Production of antiviral oral liquid

An antiviral oral liquid and new process technology, applied in the field of preparation process improvement, can solve problems such as easy volatilization, loss of volatile oil, loss of volatile components, etc., and achieve the effects of simple production process, increased stability, and improved curative effect

Active Publication Date: 2007-04-04
GUANGZHOU XIANGXUE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Forsythia, patchouli, calamus, and turmeric in the prescription contain volatile oils. According to literature reports, pharmacodynamic experiments have proved that patchouli alcohol (patiole alcohol) in the antiviral oral liquid has good antipyretic, Antibacterial effect, but the current extraction process uses water extraction and alcohol precipitation, and the extracted volatile components are directly added to the oral liquid. Since the volatile oil is less water-soluble and volatile, when the volatile oil is added to the filtrate, it will be used in potting and sealing. The volatile oil will be lost during the sterilization process, and as the storage time prolongs, the volatile components in the finished product will gradually be lost
Through the stability inspection, after the finished product was placed for 1 year, the content of its volatile oil (taking patchouli alcohol as the investigation index) decreased significantly. Therefore, the stability of the finished product was relatively poor, which may affect the original curative effect of the product; and because the volatile oil has a strong irritant Taste, affect the taste, unacceptable to children

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of antiviral oral liquid

[0024] 1. Extraction: Take 900g of Radix isatidis, 400g of gypsum, 425g of reed root, 225g of rehmannia, 175g of turmeric, 175g of Anemarrhena, calamus 175g, patchouli 200g, forsythia 325g, add 8 times the amount of water, heat and boil in the interlayer After 3 hours of extraction, 1953ml of volatile oil-containing emulsion was collected at the same time. The volatile oil was separated and collected by an oil-water separator to obtain 18ml of volatile oil and 1935ml of aromatic water for use. The extract is discharged through a horizontal spiral unloading filter centrifuge for use.

[0025] The medicine residue is extracted with 6 times the amount of water for 1 hour and 20 minutes, and the extract is discharged through a horizontal spiral unloading filter centrifuge, which is combined with the first extract for use. The medicine dregs are discarded.

[0026] 2. Concentration: Combine the extracts, concentrate in a vacuum be...

Embodiment 2

[0040] 1. Extraction: The operation is the same as in Example 1. 18ml of volatile oil and 1935ml of aromatic water are collected

[0041] 2. Concentration: The operation is the same as in Example 1, and the relative density is 1.09 (measured at 20°C), and 2100ml of antiviral concentrate is obtained.

[0042] 3. Preparation of inclusion compound: Take 150g of hydroxypropyl-βcyclodextrin to make a saturated aqueous solution, add 15ml of volatile oil dehydrated by anhydrous sodium sulfate, control the temperature at 40~60℃ and stir for 5 hours, the stirring speed is 300r / min , Get 238g of hydroxypropyl-β cyclodextrin inclusion solution. Inclusion rate is 85%

[0043] Fourth, with filter

[0044] After filtering 2100ml of antiviral concentrate, add 840g of honey, 1260g of sucrose, 238g of hydroxypropyl-β cyclodextrin inclusion solution, 1935ml of aromatic water, adjust the PH value to 5.10, mix well, filter until it is clear, add water to make up to volume 7000ml, constant volume liqu...

Embodiment 3

[0049] 1. Extraction: The operation is the same as in Example 1. 18ml of volatile oil and 1935ml of aromatic water are collected

[0050] 2. Concentration: The operation is the same as in Example 1, and the relative density is 1.09 (measured at 20°C), and 2100ml of antiviral concentrate is obtained.

[0051] 3. Preparation of inclusion compound: Take 45g of hydroxypropyl-βcyclodextrin to make a saturated aqueous solution, add 15ml of volatile oil dehydrated by anhydrous sodium sulfate, control the temperature at 40~60℃ and stir for 5 hours, the stirring speed is 300r / min , Get 80g of hydroxypropyl-β cyclodextrin inclusion solution. The inclusion rate is 50%.

[0052] Four, with filter:

[0053] Take 2100ml of antiviral concentrate and filter, add 840g of honey, 1260g of sucrose, 80g of hydroxypropyl-β cyclodextrin inclusion solution, 1935ml of aromatic water, adjust the pH to 5.10, mix well, filter until it is clear, add water to make up to 7000ml, constant volume liquid filtratio...

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PUM

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Abstract

An improved process for preparing the antiviral oral liquid with high content of volatile oil includes such steps as oil-water separation of the calpis containing volatile oil, including the volatile oil by water-soluble cyclodextrin to obtain included substance, mixing it with auxiliary, and filtering.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and specifically relates to the improvement of the preparation process of an antiviral oral liquid. Background technique [0002] The anti-viral oral liquid is a Chinese patent medicine approved by the Ministry of Health of the People’s Republic of China to be listed in the “Standards issued by the Ministry of Health of the People’s Republic of China” WS 3 -(X-39)-92(z), the product is a compound preparation, composed of nine traditional Chinese medicines, one of which is mineral gypsum and the other eight are botanicals. The prescriptions are Radix Isatidis 129g, gypsum 57g, and reed root 61g. Rehmannia glutinosa 32g, Turmeric 25g, Anemarrhena vulgaris 25g, Shichangpu 25g, Patchouli 29g, Forsythia 46g plus auxiliary materials, purified water to make 1000ml antiviral oral liquid. It is clinically used for viral infections such as upper respiratory t...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/9066A61P31/12A61K33/06
Inventor连林生康志英丘鸰原蔡春玲符方非
OwnerGUANGZHOU XIANGXUE PHARMA CO LTD