Pharmaceutical composition and health food comprising extract of Phellinus sp. PL3 or phellinsin a isolated from the same as an effective component for prevention and treatment of cardiovascular disease
Inactive Publication Date: 2006-06-01
KOREA RES INST OF BIOSCI & BIOTECH
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- Abstract
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- Application Information
AI Technical Summary
Benefits of technology
[0010] The inventors of the present invention have made extensive efforts to find a natural product which meets the practical requirement as an LDL anti-oxidant by screening various natural products. As a consequence, they have discovered that Phellinus sp. PL3 extract or phellinsin A isolated from the same inhibits the oxidation of low density lipoprotein (LDL). Further, they can be used in manufacturing a pharmaceutical drug and health food comprising Phellinus sp. PL3 extract or phellinsin A as an effective component useful in prevention and
Problems solved by technology
The formation of plague inside the wall of a blood vessel wall and its rupture is a major cause to bring about myocardial infarction.
However, they are known to have a few adverse actions and thus have been limited in their administration.
Method used
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Experimental program
Comparison scheme
Effect test
example 3
Preparation of Methanol Extract of Phellinus sp. PL3
[0040] 10 L of culture broth of Phellinus sp. PL3 obtained in Example 2 was added to the same volume of methanol, extracted twice and concentrated under reduced pressure to produce a solvent extract in an oilic form.
example 4
Preparation of Methanol and Ethyl Acetate Extract of Phellinus sp. PL3
[0041] 10 L of culture broth of Phellinus sp. PL3 obtained in Example 2 was added to the same volume of methanol, extracted twice and concentrated under reduced pressure to produce a solvent extract in an oilic form. Then, the resulting extract was extracted twice by using ethyl acetate to produce a solvent extract in an oil state.
example 5
Preparation of Ethyl Acetate Extract of Phellinus sp. PL3
[0042] 10 L of culture broth of Phellinus sp. PL3 obtained in Example 2 was added to the same volume of ethyl acetate, extracted twice and concentrated under reduced pressure to produce a solvent extract in an oilic form.
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Abstract
The present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component. More particularly, the present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component, wherein the Phellinus sp. PL3 extract and its phellinsin A inhibit the oxidation of low density lipoprotein (LDL), and further, they can be used as a component for medicine and food to effectively prevent and treat cardiovascular diseases such as hyperlipemia and arteriosclerosis.
Description
CROSS REFERENCE TO RELATED APPLICATION [0001] This application is based on, and claims priority from Korean Patent Application No. 10-2004-0099339, filed on Nov. 30, 2004, the disclosure of which is hereby incorporated by reference. BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component. More particularly, the present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component, wherein the Phellinus sp. PL3 extract and its phellinsin A inhibit the oxidation of low density lipoprotein (LDL). Further, they can be used as active ingredients for manufacturing medicines and food to prevent and treat cardiovascular diseases such as hyperlipemia and arteriosclerosis. [0004] 2. Background of the...
Claims
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Login to View More IPC IPC(8): A61K36/07A61K31/365
CPCA23C15/12A23L1/24A23L1/3002A23L1/31436A23L1/39A23L2/02A23L2/52A61K31/365A61K36/07A23L27/60A23L33/105A23L13/426A23L23/00A61P3/06A61P9/10A61K36/074
Inventor KIM, SUNG UKHWANG, EUI ILKIM, JU RYOUNGJEONG, TAE SOOKLEE, SANGKULEE, SANG HANMOON, JAE SUNRHO, MUN-CHUAL
Owner KOREA RES INST OF BIOSCI & BIOTECH