Emulsifiable paste with inflammation diminishing, itching relieving and antibacterial effects and preparation method thereof

Abstract

The invention relates to emulsifiable paste with inflammation diminishing, itching relieving and antibacterial effects and a preparation method thereof. The emulsifiable paste with the inflammation diminishing, itching relieving and antibacterial effects is prepared from the following components in parts by weight: 1.0 to 5.0 percent of menthol, 5.0 to 10.0 percent of camphor, 1.0 to 5.0 percent of methyl salicylate, 0.5 to 1.0 percent of borneol, 0.1 to 0.5 percent of thymol crystals, 0.01 to 0.05 percent of beclomethasone, 6.0 to 10.0 percent of an emulsifier Gelot 64, 3.0 to 6.0 percent ofoctadecanol, 4.0 to 7.0 percent of monoglyceride and the balance of purified water. The emulsifiable paste of the formula is low in irritation to the skin, is not oily and has the characteristics of easiness in cleaning, high stability of effective components and relatively long preservation time; according to the manufacturing method disclosed by the invention, a homogenous phase body is formed by the emulsifier Gelot 64, the octadecanol, the monoglyceride and the water, so that the process is simplified; the emulsifiable paste further has the advantages of higher stability of the effective components and longer validity period.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a cream with anti-inflammatory, anti-itch and anti-bacterial effects and a preparation method thereof. Background technique

[0002] The skin covers the surface of the human body and is the largest organ in the human body. For a long time, skin diseases have brought great troubles to people's daily production. Promise cream is the common name of compound beclomethasone camphor cream, which has anti-inflammatory, analgesic, antipruritic, antibacterial, local anesthetic effects, etc. It is effective for insect bite dermatitis, papular urticaria, eczema, contact dermatitis, neurodermatitis, skin It has a good therapeutic effect on various skin discomforts such as itching.

[0003] In the prior art, there are many formulations of Wuji paste, and the preparation process is relatively complicated. Since the oil phase components and the water phase components are not well compatible, ...

Examples

Embodiment 1

[0040] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0041] 1) Take each raw material according to the dosage in Table 1;

[0042] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 80°C, and add it to the purified water previously heated to 80°C under stirring conditions to obtain the mixture A;

[0043] 3) Cool the mixture A to 58°C, add menthol, camphor, borneol, and thymol, and continue stirring to obtain paste B;

[0044] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0045] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

[0046] Table 1 raw material consumption table (weight parts)

[0047]

[0048]

Embodiment 2

[0050] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0051] 1) Take each raw material according to the dosage in Table 1;

[0052] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 85°C, and add it to the purified water previously heated to 85°C under stirring conditions to obtain the mixture A;

[0053] 3) Cool mixture A to 55°C, add menthol, camphor, borneol, thymol, and continue stirring to obtain paste B;

[0054] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0055] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

Embodiment 3

[0057] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0058] 1) Take each raw material according to the dosage in Table 1;

[0059] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 75°C, and add it to the purified water previously heated to 75°C under stirring conditions to obtain mixture A;

[0060] 3) Cool the mixture A to 56°C, add menthol, camphor, borneol, and thymol, and continue stirring to obtain paste B;

[0061] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0062] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

technical field

[0001] The invention relates to the technical field of medicine, in particular to a cream with anti-inflammatory, anti-itch and anti-bacterial effects and a preparation method thereof. Background technique

[0002] The skin covers the surface of the human body and is the largest organ in the human body. For a long time, skin diseases have brought great troubles to people's daily production. Promise cream is the common name of compound beclomethasone camphor cream, which has anti-inflammatory, analgesic, antipruritic, antibacterial, local anesthetic effects, etc. It is effective for insect bite dermatitis, papular urticaria, eczema, contact dermatitis, neurodermatitis, skin It has a good therapeutic effect on various skin discomforts such as itching.

[0003] In the prior art, there are many formulations of Wuji paste, and the preparation process is relatively complicated. Since the oil phase components and the water phase components are not well compatible, ...

Examples

Embodiment 1

[0040] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0041] 1) Take each raw material according to the dosage in Table 1;

[0042] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 80°C, and add it to the purified water previously heated to 80°C under stirring conditions to obtain the mixture A;

[0043] 3) Cool the mixture A to 58°C, add menthol, camphor, borneol, and thymol, and continue stirring to obtain paste B;

[0044] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0045] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

[0046] Table 1 raw material consumption table (weight parts)

[0047]

[0048]

Embodiment 2

[0050] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0051] 1) Take each raw material according to the dosage in Table 1;

[0052] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 85°C, and add it to the purified water previously heated to 85°C under stirring conditions to obtain the mixture A;

[0053] 3) Cool mixture A to 55°C, add menthol, camphor, borneol, thymol, and continue stirring to obtain paste B;

[0054] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0055] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

Embodiment 3

[0057] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0058] 1) Take each raw material according to the dosage in Table 1;

[0059] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 75°C, and add it to the purified water previously heated to 75°C under stirring conditions to obtain mixture A;

[0060] 3) Cool the mixture A to 56°C, add menthol, camphor, borneol, and thymol, and continue stirring to obtain paste B;

[0061] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0062] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

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