Microbacterium, broad spectrum glycosaminoglycan lyase expressed by microbacterium, and coding gene and applications of broad spectrum glycosaminoglycan lyase

A technology of microbacteria and bacterial strains, applied in the field of microbacteria, can solve problems such as no glycosaminoglycan lyase
CN106906161AActive Publication Date: 2017-06-30济南唐泰生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
济南唐泰生物科技有限公司
Publication Date
2017-06-30

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Abstract

The present invention relates to microbacterium, broad spectrum glycosaminoglycan lyase expressed by the microbacterium, and a coding gene and applications of the broad spectrum glycosaminoglycan lyase. According to the present invention, the Microbacterium sp. WS15 strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 05, 2016, and has the preservation number of CGMCC No.13421, wherein the address is Institute of Microbiology, Chinese Academy of Sciences, 3# Court No.1, Beichen West Road, Chaoyang District, Beijing; and the glycosaminoglycan lyase TT16 is firstly obtained from the genome of Microbacterium WS15, can degrade the hyaluronic acid with no sulfation modification, can further degrade chondroitin sulfate A (CS-A), chondroitin sulfate C (CS-C) and chondroitin sulfate E (CS-E) being subjected to different sulfation modifications, and is the broad spectrum glycosaminoglycan lyase.
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Description

Technical field

[0001] The invention relates to a microbacterium, a broad-spectrum glycosaminoglycan lyase expressed by the bacterium and its coding gene and application, and belongs to the field of biotechnology. Background technique

[0002] Glycosaminoglycan (GAGs), also known as amino polysaccharides, acid mucopolysaccharides, etc., are linear polysaccharides formed by the polymerization of repeating disaccharide structural units [1] . They are widely present in animal connective tissues, and most of them exist in the body by covalently bonding with core proteins to form proteoglycans.

[0003] GAGs can be divided into hyaluronic acid (HA), heparin (HP), and heparin sulfate (HS) according to their monosaccharide composition, glycosidic bond connection form, and the degree and position of sulfation. , Chondroitin sulfate (CS), dermatan sulfate (DS) and kermatan sulfate (KS) [2] . The structure of HA is relatively simple. The disaccharide unit composed of D-glucuronic acid and ...

Claims

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