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Myostatin and mimetics thereof

a technology of myostatin and mimetics, applied in the field of myostatin, can solve problems such as increased muscle mass, and achieve the effect of prolonging the half-li

Inactive Publication Date: 2005-12-08
ORICO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0021] The use of such alternative structures can provide significantly longer half-life in the body, since they are more resistant to breakdown under physiological conditions.

Problems solved by technology

Targeted disruption of the myostatin gene in mice and a mutation in the third exon of myostatin gene in double-muscled Belgian Blue cattle, where a nonfunctional myostatin protein is expressed, leads to increased muscle mass.

Method used

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  • Myostatin and mimetics thereof
  • Myostatin and mimetics thereof
  • Myostatin and mimetics thereof

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Embodiment Construction

[0059] The present invention describes a bioassay for myostatin. Using this assay the inventors provide a means for identifying a mimetic of functional myostatin, i.e. a skeletal muscle growth inhibitor, comprising a part of the amino acid sequence of the functional myostatin protein, which will bind to myostatin receptors.

[0060] Growth inhibitor mimetics will act as ligands of the myostatin receptors in one or more in vitro or in vivo biological assays of myostatin activity.

[0061] One example of an in vitro biological assay of myostatin activity is the inhibition of proliferation of cultured myoblasts. The addition of an effective amount of at least one growth inhibitor mimetic of the invention will inhibit the proliferation of the myoblasts.

[0062] One example of an in vivo biological assay of myostatin activity is the reduction of the muscle mass in either normal or in myostatin null mice. The administration thereto of an effective amount of at least one growth inhibitor mimeti...

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Abstract

An isolated mimetic of functional myostatin comprising part of the amino acid sequence of functional myostatin, such that the mimetic is capable of inhibiting muscle growth.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a Divisional of U.S. application Ser. No. 10 / 181,545 filed Nov. 20, 2002, which is the U.S. National Phase under 35 U.S.C. § 371 of International Application No. PCT / NZ01 / 00005, filed Jan. 18, 2001 and designating the United States and published in English, which claims priority to New Zealand Application No. 502389, filed Jan. 18, 2000, all of which are hereby expressly incorporated by reference in their entireties.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] This invention relates to myostatin, particularly, although by no means exclusively, to mimetics for functional myostatin and non-functional myostatin; their therapeutic use and to a method for identifying such mimetics. [0004] 2. Description of the Related Art [0005] All references, including any patents or patent applications, cited in this specification are hereby incorporated by reference. No admission is made that any reference const...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61P21/00C07K14/475C07K14/51C07K14/71
CPCA61K38/00C07K14/475A61P21/00
Inventor BASS, JAMES JOHNSTONBERRY, CAROLE J.KAMBADUR, RAVISHARMA, MRIDULATHOMAS, MARK F.
Owner ORICO