Imidazopyridine and Oxazolopyridine Derivatives and Analogs Thereof, Methods of Preparation Thereof, Methods of HIF-2A Pathway Inhibition, and Induction of Ferroptosis

Abstract

Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-2α or iron metabolism.

Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of and priority to U.S. Prov. Pat. App. Ser. No. 62 / 805,699 entitled “Imidazopyridine and oxazolopyridine derivatives and analogs thereof, methods of preparation thereof, methods of HIF-2α pathway inhibition, and induction of ferroptosis,” filed Feb. 14, 2019, the entirety of which is incorporated by reference herein.STATEMENT OF FEDERAL FUNDING

[0002] This invention was in part funded by grants from the National Institutes of Health, National Institute on Drug Abuse 1R03DA033980 and the National Cancer Institute Small Business Innovation Research Program R43CA217385. The government has certain rights in the invention.BACKGROUND1. Technical Field

[0003] The present disclosure relates to novel compounds and more particularly to imidazopyridine and oxazolopyridine derivative and analogs thereof as well as methods of making and using such compounds.2. Related Technology

[0004] Hypoxia provides the required extra...

Images