Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for treating ischemic stroke with melatonin

A technology of melatonin and use, applied in the field of use of melatonin in the preparation of medicines for treating ischemic stroke, capable of solving problems such as damage deterioration

Active Publication Date: 2008-01-09
VERSITECH LTD +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Acute thrombolysis or defibrinogenase is feasible in less than 5% of stroke patients and carries considerable risk of conversion from symptomatic hemorrhage to acute infarction
Thus, treatment of hemorrhagic stroke with anti-clot agents is likely to severely worsen the injury

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] The invention discloses a method and a system for timely treating at least one kind of neurological deficit in a subject. The sudden onset of neurological symptoms described above is an indication of a possible stroke, also known as a cerebrovascular accident. The present inventors have discovered that melatonin, a natural substance produced by the pineal gland that is widely used and known to be safe, can protect brain tissue from ischemia-related damage when administered immediately after a stroke of. Since melatonin can be administered safely over a wide range of doses (tested up to at least 50 mg / kg), it may be administered even in cases of suspected stroke.

[0033] Based on laboratory observations, the method comprises administering an effective amount of melatonin to the subject immediately after at least one of the aforementioned neurological deficits occurs, Administer within 3 hours of the defect. Preferably, the effective amount of melatonin is at least ab...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention is directed to a method of treating a sudden onset of at least one neurological deficit in a subject. The sudden onset of neurological symptoms is an indicator of a possible stroke, also termed a cerebrovascular accident. The method comprises administering an effective amount of melatonin to the subject immediately after the sudden onset of at least one neurological deficit, and preferably within three hours of the sudden onset of the at least one neurological deficit. Preferably, the effective amount of melatonin is at least about 200 mg and less than about 1000 mg, although for a small child or infant the effective amount of melatonin may be less than about 200 mg while for a large adult it may be more than about 1000 mg. It is expected that the effective amount of melatonin is no more than about 1500 mg in almost all cases.

Description

[0001] Refer to related applications [0002] This application claims the benefit of US Provisional Application 60 / 443,918, filed January 31,2003. Background of the invention [0003] Stroke is a cardiovascular disease that affects the blood vessels that supply blood to the brain. There are four main types of strokes: two are caused by blood clots or other particles, and two are related to bleeding. By far the most common cause of stroke is cerebral thrombosis and cerebral embolism, caused by blood clots or particles blocking arteries. The other two are caused by cerebral and subarachnoid hemorrhages caused by ruptured blood vessels. [0004] Stroke kills tissue and is the third leading cause of death and the leading cause of disability in developed countries and regions. Typically, a stroke is diagnosed as an ischemic injury to the region, ie, due to lack of oxygen, or due to interruption of blood supply to an area of ​​the brain, when accompanied by neurological or other ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4045A61P9/10A61K31/405A61K31/428A61K38/46A61K49/00
CPCA61K49/0004A61K31/4045A61K31/405A61K31/428A61P9/10
Inventor 张德辉彭树勋
Owner VERSITECH LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com