Traditional Chinese medicine hair care liquid formula for enhancing tyrosinase activity
A technology of tyrosinase and hair conditioner, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, hair care, etc.
Active Publication Date: 2021-08-31
福州膳柏健康产业有限公司
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Problems solved by technology
[0006] There have been reports in the literature on the determination of tyrosinase activity by a single high-concentration alcoholic extract (such as 90% ethanol concentration) of the above-mentioned three medicinal materials. Obtain low-concentration ethanol solution, add transdermal penetration enhancer peppermint oil, constitute the fat-soluble component low-concentration ethanol hair conditioner of the three-flavor medicinal material compound, have not yet been reported
Method used
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Effect test
Embodiment 1
[0049] Polygonum multiflorum 90g Ligustrum lucidum 90g Ginseng 9g 20% ethanol 0.3% peppermint oil
[0050] Weigh the prescription amount of Radix Polygoni Multiflori, Ligustrum lucidum and Ginseng, mix well, use 5 times of 90% ethanol to reflux extract twice, each time for 45 minutes, filter, combine the filtrate, concentrate until the ethanol concentration is 20% solution, add 0.3% Peppermint oil, mixed evenly, packaged, is a solution-type head care solution.
Embodiment 2
[0052] Polygonum multiflorum 90g Ligustrum lucidum 120g Ginseng 12g 10% ethanol 0.4% peppermint oil AES amount
[0053] Weigh Polygonum Polygoni Multiflori, Ligustrum lucidum and Ginseng, mix them evenly, and extract twice with 82% ethanol under reflux for 1.5 hours each time, filter, combine the filtrates, concentrate until the ethanol concentration is 15% solution, add 0.4 % of peppermint oil and an appropriate amount of emulsifier AES, mixed evenly, and packaged, it is a foam-type head care solution.
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The invention relates to a traditional Chinese medicine hair care liquid formula for enhancing tyrosinase activity, in particular to the traditional Chinese medicine hair care liquid formula for enhancing tyrosinase activity, which is prepared by extracting a compound of three medicinal materials of polygonum multiflorum, glossy privet fruit and ginseng by using high-concentration ethanol, obtaining a high-concentration ethanol solution of low-viscosity and high-permeability fat-soluble components, recovering ethanol to obtain a low-concentration ethanol solution, adding a transdermal penetration enhancer peppermint oil, and forming the traditional Chinese medicine hair care liquid formula. According to the prepared traditional Chinese medicine hair care liquid formula, the activation capacity of tyrosinase is obviously enhanced, the activation capacity of tyrosinase in the formula of 80% alcohol extraction reaches 198%, the activation capacity is obviously higher than that of tyrosinase in the formula of non-three medicinal material compounds, and the effective improvement of the hair blacking function is promoted. The traditional Chinese medicine hair care liquid formula is applied to development of hair care liquid for the head, permeation promotion of the extracts is rapidly improved, and an effective way is provided for the problems that an existing traditional Chinese medicine oral hair-blacking preparation is large in liver first-pass effect, low in bioavailability, small in scalp medicine accumulation concentration and low in cost, and the tyrosinase activation capability of a water-soluble extract in an external preparation is weak and the like.
Description
technical field [0001] The patent of the invention belongs to the field of transdermal system of pharmaceutical preparations, and specifically relates to a formula of traditional Chinese medicine hair conditioner that enhances the activity of tyrosinase. Background technique [0002] The traditional Chinese medicine compound recipe of the invention is composed of Polygonum multiflorum multiflorum, Ligustrum lucidum and Ginseng three kinds of medicinal materials, and has the effects of nourishing liver and kidney, black hair and hair care. [0003] Polygonum multiflorum is the dry root tuber of Polygonum multiflorum Polygonum multiflorum. It tastes bitter, sweet, astringent, warm in nature, and returns to the liver, heart and kidney meridians. "Compendium of Materia Medica" claims that it can "nourish blood and nourish liver, strengthen essence and kidney, strengthen muscles and bones, and black mustache hair". Anthraquinone lipid-soluble active ingredients such as emodin me...
Claims
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IPC IPC(8): A61K8/9789A61K8/92A61Q5/12
CPCA61K8/9789A61K8/922A61Q5/12A61K2800/78A61K2800/805
Inventor 李孝栋曾建伟何怡静
Owner 福州膳柏健康产业有限公司