Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food

Abstract

The invention relates to application of an integripetal rhodiola herb and ginkgo leaf composition to the preparation of anti-hypoxia medicaments or health-care food. The composition consists of an integripetal rhodiola herb extract and a ginkgo leaf extract in a weight ratio of (2-10):1. By adopting the ratio, the integripetal rhodiola herb and ginkgo leaf composition is superior to the prior art in an anti-hypoxia aspect.

Description

technical field

[0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the application of rhodiola rosea and ginkgo biloba composition in the preparation of hypoxia-resistant medicine or health food. Background technique

[0002] Hypoxia is a pathological process shared by many clinical diseases, and it is an important cause of death caused by many diseases. Oxygen in the atmosphere enters the alveoli through breathing, diffuses into the blood, combines with hemoglobin, is transported by the blood circulation to the whole body, and is finally taken up and utilized by tissues and cells. An obstacle in any of these links can cause hypoxia. When tissues and cells do not receive sufficient oxygen or cannot make full use of oxygen, the pathological process of abnormal changes in the metabolism, function and morphological structure of tissues and cells is called hypoxia.

[0003] Hypoxia can be divided into four types: hypoxic hypox...

Examples

Embodiment 1

[0039] Example 1: Tablets of Rhodiola Rosea Extract and Ginkgo Leaf Extract (2.25:1)

[0040] 1. Raw materials: Rhodiola rosea extract 112.5g, ginkgo leaf extract 50g, microcrystalline cellulose 235.5g, 20% starch slurry 48g, magnesium stearate 2g.

[0041] 2. Preparation method: Weigh rhodiola rosea extract, ginkgo leaf extract, and microcrystalline cellulose that have been crushed through a 80-mesh sieve, mix for 30 minutes, add starch slurry, stir for 20 minutes, granulate with a 18-mesh nylon sieve, and heat at 55°C Dry it under the sun for 30 minutes, detect that the moisture is 4.0%, granulate with a 18-mesh nylon sieve, add magnesium stearate, mix for 20 minutes, compress into tablets (0.4g / tablet), and get final product.

[0042] 3. Tablet detection: Check the tablet disintegration time according to the Chinese Pharmacopoeia 2010 edition, Appendix XII A disintegration time limit inspection method, and check the tablet brittleness according to the Chinese Pharmacopoeia ...

Embodiment 2

[0044] Example 2: Tablets of Rhodiola Rosea Extract and Ginkgo Leaf Extract (2:1)

[0045] 1. Raw materials: Rhodiola rosea extract 170g, ginkgo leaf extract 85g, microcrystalline cellulose 110g, starch 210g, hydroxymethyl starch 40g, 25% starch slurry 85g, magnesium stearate 4g.

[0046] 2. Preparation method:

[0047] Weigh the Rhodiola rosea extract, ginkgo leaf extract, microcrystalline cellulose, starch, and hydroxymethyl starch that have been crushed through a 80-mesh sieve, mix for 20 minutes, add 25% starch slurry, stir for 10 minutes, and pass through a 18-mesh sieve to prepare Granules, dried at 60°C for 40 minutes, tested to be 4.3% moisture, passed through a 18-mesh sieve for granulation, added magnesium stearate, mixed for 30 minutes, compressed into tablets (0.4g / tablet), and obtained.

[0048] 3, detection: detection method with reference to embodiment 1, result:

[0049] The obtained tablet has a smooth surface, strong compressibility, good hardness, a disinteg...

Embodiment 3

[0050] Example 3: Tablets of Rhodiola Rosea Extract and Ginkgo Leaf Extract (3:1)

[0051] 1. Raw materials: Rhodiola rosea extract 360g, ginkgo biloba extract 120g, microcrystalline cellulose 485g, starch 200g, 15% starch slurry 155g, magnesium stearate 6g

[0052] 2. Preparation method:

[0053] Weigh the Rhodiola rosea extract, ginkgo leaf extract, microcrystalline cellulose, and starch that have been crushed through a 80-mesh sieve, mix for 40 minutes, add 15% starch slurry, stir for 15 minutes, pass through a 18-mesh sieve for granulation, and granulate at 50°C Dry for 60 minutes, detect that the water content is 3.8%, pass through a 18-mesh sieve for granulation, add magnesium stearate, mix for 40 minutes, and compress into tablets (0.4g / tablet).

[0054] 3, detection: detection method is with embodiment 1, and the result is:

[0055] The obtained tablet has a smooth surface, strong compressibility, good hardness, a disintegration time of 18 minutes, and a friability o...

technical field

[0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the application of rhodiola rosea and ginkgo biloba composition in the preparation of hypoxia-resistant medicine or health food. Background technique

[0002] Hypoxia is a pathological process shared by many clinical diseases, and it is an important cause of death caused by many diseases. Oxygen in the atmosphere enters the alveoli through breathing, diffuses into the blood, combines with hemoglobin, is transported by the blood circulation to the whole body, and is finally taken up and utilized by tissues and cells. An obstacle in any of these links can cause hypoxia. When tissues and cells do not receive sufficient oxygen or cannot make full use of oxygen, the pathological process of abnormal changes in the metabolism, function and morphological structure of tissues and cells is called hypoxia.

[0003] Hypoxia can be divided into four types: hypoxic hypox...

Examples

Embodiment 1

[0039] Example 1: Tablets of Rhodiola Rosea Extract and Ginkgo Leaf Extract (2.25:1)

[0040] 1. Raw materials: Rhodiola rosea extract 112.5g, ginkgo leaf extract 50g, microcrystalline cellulose 235.5g, 20% starch slurry 48g, magnesium stearate 2g.

[0041] 2. Preparation method: Weigh rhodiola rosea extract, ginkgo leaf extract, and microcrystalline cellulose that have been crushed through a 80-mesh sieve, mix for 30 minutes, add starch slurry, stir for 20 minutes, granulate with a 18-mesh nylon sieve, and heat at 55°C Dry it under the sun for 30 minutes, detect that the moisture is 4.0%, granulate with a 18-mesh nylon sieve, add magnesium stearate, mix for 20 minutes, compress into tablets (0.4g / tablet), and get final product.

[0042] 3. Tablet detection: Check the tablet disintegration time according to the Chinese Pharmacopoeia 2010 edition, Appendix XII A disintegration time limit inspection method, and check the tablet brittleness according to the Chinese Pharmacopoeia ...

Embodiment 2

[0044] Example 2: Tablets of Rhodiola Rosea Extract and Ginkgo Leaf Extract (2:1)

[0045] 1. Raw materials: Rhodiola rosea extract 170g, ginkgo leaf extract 85g, microcrystalline cellulose 110g, starch 210g, hydroxymethyl starch 40g, 25% starch slurry 85g, magnesium stearate 4g.

[0046] 2. Preparation method:

[0047] Weigh the Rhodiola rosea extract, ginkgo leaf extract, microcrystalline cellulose, starch, and hydroxymethyl starch that have been crushed through a 80-mesh sieve, mix for 20 minutes, add 25% starch slurry, stir for 10 minutes, and pass through a 18-mesh sieve to prepare Granules, dried at 60°C for 40 minutes, tested to be 4.3% moisture, passed through a 18-mesh sieve for granulation, added magnesium stearate, mixed for 30 minutes, compressed into tablets (0.4g / tablet), and obtained.

[0048] 3, detection: detection method with reference to embodiment 1, result:

[0049] The obtained tablet has a smooth surface, strong compressibility, good hardness, a disinteg...

Embodiment 3

[0050] Example 3: Tablets of Rhodiola Rosea Extract and Ginkgo Leaf Extract (3:1)

[0051] 1. Raw materials: Rhodiola rosea extract 360g, ginkgo biloba extract 120g, microcrystalline cellulose 485g, starch 200g, 15% starch slurry 155g, magnesium stearate 6g

[0052] 2. Preparation method:

[0053] Weigh the Rhodiola rosea extract, ginkgo leaf extract, microcrystalline cellulose, and starch that have been crushed through a 80-mesh sieve, mix for 40 minutes, add 15% starch slurry, stir for 15 minutes, pass through a 18-mesh sieve for granulation, and granulate at 50°C Dry for 60 minutes, detect that the water content is 3.8%, pass through a 18-mesh sieve for granulation, add magnesium stearate, mix for 40 minutes, and compress into tablets (0.4g / tablet).

[0054] 3, detection: detection method is with embodiment 1, and the result is:

[0055] The obtained tablet has a smooth surface, strong compressibility, good hardness, a disintegration time of 18 minutes, and a friability o...

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