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Application of lactic acid and salt thereof

A technology of lactic acid and sodium lactate, applied in the field of medicine, can solve problems such as unreported lactic acid, and achieve the effect of reducing local inflammatory reaction and reducing severity.

Pending Publication Date: 2022-01-07
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some scholars have found that lactic acid can reduce intestinal inflammation through the GPR81 signaling pathway in both in vitro and in vivo disease models, but whether lactic acid has a similar effect on GMI has not yet been reported

Method used

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  • Application of lactic acid and salt thereof
  • Application of lactic acid and salt thereof
  • Application of lactic acid and salt thereof

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Embodiment Construction

[0018] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0019] The application of lactic acid and its salts. The lactic acid and its salts are used in the preparation of drugs for preventing or treating ethanol-induced gastric mucosal injury, and the salts are pharmaceutically acceptable salts.

[0020] In an embodiment, the salt is sodium lactate.

[0021] In an embodiment, the drug also includes other drugs compatible with the lactic acid or a pharmaceutically acceptable salt thereof, as well as pharmaceutically acceptable carriers and / or excipients.

[0022] In an embodiment, the drug is in a pharmaceutically acceptable dosage form.

[0023] In an embodiment, the dosage form is powder, injection, capsule, tablet or oral liquid.

[0024] The following experiments illustrate that lactic acid and its salts can alleviate gastric mucosal damage induced by ethanol.

[0025] We used ethanol-induced ...

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Abstract

The invention discloses application of lactic acid and salt thereof. The lactic acid and the salt thereof are applied to preparation of drugs for preventing or treating ethanol-induced gastric mucosal lesion, and the salt is pharmaceutically acceptable salt. The lactic acid can reduce uncontrolled local inflammatory response when gastric mucosa is damaged, and intervene in apoptosis of gastric mucosa cells by down-regulating expression of Bax and Caspase-3 genes; and in addition, the lactic acid can up-regulate the expression of tight junction protein genes such as Occludin, Claudin-1 and Claudin-5 in gastric tissues, and finally, the severity of the ethanol-induced gastric mucosal lesion is remarkably relieved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of lactic acid and its salts. Background technique [0002] Gastric mucosal injury (GMI) is a common precancerous condition that is associated with a high incidence of gastric cancer in many Asian countries, including China. GMI is considered to be a disease mainly caused by strong local inflammatory response of gastric mucosa. It has been confirmed that the overexpression of inflammatory cytokines such as IL-1β, TNF-α and IL-6 are all involved in the injury process of GMI. In addition, apoptosis is another key mechanism leading to gastric mucosal damage. Bax, a cytoplasmic protein permeable to the outer mitochondrial membrane, is one of the core regulators of the intrinsic apoptotic pathway. Caspase-3 is the key executive protein of caspase cascade reaction of apoptosis, it can interact with Caspase-8 and Caspase-9. Previous studies have confirmed the up-regu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P1/04
CPCA61K31/19A61P1/04
Inventor 王方岩黄颖鹏周锦慧陈佳静周燕白植淮季夏薇
Owner WENZHOU MEDICAL UNIV
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