Therapeutic compounds and their use in the prevention and treatment of
disease are disclosed. The compounds include one or more materials selected from algal
biomass / supernatants (including both
algae and
bacteria), bacterial
biomass, and isolated and purified compounds, as well as specific active sites or structures on those compounds. Therapeutic compounds derived from
bacteria that appear to selectively alter one or more TLR pathways and the use of such compounds in the prevention and treatment of
disease in both animals and humans. The
bacteria are selected from the group consisting of Algoriphagus sp., Bosea sp., Brevundimonas sp.,
Desulfovibrio sp.,
Microbacterium sp.,
Sphingomonas sp., and Variovorax sp. The disclosed compounds and methods of treatment find particular use in treating diseases in poultry, particularly in the prevention and treatment of
coccidiosis.