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A kind of pharmaceutical composition for treating hemorrhoids and preparation method thereof

A composition and drug technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve problems such as complex components, and achieve the effects of fewer prescriptions, easy industrial production, and good curative effect.

Active Publication Date: 2022-05-17
廊坊名草堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of the Dai medicine plaster for hemorrhoids is too complicated, and antagonism is often produced between the components

Method used

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  • A kind of pharmaceutical composition for treating hemorrhoids and preparation method thereof
  • A kind of pharmaceutical composition for treating hemorrhoids and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The pharmaceutical composition for treating hemorrhoids comprises the following components in parts by weight: 50 parts of Sophora japonica extract, 50 parts of Aesculus aescini flower extract, 10 parts of mother of pearl, 5 parts of matrine and 500 parts of stearic acid.

[0025] The method for extracting the Sophora japonica extract is as follows: take 2-year-old Sophora japonica bark, mash it into a slurry, add 6 times the weight of water to decoct for 3 hours, filter the medicinal liquid, add 3 times the weight of water to decoct the medicinal residue Boil for 2 hours, filter the medicinal liquid, discard the medicinal residues; combine the two medicinal liquids, evaporate to dryness, and make it.

[0026] The extraction method of the Aesculus aesculus extract is: take the 5-year-old Aesculus Aesculus tuber, mash it into a slurry, add 5 times the weight of water to decoct for 3 hours, filter the medicinal liquid, and add 4 Double the weight of water and decoct for 2...

Embodiment 2

[0031] The pharmaceutical composition for treating hemorrhoids comprises the following components in parts by weight: 70 parts of Sophora japonica extract, 70 parts of Aesculus aescini flower extract, 6 parts of mother of pearl, 4 parts of matrine, and 400 parts of babu ointment.

[0032] The method for extracting the Sophora japonica extract is as follows: take 3-year-old Sophora japonica bark, smash it into a slurry, add 8 times the weight of water to decoct for 4 hours, filter the medicinal liquid, add 4 times the weight of water to decoct the medicinal residue Boil for 3 hours, filter the medicinal liquid, discard the medicinal residues; combine the two medicinal liquids, evaporate to dryness, and make it.

[0033] The extraction method of the Aescinus aesculus extract is as follows: take the tuber of the 4-year-old Aesculus Aesculus, mash it into a slurry, add 6 times the weight of water to decoct for 4 hours, filter the medicinal liquid, add 5 Double the weight of water ...

experiment example

[0057] (1) Rat Modeling

[0058] SPF grade SD rats were taken, and after feeding for 3 days, 12 were randomly selected as the blank group. The other SD rats were first disinfected with perianal skin, and 0.05 mL of 75% acetic acid solution was injected subcutaneously around the anus of the rats. Observed after 24 hours, white ulcers can be seen The face and perianal swelling and inflammatory exudation indicated that the modeling was successful. The successful modeling rats were randomly divided into 7 groups: the model group, the Mayinglong Shexiang hemorrhoid ointment group (8g·kg -1 ), embodiment 1-2 and comparative example 1-3 group (8g·kg -1 ). The blank group and the model group were smeared perianal saline, divided into 3 times, 10min / time; the Mayinglong Musk Hemorrhoid Ointment group was smeared with Mayinglong Musk Hemorrhoid Ointment, divided into 3 times, 10min / time; Ratio Groups 1-3 smear their respective prepared pharmaceutical compositions on the perianal area,...

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Abstract

The invention discloses a pharmaceutical composition for treating hemorrhoids and a preparation method thereof. The active ingredients of the pharmaceutical composition include: Sophora japonica extract, Aesculus aescini extract, mother of pearl and matrine. The pharmaceutical composition for treating hemorrhoids of the present invention adopts the extract essence of Aescin and Sophora japonica as the main components of the medicinal effect, and the combined use of the two has a synergistic effect, and the traditional Chinese medicine for extracting flowers and fruits is not used for the Sophora japonica extract. The method of active ingredients has achieved good curative effect. Mother-of-pearl and matrine have the effect of disinfecting and assisting in increasing the curative effect. The formula of the invention uses few prescriptions, has remarkable curative effect and is easy for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medicinal composition for treating hemorrhoids and a preparation method thereof. Background technique [0002] Hemorrhoids are chronic diseases in which the venous plexus at the bottom of the anorectum varicose to form a venous mass, including internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids. It is the most common anorectal disease clinically. The traditional Chinese medical treatment of hemorrhoid comprises oral administration and external application, and external application is because of directly acting on diseased part, and onset is quick, and effect is good, therefore be paid close attention to and pay attention to by people day by day. [0003] Existing external Chinese medicines for treating hemorrhoids, except Antai Suppository and Mayinglong Shexiang Hemorrhoid Ointment, have complex components and poor therapeutic ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K9/06A61P9/14A61K35/618A61K31/4375
CPCA61K36/489A61K36/896A61K35/618A61K31/4375A61K9/06A61K9/0031A61P9/14A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 张艳兵
Owner 廊坊名草堂生物科技有限公司
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