Fluorescent encoding microspheres and arrays and preparation method of fluorescent encoding microsphere
A technology for encoding microspheres and microspheres, which can be used in the preparation of microspheres, chemical instruments and methods, microcapsule preparations, etc., and can solve problems such as encoding capacity limitations
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Embodiment 1
[0164] In the encoded microspheres of this embodiment, a group of microsphere carriers used have similar diameters and different internal structures, and the internal structure changes of the microsphere carriers are used as the first dimension of encoding information; wherein the microsphere carriers are mesoporous microspheres , which has a porous structure, and different internal structures may be due to different matrix components, different pore sizes, or different matrix components and pore sizes.
[0165] The selection range of the diameter of the microsphere carrier is 0.2-20 μm, and the preferred range is 3-6 μm. The pore diameter of the microsphere carrier can be selected within the range of 2-100 nm, preferably within the range of 10-60 nm. The matrix components of microsphere carriers include inorganic substances and polymers. Inorganic substances include silica and / or titania. Polymers include polystyrene, polyacrylic acid, polymethyl acrylate, polymethacrylic a...
Embodiment 2
[0255] As mentioned above, according to the preparation method of Example 1, step 5 can be repeated to assemble multiple layers of quantum dots with different central emission wavelengths on the outer surface of the microsphere carrier, thereby further increasing the dimension of the encoding and amplifying the encoding. quantity.
[0256] Similarly, on the basis of the preparation method in Example 1, two or more fluorescent dyes with different central emission wavelengths can also be loaded inside the microsphere carrier. The focus of this embodiment is to further describe in detail the preparation method of encoded microspheres loaded with one or more fluorescent dyes inside the microsphere carrier. The encoded microspheres in this embodiment can be used alone, or this The method of the embodiment is applied in step 2 of the first embodiment, thereby enlarging the encoding dimension of the encoded microspheres in the first embodiment.
[0257] The design of the preparation...
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