4 results about "Pro calcitonin" patented technology

The application provides a photochemical chemiluminescence detection reagent and a preparation method thereof, and a procalcitonin detection method. The photochemical chemiluminescence detection reagent comprises acceptor microspheres and donor microspheres; wherein the acceptor microspheres are carboxyl-modified acceptor microspheres, and the carboxyl is activated by sulfo-NHS / EDC and coupled with a procalcitonin antibody; and the donor microspheres are carboxyl-modified donor microspheres, and the carboxyl is activated by sulfo-NHS / EDC and coupled with a procalcitonin antibody. The photochemical chemiluminescence detection reagent has higher stability in various environments, can more accurately combine with target molecules, realizes more efficient detection and recognition, and enables the microspheres to more accurately capture and fix the target molecules, so as to perform subsequent luminescence reaction. The detection method has high sensitivity and a wide range, can be used as a detection reagent for diagnosing and identifying infectious diseases of individuals, and has application value.

This invention relates to the field of biomedical data processing technology, specifically to a stratification system for sepsis-related secondary invasive fungal infections based on laboratory data. The invention obtains the degree of static intestinal baseline damage by considering serum lactate concentrations at different historical testing times, temporal characteristics, and a preset maximum backtracking period; it obtains the cumulative dosage of antimicrobial drugs and the hourly cumulative distribution value of drug use based on the drug dosage distribution at different medication times within a neighborhood of the real-time trigger time; it obtains the overall degree of inflammation reduction and the hourly cumulative distribution value of inflammation regression based on the procalcitonin concentration distribution at testing times within a neighborhood; and it further obtains the net drug-induced intervention level. Based on the degree of static intestinal baseline damage and the net drug-induced intervention level, the fungal infection characteristics are stratified. This invention, by considering non-drug-induced interference, accurately obtains the comprehensive risk level of fungal infection, improving the effectiveness of fungal infection stratification.

The application belongs to the technical field of microorganisms, and specifically discloses a fermented Lactobacillus muciapparius BLF03 and application thereof in resisting drug-resistant Staphylococcus aureus. The drug-resistant Staphylococcus aureus is Staphylococcus aureus resistant to drugs targeting beta-lactamase. The fermented Lactobacillus muciapparius BLF03 has been preserved in the China General Microbiological Culture Collection Center on November 6, 2025, and the preservation number is CGMCC No. 36521. The application provides the fermented Lactobacillus muciapparius BLF03 for resisting Staphylococcus aureus resistant to drugs targeting beta-lactamase, which can well relieve infection symptoms induced by drug-resistant Staphylococcus aureus, reduce the expression level of procalcitonin in the body after infection, and improve inflammatory stress response caused by infection, thereby providing a new safe and efficient strain selection for products resisting drug-resistant Staphylococcus aureus.