Application of burdock glycoside or its aglycon in preparation of medicine for treating diabetes or its complications

A technology of arctigenin and arctiin, applied in drug combination, drug delivery, urinary system diseases, etc.

Inactive Publication Date: 2005-11-02
SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on the therapeutic active ingredients in Arctium Fructus. We found that both arctiin and arctigenin can reduce the blood sugar level of diabetic model animals, and can have a significant protective effect on renal function damage caused by diabetes, indicating that Arctium Glycosides and arctigenin can be used as drugs for clinical treatment of diabetes and diabetic nephropathy

Method used

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  • Application of burdock glycoside or its aglycon in preparation of medicine for treating diabetes or its complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0054] The formulation ratios below illustrate the dosage forms of the present invention

[0055] No. Component

Dosage

mg / tablet

mg / tablet

arctiin or arctigenin

Lactose USP

Cornstarch, 10 pure water slurry

cornstarch, food grade

Magnesium stearate

50

122

30

95

3

100

123

40

130

7

Total: 300

400

[0056] Manufacturing method

[0057] Mix items 1 and 2 in a suitable mixer for 15 minutes and granulate item 3 with the mixture. Grind the wet granulation through a primary sieve and allow to dry if necessary. If desired, sieve dry granules and mix with item 4 for 10-15 minutes. Add item 5 and mix for 1-3 minutes. The mixture is compressed to the appropriate size and weight in a suitable tablet press.

[0058] No.

components

Dosage

mg / tablet

mg / tablet

1

2

3

4

Arctiin (or Arctigenin)

La...

Embodiment 3

[0061] Example 3 Injection

[0062] Arctiin 10g or 50g

[0063] Physiological saline for injection 10000ml

[0064] Manufacturing method

[0065] Dissolve arctiin in an appropriate amount of physiological saline for injection at 60°C, add 0.05% injection and stir with activated carbon according to the prepared amount, let stand for 15 minutes, and filter through a 0.22 μm microporous membrane. Add water for injection to make the final volume 10000ml, and stir well. Take a sample to measure the pH value and content, filter it after passing the test, pot it and sterilize it by autoclaving at 115°C for 30 minutes.

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Abstract

The present invention provides the application of arctiin or arctigenin in preparing medicine for preventing and treating diabetes and its complication. The present invention also provides the application of arctiin or arctigenin in preparing medicine composition for preventing and treating diabetes and its complication, and the medicine composition may be administrated through oral taking, injection or local application.

Description

technical field [0001] The present invention relates to the application of arctiin or its aglycone in the preparation of medicines for treating diabetes and its complications, and also relates to a pharmaceutical composition containing arctiin or / and arctigenin. Background technique [0002] Diabetes is a group of common endocrine and metabolic syndromes that require life-long prevention and treatment. There are 100 million people with multiple diseases in the world, and there are currently about 20 million patients in my country. Currently, there is no cure for diabetes. It is a chronic hyperglycemia state caused by multiple genetic and environmental factors, and the clinical manifestation is hyperglycemia as the main common sign. The etiology and pathogenesis of diabetes are complex and have not been fully elucidated so far, and the effects of many treatments for diabetes are not very satisfactory. [0003] Generally speaking, when most patients with diabetes are diagnos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048
Inventor 王振华曲桂武苟海涛何杰
Owner SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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