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A kind of cu-zn composite intrauterine device and preparation method thereof

An intrauterine device and composite material technology, applied in the field of Cu-Zn composite intrauterine device and its preparation, can solve the problems of user's abdominal discomfort, easy increase of abnormal uterine bleeding, rough corrosion surface, etc., and achieve improved safety. Sexuality and efficacy, improvement of abnormal uterine bleeding, improvement of biocompatibility

Active Publication Date: 2022-07-05
吴江永元生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nearly 141 million women of childbearing age in my country use IUDs for contraception. However, when traditional copper-containing IUDs are implanted into the human uterus, there is a phenomenon of explosive release of copper ions, and excessive copper ions will aggravate the damage and inflammation of endometrial tissue. Cause users to experience side effects such as abdominal discomfort or even pain, increased menstrual blood
The patent (2020105650069) discloses an ultra-fine-grained Cu-Mg alloy intrauterine device, which uses an ultra-fine-grained Cu-Mg alloy as the source of copper ions, and the composition of the ultra-fine-grained Cu-Mg alloy contains 0-1wt. % Mg, can effectively reduce the burst release of copper ions; but the corrosion resistance of the ultra-fine-grained Cu-Mg alloy is average, and the corrosion surface is rough, which is easy to increase the stimulation of IUD to endometrial tissue and cause side effects such as abnormal uterine bleeding

Method used

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  • A kind of cu-zn composite intrauterine device and preparation method thereof
  • A kind of cu-zn composite intrauterine device and preparation method thereof
  • A kind of cu-zn composite intrauterine device and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] According to the composition and proportion of the Cu-Zn composite material, weigh copper powder (≥99.9wt.%) and zinc powder, mix them evenly, and smelt in a vacuum melting furnace at a melting temperature of 1250°C. Scale of Cu-Zn composite ingots of different compositions. Cut the ingot into After annealing at 450 ℃ for 2 hours, the bar is subjected to equal-diameter angular extrusion or continuous extrusion at room temperature, and B is selected. C path, the extrusion speed is 10-20 mm / s, and the extrusion is repeated 4 times or more to obtain a Cu-Zn composite material. As shown in Table 2, Cu-0.01Zn indicates that the weight percentage of Zn in the composite material is 0.01%; Cu-38Zn indicates that the weight percentage of Zn in the composite material is 38%; others are similar.

[0053] Typical Cu-Zn composites and their processing paths, grain size, and copper ion detonation in SUF are shown in Table 2. It can be seen from Table 2 that the explosive release ...

Embodiment 2

[0058] The 100% leaching solution of the Cu-38Zn composite material of the present invention can treat the CCK of uterine-related cells (including human endometrial epithelial cells, human endometrial stromal cells, and human extrachorionic trophoblast cells) after culturing for 1, 2, and 3 days. -8 result ( Figure 5), it can be clearly seen that compared with the negative control group, the cell proliferation rate of pure copper with coarse grains is very low. According to the standard of ISO 10993-5-2009, the cytotoxicity of the material was evaluated, and it was found that the three cytotoxicities of the 100% extract of coarse grains were all at grade IV after culturing for 1, 2, and 3 days. However, the three cytotoxicities of the 100% extract of Cu-38Zn composite material were cultured for 1, 2, and 3 days: human endometrial epithelial cells were grade III, II, and II, and human endometrial stromal cells were II, II, and II, respectively. Grades III and IV, and the cyto...

Embodiment 3

[0060] The Cu-38Zn composite material of the present invention obtains a metal rod with a diameter of 1 mm and a length of 10 mm by using the wire electric discharge cutting or processing method, and one end of the metal rod is polished to a groove for subsequent implantation experiments to fix the material in the uterine cavity. A medical surgical thread was attached, and after ultrasonic cleaning with ethanol and ultraviolet disinfection, the Cu-38Zn composite material was implanted into the uterine cavity unilaterally. It can be seen that embryos were formed on both sides of the uterus of the normal control group (without contraceptive operation); the Cu-38Zn composite material was implanted on the side without embryo formation; the Cu-38Zn composite material was implanted on the opposite side, with complete embryo formation and appearance. No obvious abnormality was found on the above, and there was no significant difference with the normal control group (Figure 7). It can ...

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Abstract

The invention discloses a Cu-Zn composite intrauterine device and a preparation method thereof. The Cu-Zn composite material is used as an active substance source; the Cu-Zn composite material, according to the weight percentage, the weight percentage of Zn is: 0-50wt.%; the weight percentage of Cu is 50-100wt.%. The Cu-Zn composite intrauterine device of the present invention can release copper ions relatively smoothly, eliminating various side effects caused by the burst release of copper ions at the initial stage of traditional copper-containing IUD implantation; during long-term use, the surface of the material is relatively smooth and clean , There is no obvious corrosion product accumulation and corrosion product shedding phenomenon, and it has a good contraceptive effect.

Description

technical field [0001] The present invention relates to an intrauterine contraceptive device for women, in particular to a Cu-Zn composite intrauterine contraceptive device and a preparation method thereof. Background technique [0002] The intrauterine device (IUD) is a contraceptive device that is implanted in the uterus, acts locally, and has less interference with body functions. contraceptive device. Nearly 141 million women of childbearing age in my country use IUDs for contraception, but the traditional copper-containing IUDs have the phenomenon of bursting copper ions in the early stage of implantation in the human uterus, and excessive copper ions will aggravate endometrial tissue damage and inflammation. The user may experience side effects such as abdominal discomfort or even pain and increased menstrual blood. The patent (2020105650069) discloses an ultra-fine-grained Cu-Mg alloy intrauterine device, which uses an ultra-fine-grained Cu-Mg alloy as a copper ion s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14A61L31/16A61F6/14
CPCA61L31/124A61L31/16A61L31/14A61F6/14A61L2300/102A61L2300/408A61L2300/602A61L2300/41A61L2300/412
Inventor 饶永
Owner 吴江永元生物科技有限公司
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