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Exhaled gas VOC (volatile organic compound) marker and detection system for breast cancer diagnosis or auxiliary diagnosis

An auxiliary diagnosis and marker technology, which can be used in measurement devices, instruments, scientific instruments, etc., can solve the problem of unclear metabolic mechanism of biomarkers, and achieve the effect of high detection sensitivity.

Pending Publication Date: 2022-07-08
LIBEN HEALTHCARE (CHENGDU) CO LTD
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  • Abstract
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Problems solved by technology

[0004] However, due to the fact that the metabolic mechanism of most of the screened biomarkers is not clear, the exhaled breath markers for accurate and effective screening of breast cancer need to be further enriched for clinical practice

Method used

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  • Exhaled gas VOC (volatile organic compound) marker and detection system for breast cancer diagnosis or auxiliary diagnosis
  • Exhaled gas VOC (volatile organic compound) marker and detection system for breast cancer diagnosis or auxiliary diagnosis

Examples

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Embodiment 1

[0027] Example 1. Screening and diagnostic value evaluation of breast cancer biomarkers

[0028] 1) Subjects exhaled alveolar gas collection

[0029] The invention collects the exhaled alveolar gas of breast cancer patients and normal people to screen the diagnostic markers of breast cancer. The breast cancer patient came from a tertiary hospital in southwest China. The patient's physical examination and imaging showed that it was a breast mass, and the postoperative pathological diagnosis was breast cancer. Normal people are people who have no breast lumps in self-examination or physical examination. The experiments were ethically certified and subject to informed consent. The subjects included 29 breast cancer patients, including 21 patients with early breast cancer (I-II stage) and 28 normal people.

[0030] The subjects' breath samples were collected by means of air bags and gas collection cylinders. The present invention collects exhaled breath samples on the day befo...

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Abstract

The invention provides an exhaled gas VOC (volatile organic compound) marker capable of diagnosing or assisting in diagnosing breast cancer and a breast cancer diagnosis or assisting diagnosis detection system based on the VOC marker. The VOC marker is any one or a combination of more of propionaldehyde, n-butyraldehyde, n-valeraldehyde, n-hexanal, n-heptanal, n-octanal, n-nonanal and n-capraldehyde. Detection is carried out based on the VOC marker, high detection sensitivity and specificity are achieved, and a new means is provided for diagnosis and screening of breast cancer.

Description

technical field [0001] The invention belongs to the field of in vitro diagnostic reagents, and particularly relates to an exhaled breath VOC marker and a detection system for breast cancer diagnosis or auxiliary diagnosis. Background technique [0002] Breast cancer is the most common malignant tumor in women, and its morbidity and mortality occupy the first and second place in female malignant tumors, respectively. Early diagnosis and early treatment is an important way to reduce breast cancer mortality and improve its prognosis. At present, the diagnostic methods of breast cancer mainly include mammography, CT scan, ultrasound imaging, magnetic resonance imaging, positron emission tomography and tissue biopsy, etc. However, these methods have low sensitivity and specificity, and relatively low radiation. Large or even sampling trauma and other limitations. Therefore, it is necessary to develop a sensitive, specific, and non-invasive breast cancer screening technology for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/08G01N30/88G01N30/72G01N30/78
CPCG01N30/06G01N30/08G01N30/88G01N30/72G01N30/78
Inventor 杨燕婷李雯雯
Owner LIBEN HEALTHCARE (CHENGDU) CO LTD
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