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Application of dexmedetomidine in preparation of pharmaceutical composition for improving diabetic peripheral neuropathy

A technology for peripheral neuropathy and dexmedetomidine, which is applied in the field of application of dexmedetomidine in the preparation of pharmaceutical compositions for improving diabetic peripheral neuropathy, which can solve problems such as ambiguity and achieve the effect of expanding the scope of application

Pending Publication Date: 2021-08-10
LIUZHOU WORKERS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the specific mechanism of how Bax, caspase-3 and Bcl-2 are regulated in DPN is still unclear.

Method used

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  • Application of dexmedetomidine in preparation of pharmaceutical composition for improving diabetic peripheral neuropathy
  • Application of dexmedetomidine in preparation of pharmaceutical composition for improving diabetic peripheral neuropathy
  • Application of dexmedetomidine in preparation of pharmaceutical composition for improving diabetic peripheral neuropathy

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Embodiment

[0038] Application of dexmedetomidine in preparation of improving diabetic peripheral neuropathy pharmaceutical composition:

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Abstract

The invention discloses an application of dexmedetomidine in preparation of a pharmaceutical composition for improving diabetic peripheral neuropathy, a rat type II diabetes model and a rat RSC96 cell line are prepared through a high-fat and high-glucose combined small-dose intraperitoneal injection streptozotocin (STZ) method, a DPN model is established in vitro, DEX, DEX and an alpha2 receptor blocker yohimbine are applied, the effects of DEX and a transfected miR-34a reinforcing agent mimics, DEX and a transfected miR-34a inhibitor antitagomir, DEX and a transfected SIRT1 overexpression plasmid, and DEX and a transfected SIRT1 silent plasmid on rats and cell lines are provided, the influence of DEX on DPN is judged by detecting cell apoptosis, and the regulation mechanism of improving diabetic rat peripheral neuropathy by regulating miR-34a in a targeting manner to regulate SIRT1 is discussed for the first time.

Description

【Technical field】 [0001] The invention relates to the technical field of drugs for treating diabetes, and relates to the application of dexmedetomidine in preparing a pharmaceutical composition for improving diabetic peripheral neuropathy. 【Background technique】 [0002] Diabetes mellitus is a chronic metabolic disease that seriously threatens human health. It has become the third largest chronic non-communicable disease in developed countries after cerebrovascular disease and tumor. Long-term hyperglycemia is generally toxic to the internal environment of the body and can cause pathological reactions in peripheral nerves. Diabetic patients generally have macrovascular and microvascular lesions, among which Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes. With the improvement of diabetes treatment methods and clinical efficacy, the life expectancy of diabetic patients has increased significantly. With the prolongation of the course of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61P3/10A61P25/02
CPCA61K31/4174A61P3/10A61P25/02
Inventor 张延卓韦钰叶茂英覃媛媛唐斌李春妮
Owner LIUZHOU WORKERS HOSPITAL
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