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Experimental method for researching and treating premature ovarian failure based on placenta-derived mesenchymal stem cells

A technology of mesenchymal stem cells and premature ovarian failure, applied in the field of biological stem cells, can solve problems such as unsustainable and unresolved autoimmune problems, and achieve the effect of optimizing the use method, good treatment method, and optimizing the process flow

Pending Publication Date: 2021-10-19
江苏育瑞康生物科技有限公司
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  • Abstract
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Problems solved by technology

However, if the autoimmune problem is not resolved, the imported cells will be quickly eliminated, and the continuous immune damage will offset the repairing effect of stem cells. Even if the effect is short-term, it will not be sustainable

Method used

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Examples

Experimental program
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Embodiment Construction

[0019] In order to better understand the technical content of the present invention, specific examples are given as follows. Embodiments of the present disclosure are not necessarily intended to include all aspects of the invention. It should be understood that the concepts and embodiments disclosed herein are not limited to any implementation. In addition, some aspects of the present disclosure may be used alone or in any suitable combination with other aspects of the present disclosure.

[0020] This example provides an experimental method for the treatment of premature ovarian failure based on placenta-derived mesenchymal stem cells, which can facilitate researchers to find and verify the cell source / preparation with the strongest immune negative regulation / repair function, and study its mechanism of action. Examples are as follows:

[0021] Extraction and separation of placental mesenchymal stem cells (PMSC): take a freshly delivered sterile and non-calcified placenta, c...

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Abstract

The invention provides an experimental method for researching and treating premature ovarian failure based on placenta-derived mesenchymal stem cells. The method comprises the following steps: S1, extraction and separation of mesenchymal stem cells: the mesenchymal stem cells are placenta mesenchymal stem cells or umbilical cord mesenchymal stem cells, and passage is carried out after extraction and separation of the mesenchymal stem cells. From the perspective of avoiding autoimmune persistent injury of immune POF patients, through comparison of expressions of mesenchymal stem cells with different sources, different phenotypes, different proportions and different generations on immune related gene loci, an in-vitro immunosuppression experiment and differentiated research of effects of an in-vivo unified autoimmune POF mouse animal model, the immune POF mouse model is subjected to in-vitro immunosuppression experiments, and the cell source / preparation with the strongest immune negative regulation / repair function is searched and verified; and the possible action mechanism of the traditional Chinese medicine composition is researched, the optimal dosage form for immune premature ovarian failure is determined, then the process flow, the use method and the like are convenient to optimize, and a better premature ovarian failure treatment method is found.

Description

technical field [0001] The invention relates to the technical field of biological stem cells, in particular to an experimental method for researching and treating premature ovarian failure based on placenta-derived mesenchymal stem cells. Background technique [0002] The ovary is one of the female reproductive and endocrine organs, and the normal function of the ovary is an important guarantee to ensure the quality of life of women. Premature ovarian failure (POF) refers to ovarian failure in women before the age of 40 due to depletion of ovarian follicles or iatrogenic injury. POF is a common disease in the field of gynecological endocrinology, and its incidence rate is about 1% to 3%. The incidence rate of women before the age of 40 is 1%, and the incidence rate of women before the age of 30 is 0.1%. In recent years, the incidence of POF has increased year by year, and the proportion of POF in female infertility patients has also increased year by year. The two main thr...

Claims

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Application Information

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IPC IPC(8): G01N33/76G01N33/74G01N33/68G01N15/14C12Q1/6851
CPCG01N33/743G01N33/76G01N33/6866G01N33/6863G01N33/74G01N15/14C12Q1/6851C12Q2531/113C12Q2563/107
Inventor 王建波刘韬翁平
Owner 江苏育瑞康生物科技有限公司
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