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Anticalcification Treatment For Impantable Biological Tissues Using Calcitonin

Active Publication Date: 2020-03-05
AGATHOS EFSTATHIOS ANDREAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a treatment method that allows for the formation of harmful substances in biological tissue, which can damage calcium cations in the body. This treatment can be used to improve the patency of arterial grafts, which are more suitable for young patients or those with a longer life expectancy. The technique is also easier and faster to perform, making it the preferred option in emergency situations or for patients with higher operative risk. Overall, the treatment can make arterial grafts more reliable and durable, which is important for surgeons to consider when making a decision on the best graft option for patients.

Problems solved by technology

While some have suggested the use of additional compounds, such as an eNOS activator and / or an anti-proliferative agent, such compounds are not needed and are preferably lacking in the treatment contemplated herein.

Method used

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Embodiment Construction

[0023]The detailed description set forth below is intended as a description of the presently preferred embodiments of the invention, and is not intended to represent the only form in which the present invention may be constructed or utilized. The description sets forth the functions and sequence of steps for certain treatment embodiments of the invention.

[0024]In one embodiment, the method comprises placing the biological tissue for fixation and preservation in a buffered fixative solution (e.g. 0.5% at pH 7.4) and adding calcitonin. Thus, this embodiment involves the use of calcitonin at the time the fixative is used, i.e. together in a mixture. It is not intended that the present invention be limited to any particular source of calcitonin. However, salmon synthetic calcitonin (CT) is a convenient source.

[0025]As a pre-treatment step, the biomaterial can be first treated with a saline solution. For example, after harvesting, the biological tissue is rinsed and maintained in cold sa...

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Abstract

This invention relates to the field of surgical implants, and in particular to a method of treating biomedical material, and more particularly bioprosthetic heart valves and tracheas, to mitigate calcification when implanted in a mammalian body.

Description

FIELD OF INVENTION[0001]This invention relates to the field of surgical implants, and in particular to a method of treating biomedical material, and more particularly bioprosthetic heart valves and tracheas, to mitigate calcification when implanted in a mammalian body.BACKGROUND[0002]Calcification remains the major role of failure of implantable biomedical material and in particular of bioprosthetic valves. Bioprosthetic heart valves may be constructed either from porcine aortic valves, or bovine pericardium (W. R. E. Jameison: J. Cardiac Surgery., 1993;8;89-98). New animals have been tested such as Kangaroo (C. Weinhold et al., Z. Kardiol. 75, Suppl. 2,pp 251-253, 1986), seal aortic and pulmonary valves as well as pericardium (U.S. Pat. No 6,165,216, Agathos E. A.: Human Cardiac Valve Placement with Marine Mammal Ventricular Outflow (Aortic or Pulmonary) Valve) and Equine pericardium (Xavier M. Mueller, Ludwig K. von Segesser: A new equine pericardial stentless valve J Thorac Cardi...

Claims

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Application Information

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IPC IPC(8): A61L27/36
CPCA61L27/3612A61L27/3625A61L2430/06A61L2400/02A61L27/3654A61L27/3687A61L27/367A61L2430/20A61L27/3641A61L27/507A61L2300/252A61L2300/43A61L2430/40A61F2/2412
Inventor AGATHOS, EFSTATHIOS-ANDREAS
Owner AGATHOS EFSTATHIOS ANDREAS
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