Methods for inhibiting tumor cell proliferation

Abstract

The present invention provides methods, compounds, and pharmaceutical compositions for inhibiting tumor cell proliferation, by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT₂ type 2 receptor agonists to a subject.

Description

CROSS REFERENCE[0001]This application claims priority to U.S. Provisional Patent Application Ser. No. 60 / 287,760 filed May 1, 2001.FIELD OF THE INVENTION[0002]This present invention relates to compositions and methods useful for the inhibition of tumor cell proliferation.BACKGROUND OF THE INVENTION[0003]Despite many years of promising new therapies, cancer remains a major cause of morbidity and mortality (Bailar et al., N. Engl. J. Med. 336:1569–1574, 1997). Typical therapeutic treatments may include surgery, radiation therapy, and / or chemotherapy. A variety of chemotherapeutic compounds have found widespread use in the clinical treatment of cancer and have proven to be indispensable in the effort to combat this disease. Nevertheless, on an individual case basis, some cancers can respond differently to a given therapy making it difficult and costly to achieve an effective clinical treatment regimen. Accordingly, there is a substantial need for new methods and active agents that are ...

AI Technical Summary

Benefits of technology

[0004]The present invention provides methods for inhibiting tumor cell proliferation by administering to a patient in need thereof an amount effective of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists, either alone, combined, or in further combination with known therapeutic methods for inhibiting tumor cell proliferation, such as surgery, cytokine therapy, hormone therapy, and anti-hormone therapy. In a preferred embodiment, the tumor comprises an adenocarcinoma. In a further preferred embodiment, the tumor comprises an adenocarcinoma of ovarian, endometrial, uterine, or breast origin.

Problems solved by technology

Despite many years of promising new therapies, cancer remains a major cause of morbidity and mortality (Bailar et al., N. Engl. J. Med. 336:1569–1574, 1997).

Nevertheless, on an individual case basis, some cancers can respond differently to a given therapy making it difficult and costly to achieve an effective clinical treatment regimen.