Medical and Imaging Nanoclusters

Inactive Publication Date: 2013-01-24
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0010]In yet another specific embodiment the present invention discloses a photo-thermolysis method for treating cancer and artherosclerosis by induced cell death comprising the steps of, identifying a patient in need for treatment, administering one or more biodegradable nanocluster compositions to the sample, comprising two or more nanoparticles each comprising one or more metals, metal oxides, inorganic substances, or a combination thereof, and one or more stabilizers in contact with the two or more nanoparticles to form a biodegradable nanocluster composition in w

Problems solved by technology

Gold nanomaterials have intrinsic problems based on the consideration of effectiveness, toxicity and stability discussed on the above.
To synthesis high quality gold nanorods, a

Method used

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  • Medical and Imaging Nanoclusters
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  • Medical and Imaging Nanoclusters

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Embodiment Construction

[0072]While the making and using of various embodiments of the present invention are discussed in detail below, it should be appreciated that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific embodiments discussed herein are merely illustrative of specific ways to make and use the invention and do not delimit the scope of the invention.

[0073]To facilitate the understanding of this invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention. Terms such as “a”, “an” and “the” are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not delimit the invention, except as outlined in the claims.

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Abstract

In one embodiment the present invention discloses a nanocluster or a nanorose composition comprising two or more closely spaced nanoparticles each comprising one or more metals, metal oxides, inorganic substances, or a combination thereof and one or more stabilizers. The stabilizers are in contact with the two or more closely spaced nanoparticles to form a nanocluster composition in which the inorganic weight percentage is greater than 50% and the average size is below 300 nm, and the nanocluster composition has magnetic properties, optical properties or a combination of both.

Description

TECHNICAL FIELD OF THE INVENTION[0001]The present invention relates in general to the field of nanoclusters of metal nanoparticles, particularly gold nanoparticles, composite nanoclusters of metals and metal oxide nanoparticles and more particularly, to compositions, methods, and applications of nanoclusters stabilized by small amounts of polymers including biocompatible or biodegradable polymers.BACKGROUND ART[0002]Without limiting the scope of the invention, its background is described in connection with medical uses for gold or gold-coated nanoparticles where the nanocluster is optimized to have enhanced NIR absorbance. It will be understood that in general, other types of primary nanoparticle, both organic and inorganic, and possibly optimized for other types of electromagnetic interaction are also described by the invention.[0003]Many current efforts include development of targeted gold nanocomposites as contrast agents in near infrared (NIR) region for optical imaging (optical...

Claims

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Application Information

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IPC IPC(8): A61K9/14G01N24/00G01N29/06A61K49/08A61P35/00A61P9/10A61K31/519A61K38/16A61K31/7105A61K39/395A61K31/713A61M37/00A61B6/00A61B5/055A61B8/00G01N21/00B82Y5/00B82Y15/00
CPCA61K9/0009A61K9/5115A61K9/5192A61K49/225A61K49/0002A61K49/0065A61K49/1887A61K41/0052A61P35/00A61P9/10
Inventor JOHNSTON, KEITH P.MA, LI L.FELDMAN, MARC D.MILNER, THOMAS E.SOKOLOV, KONSTANTIN V.ROWE, JASMINETAM, JUSTINAEMELIANOV, STANISLAVTRAVIS, KORTMURTHY, AVINASH K.
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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