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Hsa-miR-23c and application thereof as molecular marker for early diagnosis of radiation damage

A technology of hsa-mir-23c and molecular markers, which is applied in the determination/inspection of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve problems that have not been reported, and achieve the effect of quantitative radiation exposure diagnosis

Pending Publication Date: 2022-03-22
CHINA INST FOR RADIATION PROTECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] hsa-miR-23c is related to tumor proliferation, apoptosis, migration, invasion, etc., and its function in tumor diagnosis and prognosis plays an important role in the diagnosis and prognosis of liver cancer, glioma and non-small cell lung cancer. Partially reported, but the correlation between hsa-miR-23c and exposure to ionizing radiation has not been reported at home and abroad

Method used

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  • Hsa-miR-23c and application thereof as molecular marker for early diagnosis of radiation damage
  • Hsa-miR-23c and application thereof as molecular marker for early diagnosis of radiation damage

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Use high-throughput sequencing technology to preliminate radiation-sensitive molecular markers

[0015] 1) Extraction, quantitative and quality inspection of total miRNA

[0016] The peripheral venous blood was irradiated with 0.2 Gy gamma ray (at the same time as a non-irradiated control group), 6 h after irradiation, using peripheral blood miRNA extraction kit (Tiangen Biochemical Technology Co., Ltd.) to extract miRNA, miRNA sample through agarose gel Electrophoresis and NanoDrop perform quality test (OD260 / 280: 1.80-1.89, total: 1699.50-3125.40 ng).

[0017] 2) Construction of the library

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Abstract

The invention belongs to the technical field of biological detection, and relates to hsa-miR-23c and application thereof as a molecular marker for early diagnosis of radiation damage. According to the application of the hsa-miR-23c serving as the molecular marker for early diagnosis of radiation damage, radiation exposure diagnosis can be conveniently, accurately and quantitatively carried out.

Description

Technical field [0001] The invention belongs to the field of biological detection, and the use of HSA-miR-23C and its early diagnosis of radiation injury. Background technique [0002] At present, the health care of radiopters is mainly health checkup, health risk assessment and disease prevention and treatment. Daily health checkups mainly adopt conventional clinical inspections, special health checkups include chromosome distortion and micronuclear analysis. However, the indicators they involve do not effectively avoid the occurrence of the disease caused by radiation. [0003] The molecular indicators obtained by molecular biology related technologies can be supplemented and improved physical examination means, and the disease is early diagnosis, early treatment. Therefore, in order to improve the current health care system, avoid or reduce the potential risks of radiation hazards, and urgently need to establish early health care techniques for radiosalists, thus providing tec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/6883
CPCC12N15/113C12Q1/6883C12N2310/141C12Q2600/178C12Q2600/158
Inventor 董娟聪原雅艺杨彪党旭红孟倩倩程娇王超张忠新左雅慧柴栋良
Owner CHINA INST FOR RADIATION PROTECTION