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Detection of test failure in automatic clinical analyzer

一种临床分析、流体的技术，应用在分析仪领域，能够解决降低设备可靠性、增加成本等问题

Inactive Publication Date: 2008-09-17
ORTHO-CLINICAL DIAGNOSTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This increases cost and further reduces device reliability

Method used

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  • Detection of test failure in automatic clinical analyzer
  • Detection of test failure in automatic clinical analyzer
  • Detection of test failure in automatic clinical analyzer

Examples

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Embodiment Construction

[0029] The present invention relates to a method and apparatus for detecting test failures of analyzers performing clinical analysis. Multiple detection methods are used for the same failure mode. Thus, if a failure is not detected, it must pass through multiple detection systems in series, each with its own probability of detection. The probability of a failure mode being undetected by all these combined detection means is 1 divided by the product of the detection probability of each associated means. The benefit of cascading multiple detection methods for the same failure mode is that each detection method does not have to be very powerful to obtain a robust detection system. At the same time, choosing a combined detection method can prevent functions that are performed correctly from being mistakenly judged as failures.

[0030] In general, the analyzer is first conceptually divided into component systems, and the appropriate component systems are further divided into sub...

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Abstract

The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.

Description

technical field [0001] The present invention relates to analyzers for performing a series of clinical analyses, and in particular to methods for detecting fluid metering failures. Background technique [0002] An automated analyzer is a device used in clinical trials. Much of what used to be a labor-intensive experiment is now handled by loading the sample into the analyzer, programming the analysis to perform the required tests, and then waiting for the results. Use this series analyzer and method a lot now, comprise the absorption analysis of spectrophotometry such as endpoint reaction analysis and reaction rate analysis, turbidity analysis, suspension analysis, radiant energy diffusion analysis (as described in U.S. patent document US4496293 and US4743561 analysis, which is hereby incorporated by reference), ion capture analysis, colorimetric analysis, fluorescence analysis, electrochemical detection system, potential detection system, and immunoassay. All or some of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N37/00G01N35/00G01N33/48G01N35/10
CPCG01N2035/1025G01N35/1016G01N35/00594G01N2035/1018G01N35/10G01N2035/00653G01N35/00603Y10T436/11Y10T436/119163Y10T436/2575G01N35/00
Inventor R·K·波维尔M·阿夫德尼科J·J·达姆布拉M·N·雅各布斯D·D·许德J·D·里尔S·G·麦克唐纳J·D·肖M·A·西蒙
Owner ORTHO-CLINICAL DIAGNOSTICS
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