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Method for determining the prognosis of cancer patients by measuring levels of bag expression

a cancer patient and expression method technology, applied in the field of determining the risk of progression or spread of cancer, can solve the problems that the doctors are still unable to accurately predict the course of disease for all breast cancer patients, and achieve the effect of determining the prognosis of disease free or overall survival, high levels or “overproduction”

Inactive Publication Date: 2008-07-10
SANFORD BURNHAM MEDICAL RES INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]In accordance with the present invention, there are provided methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. In one embodiment, it has been found that high levels or “overproduction” of BAG proteins in primary tumor tissue show an unexpected and surprisingly high correlation with lack of tumor recurrence or spread, and therefore long-term disease free or overall survival.

Problems solved by technology

However, even with these additional factors, practitioners are still unable to accurately predict the course of disease for all breast cancer patients.
But since the majority (about 70%) of these patients enjoy long-term survival following surgery and / or radiotherapy without further treatment, it may be inappropriate to recommend adjuvant therapy for all of these patients.

Method used

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  • Method for determining the prognosis of cancer patients by measuring levels of bag expression
  • Method for determining the prognosis of cancer patients by measuring levels of bag expression
  • Method for determining the prognosis of cancer patients by measuring levels of bag expression

Examples

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examples

1.0 BAG1 Immunostaining Predicts Longer Survival in Breast Cancer Patients with Tumor-Negative Lymph-Nodes

[0077]The role of BAG1 (also known as RAP46 and HAP-1) immunostaining for prognostic evaluation of women with breast cancer was assessed for patients with negative lymph-node biopsies (i.e. no evidence of tumor in axillary nodes which have been surgically removed for histological examination) by analysis of a cohort of women with stage-I disease. This example illustrates the determination of the reference level of BAG-1 expression in breast cancer patients, and evaluation of the accuracy of the reference level in predicting disease-free or overall survival of separate groups having different BAG-1 expression levels.

[0078]A retrospective correlative analysis was performed of BAG-1 using a monoclonal antibody capable of detecting BAG-1N, BAG-1M and BAG-1L (see Takayama et al., 1998, supra). Estrogen Receptor (ER), Progesterone Receptor (PR), HER2 / Neu, p53, Bcl-2, Bax, which have a...

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Abstract

In accordance with the present invention, there are provided methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. Also provided are methods for predicting the risk of tumor recurrence or spread in an individual having a cancer tumor. Methods for screening a cancer patient to determine the risk of tumor metastasis; methods for determining the proper course of treatment for a patient suffering from cancer; and kits for use in practicing the invention methods.

Description

[0001]Portions of the invention described herein were made in the course of research supported in part by NIH grant CA-67329. The Government may have certain rights in this invention.FIELD OF THE INVENTION[0002]The present invention relates generally to determining the risk of progression or spread of cancers.BACKGROUND INFORMATION[0003]Prognosis in clinical cancer is an area of great concern and interest. It is important to know the aggressiveness of the malignant cells and the likelihood of tumor recurrence or spread in order to plan the most effective therapy. Breast cancer, for example, is managed by several alternative strategies. One of every nine women currently develops breast cancer at some point in her life. In some cases local-regional therapy is utilized, consisting of mastectomy or lumpectomy with or without radiation, while in other cases when spread of disease is detected or suspected, systemic therapy is instituted, such as chemotherapy or hormonal therapy. Among wom...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68C12Q1/00G01N33/483G01N33/53G01N33/574
CPCC12Q1/6886C12Q2600/158C12Q2600/118G01N2800/52G01N33/57407
Inventor REED, JOHN C.
Owner SANFORD BURNHAM MEDICAL RES INST
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