Combined analysis of cytokines as a marker of schizophrenia and its application

A technology for schizophrenia and cytokines, which is applied in the field of detecting the effects of medication in patients with schizophrenia, can solve the problems that the detection effect is difficult to determine, the AUC value, specificity and sensitivity of the detection are not published publicly, and the diagnosis is rigorous and highly sensitive. Sexual and specific effects

Active Publication Date: 2022-07-01
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] CN101454669B discloses that more than 3 kinds of cytokines are combined to detect the mental state, but it does not disclose the AUC value, specificity and sensitivity of the detection, and the specific detection effect is difficult to determine

Method used

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  • Combined analysis of cytokines as a marker of schizophrenia and its application
  • Combined analysis of cytokines as a marker of schizophrenia and its application
  • Combined analysis of cytokines as a marker of schizophrenia and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The subjects were 24 first-episode schizophrenia patients (FEDF) admitted to the Third People's Hospital of Foshan City, and 25 age- and sex-matched healthy volunteers were recruited as controls (HC), of which 19 patients with schizophrenia received eight-week treatment. Peripheral blood samples were collected again after short-term treatment. All physicians involved in the diagnosis work are qualified as psychiatrists and have more than 10 years of experience in psychiatry. They are proficient in ICD-10 and DSM-V diagnostic criteria. The psychopathological state of the patients was evaluated, the operating standards were unified, and the consistency test met the requirements (Kappa=0.68-0.82), and schizophrenia patients with comorbidities were excluded before enrollment. All participants gave written informed consent before inclusion in the study. The study protocol was approved by the Ethics Committee of the Third People's Hospital of Foshan.

[0041] 1. Serum Extra...

Embodiment 2

[0056] On the basis of Example 1, the diagnostic effects of G-CSF, IFN-γ, IL-2, IL-4, MIG, and EGF were independently observed and represented by ROC curve. The larger the area under the line (AUC) of the ROC curve, the better the diagnostic effect.

[0057] The result is as image 3 It was shown that the AUCs of G-CSF, IFN-γ, IL-2, IL-4, MIG, and EGF were 0.945, 0.942, 0.774, 0.750, 0.867 and 0.718, respectively. Among them, G-CSF and IFN-γ had the best diagnostic effect, and the sensitivity and specificity of the two factors reached 95.8% and 80.0%.

[0058] Further, the diagnostic effect of the combination of five factors of G-CSF, IL-2, IL-4, MIG and EGF was observed and represented by ROC curve. The larger the area under the line (AUC) of the ROC curve, the better the diagnostic effect.

[0059] The result is as Figure 4 It was shown that the AUC of the combined analysis of G-CSF, IL-2, IL-4, MIG and EGF was 0.993, and its sensitivity and specificity reached 100% and...

Embodiment 3

[0061] The diagnostic effect of G-CSF, IL-2, IL-4, IFN-γ, MIG and EGF combination of six factors was observed and represented by ROC curve. The larger the area under the line (AUC) of the ROC curve, the better the diagnostic effect.

[0062] The result is as Figure 5 As shown, the AUC of the combined analysis of the six factors G-CSF, IFN-γ, IL-2, IL-4, MIG and EGF was 0.997. Its sensitivity and specificity reached 100% and 96%.

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Abstract

The present invention provides a combined analysis of cytokines as a marker for schizophrenia and its application. Specifically, the present invention provides reagents, materials and / or instruments and equipment for detecting cytokine levels in samples from individuals to be tested. The application in the kit for schizophrenia, wherein the cytokines include: G-CSF, IL-2, IL-4, MIG and EGF. Using the cytokine of the present invention for combined analysis has high AUC value, high sensitivity and high specificity, and has a great application prospect.

Description

technical field [0001] The present invention relates to a biomarker for diagnosing schizophrenia patients and related applications, in particular, to a technology for diagnosing suspected schizophrenia patients or detecting the effect of schizophrenia patients after using the combined analysis of cytokines , belonging to the field of biology and medical technology. Background technique [0002] Schizophrenia (SCZ) is one of the most common mental disorders in the world. It is a group of severe mental illnesses of unknown etiology. Most of the onset is slow or subacute in young adults, and clinical symptoms are often different. Syndrome involving sensory, thinking, emotional and behavioral disorders, as well as incoordination of mental activities. Thought disorder is the core symptom of schizophrenia, and delusions are the most common and important thought content disorder. It is estimated that up to 80% of patients with schizophrenia have persecutory delusions. In severe c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883G01N33/6893G01N33/6866G01N33/6869G01N33/6863G01N33/6872G01N2800/302G01N2333/535G01N2333/5406G01N2333/55G01N2333/522G01N2333/485G01N2333/475G01N2333/523G01N2333/525G01N2333/57C12Q2600/158C12Q2600/106
Inventor 程勇杜洋陈磊
Owner MINZU UNIVERSITY OF CHINA
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