30 results about "Early stage disease" patented technology

The present invention provides smell tests (odor identification tests) that are shorter that UPSIT, yet has a statistical sensitivity and specificity equivalent to or better than UPSIT. The odor identification tests of the invention are based on a core set of six odorants, where the six odorants can be selected from the following group of odorants: menthol, clove, leather, strawberry, lilac, pineapple, smoke, soap, natural gas and lemon. The present invention provides odor identification tests that can: (1) discriminate between subjects who are normal and who have a neuropsychiatric condition, cognitive disease or disorder, and / or (2) predict which subjects with mild cognitive disorders will develop various neuropsychiatric conditions or cognitive diseases and disorders. In one embodiment, the test and methods of the invention can provide an early prediction or diagnosis of Alzheimer's disease that is important for patients (including patients who have mild cognitive disorders, such as MCI) and clinicians to make plans for the future and to institute early treatment.

The invention relates to the technical field of medical equipment, and discloses a focus image recognition method and a focus image recognition system based on a deep learning model. The invention provides a new method and a new system for automatically identifying conditions of medical images by replacing doctors based on the deep learning model. Regarding acquired to-be-detected medical images,Segmentation of a smallest organ tissue image and image recognition of a corresponding organ tissue, prediction of a deep learning model and marking on a predication result are carried out. The invention can replace doctors find out underlying conditions of medical images and automatically mark lesion tissues on the medical images. Therefore, a reminder is given to doctors for timely diagnosis. Working intensity of the doctors can be reduced. Whether diseases occur or not can be timely diagnosed. The treatment opportunity of conditions is prevented from being delayed, and the discovery of early-stage diseases is particularly facilitated.

The invention discloses an in-vivo nondestructive testing system for plant diseases based on an optical imaging technique. Most detection manners for plant diseases aim at disease-visible plant diseases at presents. According to the system, light signals emitted by a light source respectively enter a sample arm and a reference arm after passing through an optical fiber coupler; returned to-be-tested signal light and reference light are intervened at the optical fiber coupler; reference light signals are received by an OCT spectrograph and are input into a control computer; light emitted from axenon lamp is filtered by a narrow-band pass filter to form ultraviolet light, and the ultraviolet light is reflected into an objective lens through a dichroscope and is emitted into a to-be-tested object through an objective lens so as to emit fluorescence; the fluorescence is backtracked to a hyperspectral spectrograph to form a spectrum, and the spectrum is transmitted to a control computer; and then the control computer executes OCT structural image reconstruction on the to-be-tested object, calculates a light penetration depth, an attenuation coefficient and an image entropy, executes spectral information analysis based on a fluorescent hyperspectral image and extracts spectral characteristics. The in-vivo nondestructive testing system can meet the requirements on plant minimal lesion detection, and early-stage disease detection can be realized.

The invention discloses a fluorescence liquid drop sorting system based on digital microfluidics and a sorting method thereof. The fluorescence liquid drop sorting system comprises a digital microfluidic chip, an integrated circuit and a fluorescence excitation and acquisition module. The digital microfluidic chip is connected with the integrated circuit; and the fluorescence excitation and acquisition module is connected with the digital microfluidic chip and the integrated circuit respectively. According to the fluorescence liquid drop sorting system based on the digital microfluidics, disclosed by the invention, generation, transportation and sorting processes of liquid drops are carried out based on an on-chip dielectric wetting principle, so that a realization mechanism of the third party does not need to be added and the miniaturization of the system is relatively easy to realize; and single liquid drops are manipulated and analyzed in the processes, and a biochemical staining and fluorescence protein marking technology is combined, so that the fluorescence liquid drop sorting system can be used for detecting and sorting single cells, secreted proteins or microorganisms, and is used for the fields of early-stage disease diagnosis and treatment and the like.

The invention relates to the technical field of road traffic engineering construction, in particular to an overlapping construction method of a new asphalt pavement and an old asphalt pavement. The method comprises the following steps that the edges of overlapping of the new pavement and the old pavement are milled to be of a step-shaped structure, and the milling surface is cleaned; after a base layer of the new pavement is laid, modified hot asphalt is sprayed on the milling surface; a polyester fiberglass cloth is laid on the upper portion of a joint of the top surface of an old pavement base layer and the top surface of the old pavement base layer; and after a surface layer of the new pavement is laid, crack-resistant paste is laid on the upper portion of a joint of a surface layer of the old pavement and the surface layer of the old pavement. Meanwhile, the invention further discloses an overlapping structure of the new asphalt pavement and the old asphalt pavement. Operation is easy, occurrence of early-stage diseases on the asphalt pavements in the operation stage can be effectively reduced, the service lives of the pavements are prolonged, and saving of the curing cost is facilitated.

The invention discloses a method for identifying early-stage disease spots of sclerotinia sclerotiorum and botrytis of rape. The method comprises steps as follows: (1), a high-spectrum image of a to-be-detected leaf of the rape is taken, and the pixel of a local disease spot of the high-spectrum image is picked; (2), a band ratio operation value and a band differential operation value of the pixel at the band of 681.95 nm-748.23 nm are calculated and obtained; (3), a feature vector composed of a spectrum value of the pixel at the band of 555.29 nm, the band ratio operation value and the band differential operation value is input into a trained least square support vector machine model, and the type of the disease spot is judged according to an output result. A band with a characteristic difference is obtained from the high-spectrum image information with the early-stage disease spots of sclerotinia sclerotiorum and botrytis through analysis, the early-stage disease spots of sclerotinia sclerotiorum and botrytis are accurately classified by combination of a characteristic wavelength, the band ratio operation value, the band differential operation value and a least square support vector machine, and the identification accuracy is higher.

We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.

The invention discloses a monoclonal antibody for resisting to cyprinus carpio haematopterus IgM, a hybridoma cell strain and application of the monoclonal antibody. The monoclonal antibody for resisting to cyprinus carpio haematopterus IgM is secreted and produced by the hybridoma cell strain A5-E10 with the preservation number being CCTCC NO: C2015218. The monoclonal antibody can be applied to detection of certain pathogeny of cyprinus carpio haematopterus or common carp or a vaccine specific antibody of an aquatic product, thereby early-stage disease diagnosis and vaccine using effect evaluation are conducted, high clinical application and promotion value is achieved for epidemiological investigation and pathogeny diagnosis conducted on disease of cyprinus carpio haematopterus or common carp, and reference is provided for prevention and treatment of other cultured fish diseases.

The invention provides a rapid mixed asphalt material gradation detection method and equipment thereof. The rapid mixed asphalt material gradation detection method is characterized by comprising the following steps: (1) sampling a mixed asphalt material; (2) putting a mixed asphalt material sample into a hopper, and subsequently opening the hopper to drop off the mixed asphalt material sample into an inner disc below the hopper; (3) after the inner disc is fully piled, dropping off the mixed asphalt material sample into an outer disc; (4) weighing the mixed asphalt material sample in the outer disc, and calculating rough gradation ratio indexes CMc and CMF and gradation stable coefficient fai, thereby judging whether the gradation of the mixed asphalt material is qualified or not; the rapid mixed asphalt material gradation detection equipment comprises the hopper, a speed control hammer, a mounting rack, a bracket, the outer disc, the inner disc and a base. The method provided by the invention is simple and convenient in detection, the gradation of the mixed asphalt material can be judged by calculating the rough gradation ratio indexes CMc and CMF and gradation stable coefficient fai, on-site detection can be performed rapidly in real time, early-stage diseases of an asphalt pavement can be prevented, and very large social and economic benefits can be achieved.

The invention relates to ultraviolet-ageing-resistant SBR (styrene butadiene rubber) modified asphalt and a preparation method thereof. The ultraviolet-ageing-resistant SBR modified asphalt is characterized by being prepared by mixing he following components in percentage by mass: 7-30% of ultraviolet blocking modifier particles and 70-93% of matrix asphalt, wherein the ultraviolet blocking modifier particles are prepared by kneading and mixing the following materials in percentage by mass: 25%-45% of an SBR modifier, 20%-60% of magnesium-aluminum laminated dual-hydroxide ultraviolet blocking materials, 12%-18% of a compatilizer and 25%-35% of reclaimed rubber by virtue of banburying and mixing equipment. The modified asphalt prepared by the preparation method disclosed by the invention not only can be resistant to the high temperature in summer and low-temperature cold in winter, but also can be used for achieving good effects of physical reflecting, shielding and chemical absorbing for ultraviolet rays in the plateau section, reducing the early-stage diseases of the road surface and greatly prolonging the service life of the asphalt road surface, and can be applied to high-level road construction in the plateau section.

The invention discloses a biomarker miR-216a and target genes Smad3 and Smad7 relating to vascular endothelial senescence and inflammatory reaction, coronary atherosclerosis of the aged and atherosclerotic plaque stability, and verifies up-regulated expression of the miR-216a in a tissue or blood sample of a patient with atherosclerosis and high specificity expression of the miR-216a in people with unstable atherosclerotic plaque. The invention also discloses the application of the miR-216a and an inhibiting agent in preparation of products for evaluating individual atherosclerotic plaque stability and coronary heart disease occurring risk. The atherosclerotic plaque stability and development are evaluated and predicated by evaluation diagnosis in the early stage of coronary atherosclerosis of the aged through the miR-216a; the miR-216a is of important significance to early treatment and medical cost of coronary atherosclerosis and provides a treatment target and an important basis toclinical applications such as gene therapy and drug therapy.

The invention provides a loose material nematodosis early diagnosis method. The loose material nematodosis early diagnosis method comprises the following steps of collecting a near infrared spectrum of a pine needle of an early stage disease pine tree by using a near infrared spectroscopy, simultaneously collecting a pine needle of a spectrogram of a non-disease pine tree, and establishing a distinguishing model according to two groups of spectrum data; and collecting a spectrogram of the pine needle to be detected, carrying out forecast operation on the spectrogram by using the distinguishing model, and combining a distinguishing threshold value to judge whether the pine tree to be detected gets a disease according to a forecast value. The loose material nematodosis early diagnosis method provided by the invention takes an near infrared spectrum as a core technology, a distinguishing model is rapidly established through a training set sample, the discovery of a pine material nematodiasis of the pine tree is prolonged about ten days, the effective technic instrument is provided for the early diagnosis of the disease, and the abundant time is provided for the treatment of the disease; the loose material nematodosis early diagnosis method provided by the invention has the characteristics that the rapid high efficiency accuracy is high and the like, the early diagnosis of the pine material nematodiasis is realized, and the important technology instrument is provided for the severe damage of the pine tree caused by the early stage discovery, treatment and preventing pine material nematodiasis.

Methods and compositions for the diagnosis and treatment of chronic inflammation (obesity)-induced disorders such as insulin resistance, diabetes, cancer and various metabolic disorders, are provided. The methods and compositions detect both full-blown disease and early stage disease by detecting proteolysis, by neutrophil proteases, of insulin-like growth factor binding protein-3 (IGFBP3). Levels of proteolytic fragments of IGFBP3 and / or levels of intact IGFPB-3 and / or levels / activity neutrophil proteases are detected. Agents (e.g. peptide agents) that inhibit the proteolysis of IGFPB-3 and methods of using the agents to prevent and treat chronic inflammation (obesity)-induced disorders are also provided.

The invention relates to an ecological comprehensive prevention and control method of fig diseases and insect pests. The method comprises early-stage disease and pest control, middle-stage disease andpest control, and late-stage disease and pest control; the front-stage disease and pest control comprises before-sowing, sowing and emergence, and the middle-stage disease and pest control comprisesfertilizer and water management and disease and pest control. Through comprehensive management, according to harm to fig trees by long-horned beetle in different periods, corresponding prevention andcontrol modes are set, so that comprehensive support is provided for disease and pest control of figs, and the problems are solved that the yield of fig trees is reduced and the fruit trees die due tothe fact that diseases and pests endanger the fig trees; the survival rate of the fig trees is guaranteed, the yield of the figs is improved, the economic income of fig planting farmers is increased,the use amount of pesticide is reduced, environmental pollution is reduced, and the ecological environment is protected.

The invention discloses a seed coating agent, which contains the bactericides fludioxonil and difenoconazole and the insecticide dinotefuran as the active components. Specifically, the bactericides fludioxonil and difenoconazole and the insecticide dinotefuran are in a mass ratio of 201:1-1:20, and the balance water. The seed coating agent prepared from the components is subjected to coating according to a drug-seed ratio of 1:2-1:1000, can achieve a very good control effect on earlier stage diseases and pests of wheat, obviously improves the seedling emergence rate, plant height, fresh weightand other indexes, is significantly better than conventional coating agents, is a good coating agent for wheat seeds, and also can be applied to coating of soybeans, corn, potatoes, rice and other crops' seeds and tubers. The coating agent has the characteristics of easily available raw materials, low cost and easy preparation.

The invention provides an eyeball continuity measuring method and an eyeball continuity measuring device. According to the method, the posture of a subject is changed in the measurement process, so that the eyeball scanning instrument can continuously measure the change of physiological parameters or images of eyeballs under different postures of the subject, and the continuous measurement not only comprises the instant variation generated under different postures, but also can comprise the variability of time; therefore, the implicit information amount of the obtained information has diversified characteristics; in addition, the information obtained in the one-time measurement process is much richer than that obtained by a single screenshot mode in the prior art; and the data accumulationis much faster than that in the prior art, so that the establishment of a database platform for big data analysis is facilitated, artificial intelligence deep learning is suitable for analysis, and the discovery of early-stage diseases and the like is facilitated.

The invention discloses a seed coating agent which comprises active components. Active components comprise sterilizing agents and insecticides, the sterilizing agents comprise thifluzamide and tebuconazole, the insecticides comprise clothianidin, the weight ratio of the sterilizing agents to the insecticides is 20:1-1:20, and the rest water. According to the seed coating agent configured by the components, seeds are coated according to the ratio of pesticides to seeds which is 1:2-1:400, the seed coating agent has good preventing effect on earlier stage diseases and insect pests of corns, and indexes such as emergence rate, plant height fresh weight are remarkably improved and obviously better than those of a commonly used coating agent. The seed coating agent is used for corns, low in cost and convenient to prepare and can be applied to coating of crop seeds and tubers such as soybean, wheat, potatoes and rice, and original chemicals of the coating agent are easily obtained.

The invention relates to a conductivity reconstruction method for bioreactor magnetic endoscopic imaging. The conductivity reconstruction method is characterized in that pretreatment including superposed averaging, filter denoising and deconvolution is carried out on original magnetic acoustic signals collected by an ultrasonic detector based on establishment of multi-layer cavity tissue cross-section model; sound source distribution at the cross section of the multi-layer cavity wall tissue is reconstructed by using the pre-processed magnetic acoustic signals; and then according to the obtained sound source distribution, a conductivity distribution graph of the tissue cross section is reconstructed. According to the conductivity reconstruction method, the conductivity distribution graph of the tissue cross section can be constructed accurately and rapidly by using the magnetic acoustic signals generated by biological tissues and thus magnetic-acoustic endoscopic imaging of the biological cavity tissues can be realized, so that accurate and reliable information can be provided for the early-stage disease diagnosis.

A pear tree fruit thinning method comprises disease and insect pest prevention and control, spraying of a fruit thinning agent and artificial thinning supplementation. A compound growth adjusting agent is added to the fruit thinning agent and has the advantages of improving the fruit thinning efficiency, plant disease resistance and fruit safety and saving labor. Early-stage disease and insect pest prevention and control are conducted on tree bodies before fruit thinning, the disease resistance capability of the tree bodies can be improved, tree body diseases caused by adverse factors such as fruit thinning agent spraying and high humidity are avoided, accordingly it is ensured that the tree bodies and fruits healthily grow after fruit thinning, the yield is controlled, and the fruit quality is improved under reasonable load quantity. By utilizing the pear tree fruit thinning method, the fruit thinning speed is 5-10 times higher than artificial fruit thinning speed, the labor number is 1 / 7-1 / 6 of the labor number for artificial fruit thinning, the fruit setting rate is obviously reduced after fruit thinning, the pear tree fruit thinning efficiency is effectively improved, effort-saving tree body and fruit management is achieved, and the existing problems of labor shortage and high labor cost are effectively solved.

The invention relates to an application of chitosan nanogel loaded with oxytocin in preparation of a medicine for early intervention of Alzheimer's disease. The research finds that the chitosan nanogel loaded with oxytocin has a remarkable effect in the aspect of early treatment of the Alzheimer's disease. Cellular level experiment results show that the chitosan nanogel loaded with the oxytocin can inhibit microglial cell activation caused by lipopolysaccharide and reduce expression of inflammatory factors in microglial cells. Animal level experiment results show that the chitosan nanogel loaded with the oxytocin can significantly reduce the expression level of inflammatory factors of hippocampus of an early model mouse with the Alzheimer's disease, significantly reduce beta-amyloid protein deposition and neuron damage, and significantly improve the learning and memory ability of the early model mouse with the Alzheimer's disease. The chitosan nanogel loaded with the oxytocin is simple in preparation process, mild in reaction condition and easy in surface modification.

The invention discloses a Chinese medicinal safflower-astragalus pill for treating leucoderma. The Chinese medicine comprises the following Chinese medicinal components by weight: 150g of sinkiang arnebia root, 150g of dalbergia wood, 150g of paris polyphylla sm., 150g of oriental stephania root, 150g of Japanese ampelopsis root, 150g of peach kernel, 150g of safflower, 60g of Chinese atractylodes, 60g of gentian, 75g of cuttlebone, 105g of liquoric root, 2,250g of tribulus terrestris, 2,250g of malaytea scurfpea fruit, 1,000g of dahurian angelica root and 150g of garter snake. Usage and dosage: the medicaments are ground into fine powder, and the fine powder is prepared into pills with water; and the Chinese medicinal safflower-astragalus pill is taken twice every day, 6-9g every time, and a treatment course lasts for three months. The Chinese medicinal safflower-astragalus pill has the advantages that: the total effective rate on leucoderma is over 95 percent, the curative rate is 90 percent, and the curative rate on early-stage diseases of children is 100 percent. Moreover, the The Chinese medicinal safflower-astragalus pill is free from toxic and side effects.

The invention discloses a health status evaluation system based on deep learning of multidimensional physiological big data, which utilizes a non-supervised convolutional neural network to extract features of physiological time-series data, and then utilizes multivariate Gaussian distribution for feature abnormality detection. The results show that it is an efficient anomaly detection system for physiological signals that can learn high-level features of signals from original physiological signals and multivariate Gaussian distribution anomaly detection. Users can identify certain early symptoms and take corresponding preventive measures in advance to reduce the risk of disease.

The invention relates to an application of miRNA (micro Ribonucleic Acid) in preparation of a medicine for treating an Alzheimer's disease (AD), and the miRNA is composed of one or two of miR-1185-2-3p and miR-107. The invention also relates to an application of the miRNA in preparation of the medicine for treating the Alzheimer's disease (AD), and the miRNA is composed of one or two of miR-1185-2-3p and miR-107. The invention also relates to a corresponding pharmaceutical composition and application thereof. The miRNA has the beneficial effects that the single miRNA and the combination thereof which have relatively high treatment value on AD are found for the first time, so that the possibility of carrying out early treatment on AD pathogenesis in the genetic regulation field is realized, and the early intervention on AD pathogenesis is facilitated.

The invention relates to a preparation method and application of a polypeptide functionalized composite micelle for inhibiting aggregation of alpha-synuclein. The polypeptide functionalized composite micelle is composed of two amphiphilic block copolymers, including a non-physiological environment responsive amphiphilic block copolymer with functionalized polypeptide at a hydrophilic end and an amphiphilic block copolymer with physiological environment responsiveness at a hydrophilic end, and the micelle forms a core-shell-crown structure under physiological conditions. The surface polypeptide specifically recognizes the alpha-synuclein, when the alpha-synuclein tends to gather, the surface polypeptide pulls the alpha-synuclein aggregate to be close to a shell hydrophobic region, so the hydrophobic region efficiently adsorbs the alpha-synuclein aggregate, and the hydrophobic region is divided into independent cells by a hydrophilic end without environmental responsiveness; and the aggregate is prevented from further gathering. The polypeptide functionalized composite micelle is simple in preparation process and good in biocompatibility, can efficiently inhibit alpha-synuclein aggregation, and has a wide application prospect in the aspect of early treatment of Parkinson's disease.

The invention provides a loose material nematodosis early diagnosis method. The loose material nematodosis early diagnosis method comprises the following steps of collecting a near infrared spectrum of a pine needle of an early stage disease pine tree by using a near infrared spectroscopy, simultaneously collecting a pine needle of a spectrogram of a non-disease pine tree, and establishing a distinguishing model according to two groups of spectrum data; and collecting a spectrogram of the pine needle to be detected, carrying out forecast operation on the spectrogram by using the distinguishing model, and combining a distinguishing threshold value to judge whether the pine tree to be detected gets a disease according to a forecast value. The loose material nematodosis early diagnosis method provided by the invention takes an near infrared spectrum as a core technology, a distinguishing model is rapidly established through a training set sample, the discovery of a pine material nematodiasis of the pine tree is prolonged about ten days, the effective technic instrument is provided for the early diagnosis of the disease, and the abundant time is provided for the treatment of the disease; the loose material nematodosis early diagnosis method provided by the invention has the characteristics that the rapid high efficiency accuracy is high and the like, the early diagnosis of the pine material nematodiasis is realized, and the important technology instrument is provided for the severe damage of the pine tree caused by the early stage discovery, treatment and preventing pine material nematodiasis.

The invention discloses a traditional Chinese medicine syndrome identification system for early Parkinson's disease. The system comprises an acquisition module, a recognition module and a prescriptionproviding module, wherein the acquisition module is used for acquiring western medicine clinical symptoms of patients with early Parkinson's disease; the recognition module is used for recognizing traditional Chinese medicine syndrome differentiation types of the patients with early Parkinson's disease based on the western medicine clinical symptoms; and the prescription providing module is usedfor providing a corresponding prescription based on an identified traditional Chinese medicine syndrome differentiation type. According to the invention, the traditional Chinese medicine syndrome identification system for early Parkinson's disease is established, and western medicine neurologists can intelligently match traditional Chinese medicine syndrome differentiation types and correspondingprescriptions by inputting western medicine clinical symptoms of patients with early Parkinson's disease, so the treatment effect of early Parkinson's disease is improved, disease progression is delayed, and the development of combination of traditional Chinese medicine and western medicine in treatment and scientific research of early Parkinson's disease is promoted.