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Use for budesonide and formoterol

Inactive Publication Date: 2006-08-24
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chronic bronchitis can lead to more frequent and severe respiratory infections, narrowing and plugging of the bronchi, difficult breathing and disability.
These enlarged areas trap stale air and do not effectively exchange it with fresh air.
This results in difficult breathing and may result in insufficient oxygen being delivered to the blood.
The problem with these treatments is that none of them is especially effective.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] 6 Parts by weight of formoterol fumarate dihydrate was mixed with 794 parts. by weight of lactose monohydrate. The blend was micronised using a high pressure air jet mill and then conditioned using the process of EP-A-717 616. 200 Parts by weight of micronised budesonide was added to the conditioned product by mixing and homogenising with a low pressure jet mill. The mixture was then spheronised using the process of EP-A-721 331 and filled into the storage compartment of a Turbuhaler.

example 2

[0037] 4.5 Parts by weight of formoterol fumarate dihydrate was mixed with 835 parts by weight of lactose monohydrate. The blend was micronised using a high pressure air jet mill and then conditioned using the process of EP-A-717 616. 160 Parts by weight of micronised budesonide was added to the conditioned product by mixing and homogenising with a low pressure jet mill. The mixture was then spheronised using the process of EP-A-721 331 and filled into the storage compartment of a Turbuhaler.

example 3

[0038] 12 Parts by weight of formoterol fumarate dihydrate was mixed with 588 parts by weight of lactose monohydrate. The blend was micronised using a high pressure air jet mill and then conditioned using the process of EP-A-717 616. 400 Parts by weight of micronised budesonide was added to the conditioned product by mixing and homogenising with a low pressure jet mill. The mixture was then spheronised using the process of EP-A-721 331 and filled into the storage compartment of a Turbuhaler.

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Abstract

The invention provides the use of formoterol and budesonide in the treatment of chronic obstructive pulmonary disease.

Description

FIELD OF THE INVENTION [0001] The invention provides the use of formoterol and budesonide in the treatment of chronic obstructive pulmonary disease (COPD). BACKGROUND OF THE INVENTION [0002] Chronic obstructive pulmonary disease (COPD) is a term which refers to a large group of lung diseases which can interfere with normal breathing. It is estimated that 11% of the U.S. population has COPD and the incidence is increasing. The two most important conditions covered by COPD are chronic bronchitis and emphysema. [0003] Chronic bronchitis is a long-standing inflammation of the bronchi which causes increased production of mucous and other changes. The patients' symptoms are cough and expectoration of sputum. Chronic bronchitis can lead to more frequent and severe respiratory infections, narrowing and plugging of the bronchi, difficult breathing and disability. [0004] Emphysema is a chronic lung disease which affects the alveoli and / or the ends of the smallest bronchi. The lung loses its e...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K31/16A61K9/72A61K31/166A61K31/167A61K31/57A61K31/58A61P11/00A61P11/08
CPCA61K31/16A61K31/167A61K31/58A61K31/165A61K2300/00A61P11/00A61P11/08A61K31/57
Inventor BAUER, CARL-AXELTROFAST, JAN
Owner ASTRAZENECA AB