A method for the preparation of fe 3 o 4 Fluid synthesis preparation device and control method for magnetic nanoparticles

Abstract

The invention relates to a method for preparing Fe 3 o 4 The fluid synthesis and preparation device of magnetic nanoparticles and its control method, compared with the prior art, solves the problem that has not been able to prepare Fe 3 o 4 Drawbacks of Magnetic Nanoparticle Devices. The present invention includes a first micro-reaction chamber assembly and a second micro-reaction chamber assembly, the first micro-reaction chamber assembly includes a first micro-reaction chamber, an ethylene glycol supply pipe is connected to the upper end of the first micro-reaction chamber, and the first The bottom of the micro-reaction chamber is funnel-shaped. The first micro-reaction chamber is placed on a magnetic stirrer. There is a sieve plate in the first micro-reaction chamber. Magnets are placed on the sieve plate. The head end of the silicone tube is connected to the first micro-reaction chamber. At the bottom of the first micro-reaction chamber, the end of the silicone tube is connected to the upper end of the second micro-reaction chamber assembly. The present invention provides the ability to synthesize Fe 3 o 4 The preparation device of magnetic nanoparticles, combined with the fluid control method based on the pump valve, can realize Fe 3 o 4 Automated preparation of magnetic nanoparticles.

Description

technical field

[0001] The invention relates to the technical field of chemical preparation devices, in particular to a method for preparing Fe 3 o 4 A fluid synthesis preparation device for magnetic nanoparticles and a control method thereof. Background technique

[0002] Fe 3 o 4 Magnetic nanoparticles are a common superparamagnetic nanomaterial, which has the characteristics of magnetic conductivity and nanomaterials, and also has the advantages of simple preparation, low toxicity, and good biocompatibility, so it is widely used in clinical diagnosis, Contrast imaging, targeted drugs, biomarkers and separations, etc.

[0003] In order to obtain monodisperse, uniformly sized Fe 3 o 4 Nanoparticles, generally adopt the hydrothermal method, that is: add trisodium citrate, anhydrous sodium acetate and other reagents in turn to ferric chloride dissolved in ethylene glycol, stir for half an hour to fully dissolve them; Transfer to a reaction kettle, place in an oven at 2...

Examples

Embodiment Construction

[0034] In order to have a further understanding and understanding of the structural features of the present invention and the achieved effects, the preferred embodiments and accompanying drawings are used for a detailed description, as follows:

[0035] In order to match the Fe 3 o 4 Implementation of chemical preparation methods (control methods) for magnetic nanoparticles, such as figure 1 Shown, the present invention comprises the first micro-reaction chamber assembly and the second micro-reaction chamber assembly, and the first micro-reaction chamber assembly comprises the first micro-reaction chamber 1, and the first micro-reaction chamber 1 is used for simulating Fe 3 o 4 Addition of reagents and magnetic stirring dissolution process in the preparation process of magnetic nanoparticles.

[0036] The upper end of the first micro-reaction chamber 1 is connected with an ethylene glycol supply pipe 2, and a first peristaltic pump 14 and a first pinch valve 15 can be inst...

technical field

[0001] The invention relates to the technical field of chemical preparation devices, in particular to a method for preparing Fe 3 o 4 A fluid synthesis preparation device for magnetic nanoparticles and a control method thereof. Background technique

[0002] Fe 3 o 4 Magnetic nanoparticles are a common superparamagnetic nanomaterial, which has the characteristics of magnetic conductivity and nanomaterials, and also has the advantages of simple preparation, low toxicity, and good biocompatibility, so it is widely used in clinical diagnosis, Contrast imaging, targeted drugs, biomarkers and separations, etc.

[0003] In order to obtain monodisperse, uniformly sized Fe 3 o 4 Nanoparticles, generally adopt the hydrothermal method, that is: add trisodium citrate, anhydrous sodium acetate and other reagents in turn to ferric chloride dissolved in ethylene glycol, stir for half an hour to fully dissolve them; Transfer to a reaction kettle, place in an oven at 2...

Examples

Embodiment Construction

[0034] In order to have a further understanding and understanding of the structural features of the present invention and the achieved effects, the preferred embodiments and accompanying drawings are used for a detailed description, as follows:

[0035] In order to match the Fe 3 o 4 Implementation of chemical preparation methods (control methods) for magnetic nanoparticles, such as figure 1 Shown, the present invention comprises the first micro-reaction chamber assembly and the second micro-reaction chamber assembly, and the first micro-reaction chamber assembly comprises the first micro-reaction chamber 1, and the first micro-reaction chamber 1 is used for simulating Fe 3 o 4 Addition of reagents and magnetic stirring dissolution process in the preparation process of magnetic nanoparticles.

[0036] The upper end of the first micro-reaction chamber 1 is connected with an ethylene glycol supply pipe 2, and a first peristaltic pump 14 and a first pinch valve 15 can be inst...

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