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Application of ester-containing aromatic propionamide compound in preparation of medicine for treating xerophthalmia

An ester-based aramidamide and compound technology, which is applied in the field of medicine, can solve the problems of no therapeutic effect, toxic and side effects on the ocular surface, etc., and achieve the effects of increasing tear film breakup time, increasing tear secretion, and reducing staining score value.

Active Publication Date: 2020-12-08
CHANGCHUN GENESCIENCE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, artificial tears are only a substitute for tears and have no therapeutic effect in themselves; long-term use of corticosteroids and cyclosporine A and other drugs have certain toxic and side effects on the ocular surface

Method used

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  • Application of ester-containing aromatic propionamide compound in preparation of medicine for treating xerophthalmia
  • Application of ester-containing aromatic propionamide compound in preparation of medicine for treating xerophthalmia
  • Application of ester-containing aromatic propionamide compound in preparation of medicine for treating xerophthalmia

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Experimental program
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Effect test

Embodiment Construction

[0024] The following experiments are used to confirm the effect of the ester group-containing aromatic propionamide compound of the present invention on treating dry eye. The EG compounds mentioned in this article are all ester-containing aromatic propionamide compounds, and EG-12, EG-312, EG-17, and EG-317 are C 22 H 19 F 3 N 4 O 4 , C 22 H 18 F4N 4 O 4 , C 25 H 17 F 3 N 4 O 4 and C 25 H 16 F 4 N 4 O 4 , its specific preparation method and structural formula refer to the content recorded in the patent document with application number 2014103602169.

[0025] 1 Experimental name and experimental purpose

[0026] 1.1 Experiment name

[0027] Improvement effect of EG compounds on castration-induced dry eye in male rabbits

[0028] 1.2 Purpose of the experiment

[0029] Observe the improvement effect of test substances EG-12, EG-312, EG-17, EG-317 on dry eye syndrome caused by castration in male rabbits

[0030] 2 The start and end date of the experiment: Aug...

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Abstract

The invention belongs to the technical field of medicines, and particularly discloses application of an ester-containing aromatic propionamide compound in preparation of a medicine for treating xerophthalmia. The inventor makes related experimental researches. Experiments prove that the ester-containing aromatic propionamide compound provided by the invention can increase the tear secretion of castrated rabbits, reduce the corneal fluorescent staining score, increase the tear film rupture time, and has an obvious improvement effect on experimental xerophthalmia.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of an aromatic propionamide compound containing an ester group in the preparation of a medicine for treating dry eye syndrome. Background technique [0002] Dry eye syndrome refers to the general term for various diseases caused by abnormal tear quality or quantity or abnormal dynamics caused by any reason, resulting in decreased tear film stability, accompanied by ocular discomfort and (or) ocular surface tissue lesions, which can cause Keratoconjunctivitis and can affect vision. In recent years, with the widespread use of computers and smart phones, people spend more time using their eyes, coupled with the influence of bad eye habits, resulting in a significant increase in the incidence of dry eye syndrome. Dry eye has become a global epidemic, and the incidence of dry eye in my country is gradually increasing and tends to be younger. Studies have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/277A61K31/4406A61K9/06A61P27/02A61P5/26
CPCA61K31/277A61K31/4406A61K9/06A61K47/06A61P27/02A61P5/26A61K9/0048A61K31/455A61K31/325A61K31/215
Inventor 朱新法朱然
Owner CHANGCHUN GENESCIENCE PHARM CO LTD
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