Let-7 microrna and mimetics thereof as therapeutics for cancer

US20100310583A1Inactive Publication Date: 2010-12-09IMMUNE DISEASE INST INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
IMMUNE DISEASE INST INC
Publication Date
2010-12-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and / or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and / or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.
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Description

CROSS REFERENCED APPLICATIONS

[0001] This Application claims benefit under 35 U.S.C. §119(e) of U.S. Provisional Application Ser. No. 60 / 898,610 filed Jan. 31, 2007, the contents of which is incorporated herein in its entirety by reference.GOVERNMENT SUPPORT

[0002] This invention was made with government support to ES under Contract No. 30525022 awarded by the National Science Foundation of China, Contract No. 2005CB724605 awarded by the 973 Program Project from Ministry of Science and Technology of China.BACKGROUND OF THE INVENTION

[0003] Accumulating evidence suggests that many cancers are maintained in a hierarchical organization of rare, slowly dividing tumor-initiating cells, rapidly dividing amplifying cells (precursor cells) and differentiated tumor cells1,2. Tumor-initiating (also termed cancer stem) cells have been identified in hematologic3-5, brain6-8, breast9,10 prostate11 and colon cancers12. Stem cells, which are self-renewing and can differentiate into heterogeneous cell po...

Claims

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