Lipid nano-particle of glyceride behenate and its preparation method

A technology of glyceryl behenic acid and lipid nanoparticles, which is applied in the direction of liposome delivery and powder delivery, can solve the problems of low bioavailability, unstable absorption, and limitation of drug application, so as to improve deficiencies and improve biological Effect of availability and absorption stability

Inactive Publication Date: 2004-05-05
SHANGHAI INST OF PHARMA IND CO LTD
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the field of pharmaceutical preparations, fat-soluble drugs often have disadvantages such as low bioavailability and unstable absorption after administration, which greatly limits the clinical application of such drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lipid nano-particle of glyceride behenate and its preparation method
  • Lipid nano-particle of glyceride behenate and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Take 2.0g ATO and 1.8g soybean lecithin, heat in a water bath at 85°C, dissolve them in 15ml of absolute ethanol, continue heating, evaporate the organic solvent, and then quickly freeze at 0°C for 2 hours, spare;

[0034] (2) Disperse 1.5g of poloxamer188 in 100ml of water at 4°C to form a uniform aqueous phase for later use;

[0035] (3) Mix and grind (mortar, homogenizer) the solid obtained from (1) and the water phase obtained from (2) at 4°C until the particle size is below 100 μm (through a 180-mesh sieve) to form uniform particles water dispersion system;

[0036] (4) the water dispersion of (3) gained is at room temperature, the pressure of 700bar (the Niro Soavi high-pressure homogenizer that adopts GEA company to produce) high-pressure homogenization circulation 5 times (3 minutes), water dispersion is cooled to with ice bath After 10°C, recirculate rapidly 5 times (3 minutes), and rapidly cool to room temperature to prepare 100ml of a water dispersion s...

Embodiment 2

[0039] Prepared by the same method as in Example 1, the amount of ATO added was 1.0 g, soybean lecithin was 2.5 g, and poloxamer188 was 1.5 g.

Embodiment 3

[0041] Prepared by the same method as in Example 1, the amount of ATO added was 3.0 g, soybean lecithin was 0.5 g, and poloxamer188 was 1.5 g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to view more

Abstract

A lipid nanoparticle (size 100-200nm) of glyceride behenate is prepared by the combination of solvent-fusion method and high-pressure emulsifying, where the mixture of ATO and soybean phosphatide is used as carrier and the poloxamer 188 is used as suspending aid to make the medicine is wrapped by lipid nanoparticle to form uniform dispersed system in water. Its advantages are high biological utilization rate and stable absorptivity.

Description

technical field [0001] The invention relates to a drug carrier, in particular to a behenic acid glyceride lipid nanoparticle for fat-soluble drugs and a preparation method thereof. Background technique [0002] In the field of pharmaceutical formulations, fat-soluble drugs often have disadvantages such as low bioavailability and unstable absorption after administration, which greatly limits the clinical application of such drugs. The rapid development of nanotechnology and its application in pharmacy have obviously improved the deficiencies of fat-soluble drugs after administration. [0003] Generally, the size of nanoparticles in pharmacy is defined between 1 and 1000 nanometers, mainly including nanocarriers and nanomedicines. Nano-carrier system refers to encapsulating drugs in nanoparticles of different matrix materials by means of mosaic or adsorption, such as nanoliposomes, polymer nanocapsules, nanospheres, polymer micelles, etc.; Drug-processed nanoparticles. [0...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/14A61K47/14
Inventor 奉建芳何军陆伟根
Owner SHANGHAI INST OF PHARMA IND CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap