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Leather externally used paste

A skin external preparation, weight technology, applied in the field of skin external preparations, can solve problems such as no insight, and achieve good adaptability

Active Publication Date: 2005-08-31
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no insight regarding the solubilization of ascorbic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0111] Ascorbic acid 20

[0112] Trimethylglycine 3

[0113] Diethylene glycol monoethyl ether 52.4

[0114] Diglycerin 4

[0115] Purified water 20

[0116] Spice 0.5

[0117] Grapefruit Extract 0.1

[0118] ———————————————————————————————

[0119] Total 100%

Embodiment 4

[0121] Ascorbic acid 15

[0122] Trimethylglycine 3

[0123] Diethylene glycol monoethyl ether 50.9

[0124] Propylene glycol 20

[0125] Refined water 10

[0126] Diglycerin 1

[0127] Acerola Extract 0.1

[0128] ———————————————————————————————

[0129] Total 100%

Embodiment 5

[0131] Ascorbic acid 30

[0132] Trimethylglycine 9

[0133] Diethylene glycol monoethyl ether 30.9

[0134] Refined water 30

[0135] Orange Extract 0.1

[0136] ———————————————————————————————

[0137] Total 100%

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PUM

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Abstract

The present invention provides an external preparation for skin in which ascorbic acid or a salt thereof is stably solubilized. In an external preparation for skin containing ascorbic acid or a salt thereof, a glycol ether, or a specific polyhydric alcohol, ascorbic acid or a salt thereof can be stably solubilized by blending a low-molecular-weight glycine triglyceride. Therefore, it is possible to obtain a skin external preparation in which ascorbic acid or a salt thereof is stably blended at a high concentration, and ascorbic acid can effectively exhibit various inherent functions according to the blending amount. In addition, it is possible to prepare a formulation that does not give a sticky feeling after application to the skin, has a moist feeling, and has good adaptability to the skin.

Description

technical field [0001] The present invention relates to an external preparation for skin which stably solubilizes ascorbic acid or a salt thereof. Background technique [0002] Ascorbic acid is known to exhibit so-called anti-inflammatory effects, acne-improving effects, whitening effects, anti-aging effects, antioxidant effects, cell activation effects that promote the synthesis of biological components such as collagen, and inhibition of cell damage or DNA damage in epidermal keratinocytes by ultraviolet rays Various effects of the effect, and these effects are expected to be widely used as skin external preparations. However, ascorbic acid is easily oxidized in the presence of water in an aqueous solution, so it is sought to reduce the water in the preparation, but the problem is that a small amount of water cannot sufficiently dissolve ascorbic acid. For this reason, several methods for sufficiently dissolving ascorbic acid in water-based external skin preparations have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/375A61K45/06A61P17/00
Inventor 安野利佳子稻冈贤常次修一
Owner ROHTO PHARM CO LTD