Inhibitors of phosphodiesterases in infertility

a technology of phosphodiesterases and infertility, which is applied in the field of inhibitors of phosphodiesterases in infertility, can solve the problems of producing ovarian hyperstimulation syndrome (ohss), affecting the development of ovarian follicles, and affecting the development of ovaries, so as to stimulate follicle growth and maturation, stimulate follicle growth and increase follicle maturation, the effect o
US20060229288A1Inactive Publication Date: 2006-10-12LAB SERONO SA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
LAB SERONO SA
Publication Date
2006-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation using a PDE inhibitor. The inhibitor may be used alone at high doses. Alternatively, the follicular maturation is achieved by combining a low dose of FSH with the PDE inhibitor treatment.
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Description

[0001] This application is a continuation of U.S. patent application Ser. No. 10 / 817,312, filed Apr. 1, 2004, and which claims the benefit of U.S. Provisional Application No. 60 / 458,955, filed Apr. 1, 2003, U.S. Provisional Application No. 60 / 470,434, filed May 15, 2003, U.S. Provisional Application No. 60 / 540,301, filed Jan. 28, 2004, and U.S. Provisional Application No. 60 / 544,003, filed Feb. 12, 2004, each of which is incorporated by reference herein in its entirety.FIELD OF INVENTION

[0002] The present invention is generally directed to reproductive biology and assisted reproductive technologies (ART), such as controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). More specifically, the present invention is directed to methods and compositions for inducing follicle maturation in vivo using one or more phosphodiesterase inhibitors either alone or in combination with one or more gonadotropins, including the stimulation of follicle maturation for purposes such ...

Claims

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