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Hemostatic sponge cushion core and preparation method thereof

The technology of hemostatic sponge and pad core is applied in the field of hemostatic sponge pad core and its preparation, which can solve the problems of poor mechanical properties and unsatisfactory hemostatic effect, and achieve the effect of facilitating mechanical production.

Active Publication Date: 2021-11-19
桂林福康森医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the current existing hemostatic sponges, which are generally made of collagen or chitosan hemostatic materials, resulting in poor mechanical properties, unsatisfactory hemostatic effects, and inability to meet the requirements of clinical operations, the present invention provides a hemostatic sponge pad core and its The preparation method is to apply the hemostatic sponge on the absorbent pad in the foam stage, and it will not disappear after drying. It can be further prepared into a functional dressing with adhesive tape, which is suitable for hemostasis and wound protection after dialysis and surgery on the human body surface.

Method used

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  • Hemostatic sponge cushion core and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation method of hemostatic sponge pad core, comprises the steps:

[0029] 1) Prepare raw materials according to the ratio: 10g gelatin, 90g distilled water, 3ml 0.25% glutaraldehyde solution, 2.5ml 0.5% formaldehyde;

[0030] 2) Pour the gelatin into distilled water, soak for 10 minutes, heat in a water bath at 65°C, stir to dissolve, add 0.5% (v / v) formaldehyde, and stir at a high speed (400rpm, 20min) to obtain a foamy liquid mixed solution;

[0031] 3) Pour the mixed solution obtained in the above step into molds of different specifications. The bottom of the mold is covered with a water-absorbing pad core, which is pre-frozen at -40 to -80°C and then freeze-dried to obtain a water-absorbing pad core with a sponge;

[0032] 4) Cross-link the absorbent pad core with sponge obtained in the above step with 0.25% (v / v) glutaraldehyde solution. After the cross-linking is completed, wash it with distilled water for several times and freeze-dry it again. Adhesive...

Embodiment 2

[0034] The preparation method of hemostatic sponge pad core, comprises the steps:

[0035] 1) Prepare raw materials according to the ratio: gelatin 9.5g, distilled water 92mL, 0.25% (v / v) glutaraldehyde solution 2.8mL, 0.5% (v / v) formaldehyde 2.6mL;

[0036] 2) Pour the gelatin into distilled water, soak for 10 minutes, heat in a water bath at 60°C, stir to dissolve, add 0.5% (v / v) formaldehyde, and stir at a high speed (300rpm, 25min) to obtain a foamy liquid mixed solution;

[0037] 3) Pour the mixed solution obtained in the above step into molds of different specifications. The bottom of the mold is covered with a water-absorbing pad core, which is pre-frozen at -40 to -80°C and then freeze-dried to obtain a water-absorbing pad core with a sponge;

[0038]4) Cross-link the absorbent cushion core with sponge obtained in the above step with 0.25% (v / v) glutaraldehyde solution. After the cross-linking is completed, wash it with distilled water several times and freeze-dry it a...

Embodiment 3

[0040] The preparation method of hemostatic sponge pad core, comprises the steps:

[0041] 1) Prepare raw materials according to the ratio: 10.5g gelatin, 88mL distilled water, 3.2mL 0.25% (v / v) glutaraldehyde solution, 2.4mL 0.5% (v / v) formaldehyde;

[0042] 2) Pour the gelatin into distilled water, soak for 10 minutes, heat in a water bath at 70°C, stir to dissolve, add 0.5% (v / v) formaldehyde, and stir at a high speed (200rpm, 30min) to obtain a foamy liquid mixed solution;

[0043] 3) Pour the mixed solution obtained in the above step into molds of different specifications. The bottom of the mold is covered with a water-absorbing pad core, which is pre-frozen at -40 to -80°C and then freeze-dried to obtain a water-absorbing pad core with a sponge;

[0044] 4) Cross-link the absorbent cushion core with sponge obtained in the above step with 0.25% (v / v) glutaraldehyde solution. After the cross-linking is completed, wash it with distilled water several times and freeze-dry it...

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Abstract

According to the hemostatic sponge cushion core and the preparation method thereof, a hemostatic sponge is smeared on a water absorption cushion in the foaming stage and does not disappear after being dried, and the hemostatic sponge cushion core can be further prepared into a functional dressing with an adhesive tape and is suitable for hemostasis and wound protection after human body surface dialysis and operation.

Description

【Technical field】 [0001] The invention relates to the technical field of polymer medical materials, in particular to a hemostatic sponge pad core and a preparation method thereof. 【Background technique】 [0002] The hemostatic sponge is used for rapid hemostasis, antibacterial and anti-infection, can absorb a large amount of blood and tissue exudate, and accelerate wound healing. The normal hemostasis of the body mainly depends on the complete structure and function of the blood vessel wall, the quality and quantity of effective platelets, and the normal activity of coagulation factors, among which the role of negatively charged platelets and coagulation factors is the main one. The hemostatic sponge uses its fine, porous, and positively charged hemostatic material. When it comes into contact with human blood, it can immediately adhere to and aggregate platelets, so that the blood can form a thrombus, block the wound, and release various substances related to blood coagulati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/00A61L15/32A61L15/42
CPCA61L24/104A61L24/0036A61L15/32A61L15/425A61L2400/04
Inventor 王纯斌王纯保肖亚兰
Owner 桂林福康森医疗器械有限公司
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