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71results about How to "Long-term survival" patented technology
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Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
ActiveUS7598287B2Reduce loadIncrease in CDHeavy metal active ingredientsBiocideDioxygenaseCancer research
The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.
Owner:GEORGIA HEALTH SCI UNIV RES INST
Modulators of 5'-nucleotidase, ecto and the use thereof
ActiveUS20170267710A1Increase the delayed-type hypersensitivity reaction to tumor antigenDelay the time-to-relapse of post-transplant malignancyAntibacterial agentsNervous disorderDiseaseNucleotidase
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and / or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
Owner:ARCUS BIOSCI INC
Novel probiotic strain and application thereof
ActiveCN102191189AIncrease resistanceHigh sporulation rateCosmetic preparationsBacteriaBiotechnologyIntestinal structure
The combination of probiotics and food is helpful for inhibiting the growth of pathogens and absorbing special nutritions. However, the probiotics need to survive at high temperature in the process of food processing, and after the probiotics enter the body, the probiotics must go through the test of stomach acid and bile salt to reach the intestines. Accordingly, the invention provides a bacillus subtilis strain BS139, which is characterized by the survivability of resisting environmental stresses, including the characteristics such as acid resistant, bile salt resistant, high temperature resistance and the like. The probiotic strain is preserved in Agricultural Research Service, NRRL and has a preservation number of NRRL No.B-50347, with further applications in the preparation of food commodities, pharmaceutical compositions, and daily necessities.
Owner:林秀霞
Tissue-engineered skin containing blood vessels and hair follicle structures based on 3D printing and preparation method thereof
ActiveCN108525021ASimple structureIncrease elasticityAdditive manufacturing apparatusTissue regenerationMicrosphereVascular endothelium
The invention relates to tissue-engineered skin containing blood vessels and hair follicle structures based on 3D printing and a preparation method thereof. The tissue-engineered skin is composed of an epidermal layer, an acellular dermal scaffold and a dermis layer, wherein in the epidermal layer, epidermal stem cells are used seed cells, the seed cells are printed on the upper surface of the acellular dermal scaffold through a 3D printer after being compounded with a hydrogel carrier to differentiate and form a normal epidermal structure, in the dermis layer, mesenchymal stem cells, vascularendothelial cells, dermal papilla cells and adipose-derived stem cells are used as seed cells, the seed cells and a hydrogel carrier are compounded, through the 3D printer, gelatin slow-release micropheres compounded with cytokines are printed on the lower surface of the acellular dermal scaffold, and meanwhile, the hydrogel compound of the seed cells is printed in the gelatin slow-release micropheres to form a dermis structure with a three-dimensional spatial structure.
Owner:SHANXI MEDICAL UNIV
Modulators of 5′-nucleotidase, ecto and the use thereof
ActiveUS10239912B2Increase the delayed-type hypersensitivity reaction to tumor antigenDelay the time-to-relapse of post-transplant malignancyBiocideNervous disorderDiseaseNucleotidases
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and / or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
Owner:ARCUS BIOSCIENCES INC
Microorganism-containing fertilizer produced by mycoderm method and production method of fertilizer
The invention provides to a microorganism-containing fertilizer produced by a mycoderm method and a production method of the fertilizer. In the prior art, microorganism bactericides, organic matters, chemical fertilizer and the like are mixed according to a preset formula, and the mixture is subjected to granulation, high-temperature drying, screen separation, cooling and the like so as to produce a finished product. In the production method provided by the invention, the fertilizer without bactericides is granulated, dried, screened and cooled; active bacterium powder is coated on the outer surface of the fertilizer particles at the tail end of the production line by using a film technology; and the microbial content of the whole fertilizer when in detection reaches the technical standard of national regulation so that a film fertilizer is formed. The method provided by the invention is used for producing the fertilizer with active bacterium.
Owner:杨庆理
Humanized animals via tissue engineering and uses thereof
Engineered human tissue constructs are provided that are suitable for use in making humanized animals for use in pharmaceutical development. Humanized animals having the constructs implanted in vivo are provided. Methods of making and using the tissue-engineered constructs and humanized animals are also provided.
Owner:MASSACHUSETTS INST OF TECH
Use of Inhibitors of Indoleamine-2,3-Dioxygenase in Combination with Other Therapeutic Modalities
ActiveUS20090081155A1Reduction in viral loadIncrease in CD4+ T cell countBiocidePeptide/protein ingredientsCancer researchDioxygenase
The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.
Owner:GEORGIA HEALTH SCI UNIV RES INST
Process for producing Metarrhizium anisopliae non-woven fabric ribbon
InactiveCN1419823AHigh field lifeExtend your lifeBiocideAnimal repellantsMicrobiologyBacterial strain
A process for preparing a non-woven disinfecting strip of Metarrhizium anisopliae includes sampling the bacterial strain, slant culture, liquid culture, production with fermentor, and inoculating the Metarrhizium anisopliae to non-woven strips. Its advantages are high and durable effect on pests (such as longicorn), low cost and no environmental pollution.
Owner:JIANGXI TIANREN ECOLOGY
Special fertilizer for commercial crops planted in saline and alkaline land as well as preparation method and application of fertilizer
InactiveCN108299072AHigh porosityImprove buffering effectAlkali orthophosphate fertiliserAmmonium orthophosphate fertilisersAlkali soilPlant growth
The invention discloses special fertilizer for commercial crops planted in saline and alkaline land as well as a preparation method and an application of the fertilizer. The fertilizer is prepared from peat soil, fulvic acid, compound fertilizer, bacillus subtilis spores, amino acid, a rooting agent, medium trace element fertilizer and attapulgite clay. The special improvement fertilizer which isused for planting of fresh sunflower and is prepared through proportion optimization of the materials and granulation with the attapulgite clay added to serve as a binder has multiple effects of providing special fertilizer effects, improving the soil quality, increasing the survival rate of beneficial bacteria, improving the resistance of crops, improving nutrient balance and the like after beingapplied to the saline and alkaline land. The special improvement fertilizer takes organic-inorganic compound fertilizer as the core, adsorbs concentrated bacillus subtilis spores, amino acid and plant growth regulator, granulation is performed through a disk granulating machine or an extruding granulating machine, and large-scale, mechanical and light popularization and application of the fertilizer are facilitated.
Owner:INST OF SOIL SCI CHINESE ACAD OF SCI +1
Concrete self-repairing material, and preparation method thereof and concrete with concrete self-repairing material
InactiveCN113149496AIncreased durabilityExtended service lifeCalcium/strontium/barium carbonatesMicroorganismInorganic particle
Owner:JIANGSU UNIV OF SCI & TECH
Freezing and thawing of MDCK cell
InactiveCN105994255APrevent excessive cell damageGood cell viabilityDead animal preservationArtificial cell constructsCellular viabilityCellular death
The invention relates to freezing and thawing of MDCK cell, and relates to freezing and thawing of the MDCK cell. The freezing method comprises the following steps: by restricting the addition rate of the frozen stock solution in mixing of a frozen stock solution and the cell, cell damage is prevented, by adjusting the cooling rate, generation of ice crystal in the cell can be prevented, and cell death is lead. In cell thawing, thawing can be rapidly carried out, and integrity and survival rate of the cell can be guaranteed. The method can better keep the MDCK cell vitality. The cell vitality after thawing can reach more than 95%, the cell quality is guaranteed, and long-term viability of the cell can be guaranteed.
Owner:哈尔滨市疾病预防控制中心
Method for making primate dry age-related macular degeneration disease model
InactiveCN103720524AIncrease concentrationControl timeVeterinary instrumentsIodine compound active ingredientsDiseasePrimate
The invention discloses a method for making a dry age-related macular degeneration disease model on a primate, namely applying sodium iodate onto the primate with a carotid artery injection method. The method is simple and easy, high in success rate and good in repeatability. The model made with the method is stable. The amount of sodium iodate needed is small, injury of large doses of sodium iodate to the whole body of the animal is avoided, and the animal can live for a long time so that follow-up tests can be made possible. A model of any one side or a model of double sides can be made as needed. When the one-side model is made, a lateral eye can not be hurt at all, and normal living vision of the animal is guaranteed. Comparison of two lateral eyes of one animal can be conducted to provide credibility for the test, and the number of animals needed for the test is reduced. The method provides a sound tool for the dry age-related macular degeneration research and has great significance for the pathological physiology research and treatment research of the disease.
Owner:JIANGSU PROVINCE HOSPITAL
Method for repairing DEHP contaminated soil and lowering DEHP content in growing vegetables with Microbacterium sp.J-1
ActiveCN106799390ARealize the repair effectStrain SurvivalBacteriaContaminated soil reclamationContaminated soilsRoot system
The invention discloses a method for repairing DEHP contaminated soil and lowering the DEHP content in growing vegetables with Microbacterium sp.J-1. In particular, flowering cabbage is planted in the DEHP contaminated soil, and a Microbacterium sp.J-1 strain is inoculated around a root system of the flowering cabbage. If the Microbacterium sp.J-1 strain is only inoculated into the DEHP contaminated soil, a persistent repairing effect cannot be achieved for the reason that the Microbacterium sp.J-1 strain can die with the extension of inoculation time. However, if the Microbacterium sp.J-1 strain is inoculated into the DEHP contaminated soil, and meanwhile the flowering cabbage is planted, the root system environment of the flowering cabbage provides available organic matter for the Microbacterium sp.J-1 strain, the inoculated strain can survive in the soil for a long time, and the persistent repairing effect on the contaminated soil can be achieved. Meanwhile, the flowering cabbage with the quality safety up to the standard can be planted, and the mode of 'repairing while production' is realized.
Owner:JINAN UNIVERSITY
Implantable human liver tissue constructs and uses thereof
Engineered human tissue constructs are provided that are suitable for use in making humanized animals for use in pharmaceutical development. Humanized animals having the constructs implanted in vivo are provided. Methods of making and using the tissue-engineered constructs and humanized animals are also provided.
Owner:MASSACHUSETTS INST OF TECH
Parenterally administered immune enhancing drugs
PendingUS20200405629A1Good for survivalShrink tumorOrganic active ingredientsPharmaceutical delivery mechanismDiseaseNucleotidase
Methods of identifying compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and that possess particular pharmacokinetic characteristics are described herein. Methods of such compounds, and compositions comprising same, for the treatment and / or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, are also provided.
Owner:ARCUS BIOSCI INC
Anti-saline-alkali aspergillus ochratensis strain W1 and micro-organism agent thereof, and applications of anti-saline-alkali aspergillus ochratensis strain W1
ActiveCN110499254ALong-term survivalHas salt-resistant propertiesFungiContaminated soil reclamationHigh sodiumMicroorganism
The present invention relates to anti-saline-alkali aspergillus ochratensis strain W1 and a micro-organism agent thereof, and applications of the anti-saline-alkali aspergillus ochratensis strain W1.The strain is aspergillus ochratensis preserved in China General Microbiological Culture Collection Center and has a preservation name of aspergillus ochratensis W1 and a preservation number of CGMCCNO.17971. The anti-saline-alkali aspergillus ochratensis strain W1 can stably survive in the soil with high sodium salt concentration and high pH, effectively degrades straws and is suitable for rebuilding saline-alkali land.
Owner:JILIN UNIV
Process for producing metarrhizium anisopliae non-woven fabric ribbon
InactiveCN1212772CLong-term survivalSlow resistance developmentBiocideAnimal repellantsMicrobiologyBacterial strain
A process for preparing a non-woven disinfecting strip of Metarrhizium anisopliae includes sampling the bacterial strain, slant culture, liquid culture, production with fermentor, and inoculating the Metarrhizium anisopliae to non-woven strips. Its advantages are high and durable effect on pests (such as longicorn), low cost and no environmental pollution.
Owner:JIANGXI TIANREN ECOLOGY
Inhibitors of adenosine 5'-nucleotidase
ActiveUS20200222441A1Reduce viral loadProlong survival timeOrganic active ingredientsNervous disorderDiseaseNucleotidase
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and / or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
Owner:ARCUS BIOSCI INC
An organic decomposition agent, a preparing method thereof and applications of the agent
ActiveCN107893042ASolve problems that are processed quicklyReduce labor intensityFungiBio-organic fraction processingSnow moldBacillus licheniformis
The invention relates to the technical field of biology, and particularly provides an organic decomposition agent, a preparing method thereof and applications of the agent. The agent is mainly prepared from bacillus licheniformis, bacillus subtilis, AC yeast, trichoderma and streptomyces. The strains are mutualistic and comprehensively exert functions of each strain. An issue of rapid treatment oforganic matters such as straw can be effectively solved, resources are reasonably utilized, soil nutrients can be supplemented and balanced, soil is improved, labor intensity of farmers is reduced and environment pollution is reduced. In addition, the strains have high disease resistance, can survive for long time in hostile environment, and have good control effects on fusarium wilt, verticillium wilt, and the like.
Owner:宁夏天瑞绿色种业有限公司
Ganoderma lucidum biological layer feed
InactiveCN103719538APlay a synergistic roleLong-term survivalAnimal feeding stuffImmunocompetenceCholesterol
The invention relates to a ganoderma lucidum biological layer feed and belongs to a layer feed. The layer feed comprises 2-5% of number 001 ganoderma lucidum liquid, 10-20% of corn and 75-88% of energy grass meal, wherein the number 001 ganoderma lucidum liquid is mixed bacterium liquid and comprises alactic acid bacteria, saccharomycete and actinomycetes; a living environment is clean water; white sugar is added into the clean water to prepare living liquid; a ratio of the water to the sugar is 20:1; an ambient temperature is between 5 DEG C and 35 DEG C; the lactic acid bacteria, the saccharomycete and the actinomyces are 1g respectively and can live after added into the living liquid; and the energy grass meal comprises giant energy grass or giant bacterium grass. The feed has the advantages that the grass replaces grain, so that the feed is saved; the grain utilization is reduced; the feed cost is lowered; the immunocompetence of an animal is greatly improved; a meat factor of the animal and a laying rate of poultry are increased; 87.1% of fat in the animal is decomposed; above 70% of cholesterol is reduced; the meet activity is improved; and the meat factor is increased by above 20%. The detection shows that the cholesterol in an egg is reduced by 73%, lecithin is increased by 170.71%, eight essential amino acids for a human body are increased by 36.89%, and glutamic acid is increased by 52.7%.
Owner:钦州福德培植生物研究所
Method for determining the prognosis of cancer patients by measuring levels of bag expression
InactiveUS20080166733A1Prognosis of freeFree survivalMicrobiological testing/measurementPreparing sample for investigationDiseaseAbnormal tissue growth
In accordance with the present invention, there are provided methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. Also provided are methods for predicting the risk of tumor recurrence or spread in an individual having a cancer tumor. Methods for screening a cancer patient to determine the risk of tumor metastasis; methods for determining the proper course of treatment for a patient suffering from cancer; and kits for use in practicing the invention methods.
Owner:SANFORD BURNHAM MEDICAL RES INST
Crystalline forms of a cd73 inhibitor and uses thereof
ActiveUS20210395291A1Prolong survival timeLong-term survivalOrganic active ingredientsSugar derivativesCrystallographyDisease
Crystalline forms of the compound of Formula (I), which modulates the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compound and methods for preparing the crystalline forms, are described herein. The use of such crystalline form of Formula (I) and compositions for the treatment and / or prevention of a diverse array of diseases, disorders and conditions, including cancer and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
Owner:ARCUS BIOSCI INC
Nuclear waste capsule container system
ActiveUS20200027605A1Process safetyLong-termPortable shielded containersRadioactive decontaminationEnvironmental engineeringIgneous rock
Capsule systems and methods for long-term storage and / or disposal of high-level nuclear waste in deep geologic formations are described. Such systems and methods may include waste-capsules constructed substantially from granite or similar igneous rock material into which the nuclear waste material is placed before capsule insertion into a geologically deep wellbore.
Owner:CRICHLOW HENRY
Nuclear waste capsule container system
ActiveUS11289226B2Process safetyLong-termPortable shielded containersRadioactive decontaminationEnvironmental engineeringIgneous rock
Capsule systems and methods for long-term storage and / or disposal of high-level nuclear waste in deep geologic formations are described. Such systems and methods may include waste-capsules constructed substantially from granite or similar igneous rock material into which the nuclear waste material is placed before capsule insertion into a geologically deep wellbore.
Owner:CRICHLOW HENRY
Protein composite scaffold capable of self-producing oxygen, and preparation method thereof
The invention provides a protein composite scaffold capable of self-producing oxygen. The protein composite scaffold capable of self-producing oxygen comprises bioprotein, gelatin and an oxygen self-producing material. A mass ratio of the gelatin to the bioprotein is (0.5-5):10 and a mass ratio of the oxygen self-producing material to the bioprotein is (1-50):10. The protein composite scaffold capable of self-producing oxygen is compounded from the bioprotein, the gelatin and the oxygen self-producing material, and has physical strength superior to a membrane structure material constructed by using a pure protein combined solution. Meanwhile, the gelatin has a certain coating effect on the oxygen self-producing material, so that the provided protein composite scaffold can release oxygen at a constant speed and a high level; seed cells compounded on the protein composite scaffold can survive for a long time and microvessel ingrowth after the material is implanted is promoted. The protein composite scaffold is suitable for requirements of actual surgery operations, and finally increases success rate of urethral repair and reconstruction.
Owner:SHANGHAI SIXTH PEOPLES HOSPITAL
Hyaluronic acid oligosaccharide modified mineralization collagen bionic bone repair material
ActiveCN110639063APromote migrationSimple methodMicrobiological testing/measurementElectro-spinningCell migrationOligosaccharide
Owner:SHANDONG UNIV
Landscape water-culture fish-vegetable coexistence method
InactiveCN109644906AImprove landscapeSufficient quantityMagnesium fertilisersAmmonium salt fertilisersAquaponicsPhosphate
The invention provides a landscape water-culture fish-vegetable coexistence method and relates to the technical field of aquaculture and soilless cultivation. Fish-vegetable coexistence nutritional liquid comprises calcium nitrate, potassium dihydrogen phosphate, potassium sulfate, magnesium sulfate, potassium nitrate, chelated iron, boric acid, manganese sulfate, zinc sulfate, copper sulfate, ammonium molybdate and water, so that vegetables can be ensured to get nutrient; fish-type edible vegetable root systems are added, and additional feeding of feed is not needed, so that water cleanlinessis ensured to enable fishes to survive for a long time. A fish-vegetable coexistence state using the nutritional liquid prepared from chemical preparations, with fishes and vegetable root systems ina same space and having good landscape effect is formed finally. By applying the fish-vegetable coexistence nutritional liquid and combining with nutritional liquid parameter control and a proper fish-vegetable coexistence planting and breeding system, the fishes directly growing in the nutritional liquid can survive normally for a long time, and vegetables can normally grow.
Owner:王加倍
Gene therapy composition for use in diabetes treatment
ActiveUS20160074534A1Improved glucose utilizationPrevent chronic hyperglycemiaSugar derivativesPeptide/protein ingredientsCanis lupus familiarisCancer research
New gene therapy constructions and compositions are the subject of present invention. The gene therapy compositions consist in adeno-associated vectors which jointly express insulin (Ins) and glucokinase (Gck) genes. The new gene therapy constructions are useful for treatment of diabetes either in dogs or human beings.
Owner:UNIV AUTONOMA DE BARCELONA
Extraction method of active factor for improving survival rate of transplanted autologous fat such as autologous fat living cells
PendingCN111840643ALong-term survivalConducive to survivalPharmaceutical delivery mechanismTissue regenerationHydroxyethyl starchEngineering
The invention relates to an extraction method of an active factor for improving a survival rate of transplanted autologous fat such as autologous fat living cells, which comprises the following steps:1) putting extracted adipose tissue mixed liquid into a test tube, centrifuging, sucking supernatant plasma on the uppermost layer, adding a hydroxyethyl starch solution, and sufficiently and uniformly mixing, 2) adding into a nucleic acid type fermentation liquid, adding normal saline, stirring, standing, extracting fermentation liquid supernatant by using a sterile injector, adding a cryopreservation liquid into the fermentation liquid supernatant, and freezing by using semiconductor refrigeration equipment, (3) carrying out centrifugal operation by using a freezing centrifugal machine, after the fermentation liquor is liquefied again, adding the liquid after standing into a centrifugal tube, and carrying out secondary centrifugal treatment on the centrifugal tube in the centrifugal machine, 4) after centrifugal filtration, putting into a refrigerated centrifuge for centrifugal operation, and adding a new plasma sample to enable precipitated platelets to suspend again to obtain theactive factor. By means of the method, original adipose cells can be promoted to continue to grow and finally become adipose tissue stably, and the survival rate is high.
Owner:乔爱军
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