Treatment or prevention of anaemia in pregnant non-human mammals

Abstract

The present invention relates to an iron carbohydrate complex for use in a method of increasing the blood haemoglobin concentration in a pregnant non-human mammal, wherein the pregnant non-human mammal having a blood haemoglobin level of 105 g / L or less, is administered one or more doses of iron carbohydrate complex comprising an amount of elemental iron of 1800 mg or more per dose. The method relates to the further effects of decreasing the rate of stillborn offsprings from a pregnant non-human mammal having a blood haemoglobin level of 105 g / L or less, increasing the blood haemoglobin concentration of offspring litters within 3 days from birth and / or weaning, or increasing the litter size in a subsequent parity of a non-human mammal having a blood haemoglobin level of 105 g / L or less.

Description

FIELD OF THE INVENTION[0001]The present invention relates to the treatment of anaemia in pregnant non-human mammals with iron carbohydrate complexes. The invention generally improves the haemoglobin level of the non-human mammal and / or parameters, which are measured on offspring, such as the stillborn rate, the mortality rate in the suckling period, the increase in the haemoglobin level, and the growth rate in the suckling period.PRIOR ART[0002]Several studies suggest that anaemia is highly prevalent in sows although rarely diagnosed in veterinary practice. A recent Danish investigation demonstrated that 59% of sows in a large commercial Danish herd had blood haemoglobin (Hb) concentrations below 110 g / l (Jensen et al, 2014), which is considered as a lower limit reference value for pregnant sows (Thorn, 2010).[0003]The most common reason for anaemia is iron deficiency. As iron is involved in the transport of oxygen, in the synthesis of DNA and in many other processes maintaining nor...

AI Technical Summary

Benefits of technology

The iron carbohydrate complex effectively increases maternal and offspring haemoglobin levels, decreases stillbirth rates, and improves offspring survival and growth, potentially eliminating the need for additional iron supplementation in piglets, thereby addressing the economic and welfare issues in pig production.

Problems solved by technology

In Denmark stillbirth losses average 1.7 piglets per litter (Vinther, 2013) and thereby impose a serious economic and welfare issue in pig production.

Herd interventions in order to reduce number of stillbirths are often difficult to apply and can only rarely be contributed to infectious or management factors.