LincR-0003 and application thereof as molecular marker for early diagnosis of radiation damage
A molecular marker, radiation damage technology, applied in the determination/inspection of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve problems such as unreported
Pending Publication Date: 2022-03-22
CHINA INST FOR RADIATION PROTECTION
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Problems solved by technology
[0005] LincR-0003 is located on human chromosome 5 and is involved in the development of the prefrontal cortex, but the correlation between LincR-0003 and exposure to ionizing radiation has not been reported at home and abroad
Method used
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Embodiment 1
[0014] 1. Preliminary screening of radiation-sensitive molecular markers using lincRNA chip technology
[0015] 1) Extraction, quantification and quality inspection of total cellular RNA
[0016] Human peripheral venous blood was irradiated with 0.2Gy γ-rays (a non-irradiated control group was set at the same time), and 6 hours after irradiation, RNA was extracted with a peripheral blood RNA extraction kit (Tiangen Biochemical Technology Co., Ltd.), and the RNA samples were quality-tested by Nanodrop Quantitative (OD260 / 280: 1.80-1.88, total amount: 2181.80-3558.80ng).
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The invention belongs to the technical field of biological detection, and relates to LincR-0003 and application thereof as a molecular marker for early diagnosis of radiation damage. By using the LincR-0003 as the molecular marker for early diagnosis of radiation damage, radiation exposure diagnosis can be conveniently, accurately and quantitatively carried out.
Description
technical field [0001] The invention belongs to the technical field of biological detection, and relates to LincR-0003 and its use as a molecular marker for early diagnosis of radiation damage. Background technique [0002] At present, the health monitoring of radiation workers mainly includes physical examination, health risk assessment and disease prevention and treatment. Daily health checkups mainly use routine clinical examinations, and special health checkups include chromosomal aberrations and micronucleus analysis. However, the indicators they involve cannot effectively detect the occurrence of radiation-induced diseases at an early stage. [0003] Molecular indicators obtained by molecular biology-related technologies can supplement and improve physical examination methods to achieve early diagnosis and early treatment of diseases. Therefore, in order to improve the existing health monitoring system and avoid or reduce the potential risks of radiation hazards, it ...
Claims
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Patent Timeline
Login to View More IPC IPC(8): C12N15/113C12Q1/6883
CPCC12N15/113C12Q1/6883C12Q2600/178C12Q2600/158
Inventor 董娟聪原雅艺杨彪党旭红程娇孟倩倩王超张忠新柴栋良任越左雅慧
Owner CHINA INST FOR RADIATION PROTECTION