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Cellular factor conjoint analysis as schizophrenia marker and application thereof

A technology for schizophrenia and cytokines, which is applied in the field of detecting the effect of medication on patients with schizophrenia, can solve the problems of difficulty in determining the detection effect, undisclosed detection of AUC value, specificity and sensitivity, etc., and achieve rigorous and high sensitivity in diagnosis sex and specificity effects

Active Publication Date: 2021-07-23
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] CN101454669B discloses that more than 3 kinds of cytokines are combined to detect the mental state, but it does not disclose the AUC value, specificity and sensitivity of the detection, and the specific detection effect is difficult to determine

Method used

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  • Cellular factor conjoint analysis as schizophrenia marker and application thereof
  • Cellular factor conjoint analysis as schizophrenia marker and application thereof
  • Cellular factor conjoint analysis as schizophrenia marker and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The subjects were 24 first-episode schizophrenic patients (FEDF) admitted to Foshan Third People's Hospital, and 25 age- and gender-matched healthy volunteers were recruited as controls (HC). Among them, 19 schizophrenic patients received eight-week Peripheral blood samples were collected again after the short-term treatment. All physicians involved in the diagnosis work have the qualifications of psychiatrists and have more than 10 years of experience in psychiatry. They are proficient in ICD-10 and DSM-V diagnostic criteria, and use the Positive and Negative Schizophrenia Scale (PANSS) to evaluate patients. The psychopathological state of the patients was evaluated, the operation was standardized, and the consistency test met the requirements (Kappa=0.68-0.82). Schizophrenia patients with comorbidities were excluded before enrollment. All participants gave written informed consent before inclusion in the study. The study protocol was approved by the Ethics Committee ...

Embodiment 2

[0056] On the basis of Example 1, the diagnostic effects of the six factors of G-CSF, IFN-γ, IL-2, IL-4, MIG, and EGF were observed separately, and represented by the ROC curve. The larger the area under the line (AUC) of the ROC curve, the better the diagnostic effect.

[0057] The result is as image 3 It showed that the AUCs of G-CSF, IFN-γ, IL-2, IL-4, MIG and EGF were 0.945, 0.942, 0.774, 0.750, 0.867 and 0.718, respectively. Among them, G-CSF and IFN-γ had the best diagnostic effects, and the sensitivity and specificity of the two factors reached 95.8% and 80.0%.

[0058] Furthermore, the diagnostic effect of the combination of G-CSF, IL-2, IL-4, MIG and EGF was expressed by ROC curve. The larger the area under the line (AUC) of the ROC curve, the better the diagnostic effect.

[0059] The result is as Figure 4 It was shown that the AUC of the combined analysis of G-CSF, IL-2, IL-4, MIG and EGF five factors was 0.993, and its sensitivity and specificity reached 100%...

Embodiment 3

[0061] The diagnostic effect of the combination of G-CSF, IL-2, IL-4, IFN-γ, MIG and EGF is expressed by ROC curve. The larger the area under the line (AUC) of the ROC curve, the better the diagnostic effect.

[0062] The result is as Figure 5 As shown, the AUC of the joint analysis of G-CSF, IFN-γ, IL-2, IL-4, MIG and EGF six factors was 0.997. Its sensitivity and specificity reached 100% and 96%.

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Abstract

The invention provides cell factor conjoint analysis as a schizophrenia marker and application of the schizophrenia marker, and particularly provides application of a reagent material and / or instrument equipment for detecting the level of cell factors in a sample from a to-be-detected individual in preparation of a kit for diagnosing schizophrenia. The cell factors comprise G-CSF, IL-2, IL-4, MIG and EGF. When the cell factors are used for conjoint analysis, high sensitivity and high specificity are achieved while the AUC value is high, and a large application prospect is achieved.

Description

technical field [0001] The present invention relates to a biomarker for diagnosing schizophrenia patients and related applications, in particular, it relates to the use of combined analysis of cytokines as a technique for diagnosing suspected patients with schizophrenia or detecting the effect of medication on patients with schizophrenia , belonging to the field of biology and medical technology. Background technique [0002] Schizophrenia (SCZ), one of the most common mental disorders in the world, is a group of severe mental illnesses of unknown etiology, mostly in young adults with slow or subacute onset, and clinical manifestations are often different Syndrome involving many aspects of perception, thinking, emotion and behavior, as well as incoordination of mental activities. Thought disorder is the core symptom of schizophrenia, and delusions are the most common and important thought content disorder. It is estimated that up to 80% of patients with schizophrenia have ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883G01N33/6893G01N33/6866G01N33/6869G01N33/6863G01N33/6872G01N2800/302G01N2333/535G01N2333/5406G01N2333/55G01N2333/522G01N2333/485G01N2333/475G01N2333/523G01N2333/525G01N2333/57C12Q2600/158C12Q2600/106
Inventor 程勇杜洋陈磊
Owner MINZU UNIVERSITY OF CHINA
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