84 results about "Marine mammal" patented technology

Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and / or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.

This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome.

The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.

A system for passive acoustic monitoring in connection with seismic surveying includes a survey vessel having a recording system thereon. At least one seismic energy source is coupled to the vessel by a first towing cable. The towing cable includes at least one conductor therein. At least one seismic sensor streamer is coupled to the vessel by a lead in cable. At least one acoustic sensor is coupled to the at least one source by a second towing cable. The second towing cable includes at least one signal conductor configured to transmit signals from the acoustic sensor to the at least one conductor in the first towing cable. The at least one acoustic sensor is configured to detect marine mammal vocalization.

A method for localizing a marine animal in an underwater environment implemented by a passive acoustic monitoring (PAM) system. The passive acoustic monitoring system includes network of acoustic sensors adapted to carry out measurements of acoustic signals. The method includes: obtaining, from the network of acoustic sensors, measured data of an acoustic signal emitted by a marine animal; defining a space of dimensional representation of the underwater environment discretized in a plurality of predefined cells, for each cell of a predefined set, obtaining an error defined as a value of a cost function for the cell, the cost function giving a deviation between: at least some of the measured data; and corresponding theoretical data obtained by assuming the marine animal is located in the cell, the errors obtained for the predefined set of cells enabling to obtain at least one piece of information about localization of the marine animal.

This invention provides a system apparatus and method for ship-towed deployment of a non-linear volumetric array of hydrophones, allowing line-intersect or line-transect sampling of marine mammal populations through passive acoustic monitoring, enabling unambiguous real-time three-dimensional localization of single sounds received through a low-cost, modular, robust, stable, small, light, neutrally to slightly negatively buoyant volumetric array having low self-noise and low flow noise, that avoids putting high tension on the tow cable and that is compatible with standard hydrophones, instrumentation, cabling, and analytical software.

An energy-harvesting compute grid includes computing assemblies that cooperate with mobile energy harvesters configured to be deployed on a body of water. The plurality of energy harvesters are positioned on and move adjacent to an upper surface of a body of water, and the locations of the energy harvesters can be monitored and controlled. The wide-spread gathering by the harvesters of environmental data within that geospatial area permits the forecasting of environmental factors, the discovery of advantageous energy-harvesting opportunities, the observation and tracking of hazardous objects and conditions, the efficient distribution of data and / or tasks to and between the harvesters included in the compute grid, the efficient execution of logistical operations to support, upgrade, maintain, and repair the cluster, and the opportunity to execute data-gathering across an area much larger than that afforded by an individual harvester (e.g., radio astronomy, 3D tracking of and recording of the communication patterns of marine mammals, etc.). The computational tasks can be shared and distributed among a compute grid implemented in part by a collection of individual floating self-propelled energy harvesters thereby providing many benefits related to cost and efficiency that are unavailable to relatively isolated energy harvesters, and likewise unavailable to terrestrial compute grids of the prior art.

The present invention is directed to a method of assessing in vivo human glial cell response to pathogenic infection that involves providing a non-human mammal either with at least 30% of its glial cells in its corpus callosum being human glial cells and / or with at least 5% of its glial cells its brain and brain stem white matter being human glial cells, subjecting the non-human mammal to pathogenic infection and assessing the in vivo human glial cell response to pathogenic infection. A method of identifying therapeutic agents for the pathogenic infection as well as forms of the non-human mammal having a pathogenic brain infection are also disclosed.

The invention discloses a medicinal injection for killing coral predator acanthaster planci. The medicinal injection for killing the coral predator acanthaster planci contains Vibrio alginolyticus, Vibrio parahaemolyticus and a culture medium. The Vibrio alginolyticus HN492 and the Vibrio parahaemolyticus A16 in the medicinal injection for killing the acanthaster planci are separated from a seawater environment, are harmless to the environment under conventional concentrations, do not belong to pathogenic strains, and do not have pathogenicity for marine animals of marine fishes, shrimps, acanthaster planci and the like. According to the mechanism of the medicinal injection of killing the acanthaster planci, the bacteria form ultrahigh concentrations in acanthaster planci bodies locally, various enzymes and metabolites which are secreted by the bacteria cause damage to tissues in the acanthaster planci bodies, and a large amount of bacterial protein causes stress for the acanthaster planci, and causes death at last.

The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.

This invention provides a system apparatus and method for ship-towed deployment of a non-linear volumetric array of hydrophones, allowing line-intersect or line-transect sampling of marine mammal populations through passive acoustic monitoring, enabling unambiguous real-time three-dimensional localization of single sounds received through a low-cost, modular, robust, stable, small, light, neutrally to slightly negatively buoyant volumetric array having low self-noise and low flow noise, that avoids putting high tension on the tow cable and that is compatible with standard hydrophones, instrumentation, cabling, and analytical software.

Low probability of marine mammal impact (LPMMI) sound signals have a modulation component selected to reduce a behavioral response from a marine mammal from that which would occur when transmitting another sound signal having approximately the same time duration component, approximately the same bandwidth component, and approximately the same center frequency component as the LPMMI waveform but having a modulation component comprising a frequency modulation.

The present invention discloses methods for cell nuclear transfer that comprise for example modification of zona pellucida of an oocyte, and / or sectioning of oocytes into several parts. The present invention also discloses methods for producing a genetically modified non-human mammal. Genetically modified non-human mammals obtainable by the disclosed methods are also within the scope of the present invention. Disclosed are also methods for cryopreservation of cells.