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Application of glucose-insulin-potassium polarization liquid in preparation of medicine for treating trauma and burn

A technology of insulin and glucose, which is applied in the external application to treat wounds and burns. The known drug mixture, glucose-insulin-potassium polarized liquid, can solve the problems of complex and expensive treatment methods, and achieve inhibition Effects of growth and reproduction, reduction of edema, and increase in energy supply

Inactive Publication Date: 2006-05-10
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, the above-mentioned treatment methods are complicated in technology and expensive, and cannot yet become a routine method for clinical treatment of trauma. Therefore, it is urgent to develop new trauma treatment methods that are simple, cheap, and have no special contraindications.

Method used

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Experimental program
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Embodiment Construction

[0016] The present invention will be further described in detail below in conjunction with the experiments and results provided by the inventors.

[0017] 1. Preparation of medicinal liquid for external application:

[0018] GIK (glucose: 25%-50%, insulin: 25IU / L-50IU / L, KCl: 40mmol / L~100mmol / L, solvent is sterile double distilled water)

[0019] 2. Production of closed external dressing:

[0020] The inner layer is the dressing layer (a piece of sterile gauze soaked in the prepared GIK solution), which is closely attached to the sore surface tissue; the middle layer is the water-proof layer (sterile petroleum jelly gauze); the outer layer is sterile dry gauze, a total of 3 layers , The dressing is closed and fixed with a wide adhesive tape around it.

[0021] 3. Dressing change:

[0022] Ordinary trauma wounds: 1 time / day; 1 time / 2 days after 3 days.

[0023] Burn wound: Dressing (1 time / day), or direct application of exposure therapy as appropriate, 2-3 times / day.

[00...

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Abstract

The invention discloses a medicinal use of a known medicinal mixture-glucose-insulin-potassium (GIK) polarizing solution in external application for treating wounds and burns. The present invention provides the formula dosage of the GIK. It is found in the experiment that the curative effect of high-dose GIK is obviously better than that of low-dose GIK, and it is recommended to use high-dose GIK for external application to treat wounds and burns. Its scope of application is external application to treat traumatic wounds, including burns and refractory ulcers in diabetic patients, etc. It is more effective when used in combination with intravenous infusion in the acute phase of trauma and burns, that is, systemic medication. The invention is simple, easy to implement, cheap, and has no special contraindications, and can be widely and routinely used in large hospitals and small clinics.

Description

technical field [0001] The invention relates to a drug mixture and its application, in particular to a new application of a known drug mixture-glucose-insulin-potassium (GIK) polarization solution in external application for treating wounds and burns. Background technique [0002] In recent decades, the incidence of trauma has been increasing, and the number of deaths and injuries has increased year by year, so it is called "disease of developed society". In my country, trauma has risen to the fourth cause of death after 1995, and the total number of casualties due to trauma is about millions of people every year. From a global perspective, more than 2 million people die and tens of millions of people are injured every year due to trauma. Experts predict that the number of traumatized people in the 21st century may increase exponentially. Therefore, it is one of the problems to be solved urgently in the medical field to explore new technologies for treating trauma so as to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/28A61P17/02
Inventor 高峰张海峰马新亮闫文利
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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