The invention relates to an intelligent medicine box device for accurately adjusting and controlling patients to take medicines. The intelligent medicine box device comprises a box body, wherein an air distribution plate and an air collecting plate are horizontally arranged in the box body up and down, the interior of the box body is divided into an air distribution area, a medicine storage area and an air collecting area by the air distribution plate and the air collecting plate from top to bottom, a medicine storage unit is arranged in the medicine storage area, a temperature and humidity sensor is arranged in the medicine storage area, an air inlet pipe which is communicated with the air distribution area is arranged on an upper top plate of the box body, the air inlet pipe is connected with a fan and a drying device, another air inlet pipe which is communicated with the air collecting area is arranged on a lower bottom plate of the box body, and the air distribution plate and the air collecting plate are made of pore plates. The temperature and humidity sensor is arranged, so that medicines in a medicine box are guaranteed to be in an optimal storage environment, and the medicine effect is guaranteed. When the patients take medicines each time, all of the medicines in the second medicine box need to be taken out, so that the patients with unclear consciousness can accurately take the medicines, and the phenomena of medicine omission, small dose and large dose cannot occur.