The invention relates to the technical field of bed textile articles, and particularly relates to a pillow towel fabric with nerve-soothing and sleeping-aiding effects. The pillow towel fabric is prepared from bamboo fiber, linen fiber, aloe fiber, silk fiber and sleeping-aiding modified polyester fiber; both sides of the pillow towel fabric are coated provided with sleeping-aiding medicine liquid layers; the sleeping-aiding modified polyester fiber is prepared from polyethylene glycol terephthalate master batch, poly-p-phenylene terephthamide master batch, nanometer titanium dioxide, perlite powder, amethyst powder, far-infrared ceramic powder, plant sleeping-aiding extracting powder, vinyl silane coupling agent, and viscosity fiber. The pillow towel fabric has the advantages that by adopting the air-ventilating soft raw material fiber, the comfortable sleeping experience is provided; by adopting the sleeping-aiding modified polyester fiber, the functions of relieving disturbance and promoting deep sleeping are realized, and the nerve-soothing and sleeping-aiding effects of the pillow towel fabric are enhanced; by adopting the sleeping-aiding medicine liquid layer, the effect is quick; in combination with the sleeping-aiding modified polyester fiber and other raw material fiber, the pillow towel fabric can soothe nerves and nourish heart, and be helpful for good sleeping.