via oral LD 50 Each kilogram of body weight is greater than 20 g, according to the classification of acute toxicity, the subject is a no...

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PUM

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Abstract

The invention relates to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3-9 parts of galangal, 4-12 parts of bergamot, 4-12 parts of rose, and 1-5 parts of Panax notoginseng. The Chinese medicine composition is obtained by the inventor through years of clinical experience exploration and summarization according to the theory of traditional Chinese medicine, and has been analyzed, researched and verified. The prescription is reasonable, the medicinal taste is less but refined, the preparation method is simple, and the medicine is convenient to take. It is proved by pharmacodynamic experiments that it has a good therapeutic effect on dysmenorrhea.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition and preparation method and application thereof. Background [0002] Dysmenorrhea refers to pain and swelling in the lower abdomen before and after menstruation or during menstruation, accompanied by waist pain or other discomfort, which can extend to the sacral lower back and even involve the thighs and feet. Every time with the menstrual cycle, severe cases can be accompanied by nausea and vomiting, cold sweat, which seriously affects the quality of life. Dysmenorrhea is divided into two categories: primary dysmenorrhea and secondary dysmenorrhea, primary dysmenorrhea refers to dysmenorrhea without organic lesions of the reproductive organs, generally occurs after the onset of menarche or menarche 6 to 24 months, and the pain lasts for 8 to 72 hours; secondary dysmenorrhea refers to dysmenorrhea caused by pelvic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A23L2/38A23L2/52A23L33/105A61P15/00A61P29/00A61P21/00
CPCA61K36/9062A61K36/752A61K36/738A61K36/258A61P15/00A61P29/00A61P21/00A23L33/105A23L2/38A23L2/52A61K2236/331A61K2236/39A61K2236/53A61K2236/51A23V2002/00A23V2250/21A23V2200/30
Inventor 赵瑞华邹琦范春林李志林
Owner 赵瑞华
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