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Tongkening drip pill used for assistant treating of tumour and its preparation method

A technology of Tongkening dripping pills and adjuvant therapy, which is applied in the direction of antineoplastic drugs, medical raw materials derived from ferns/filamentous plants, and pill delivery, which can solve the problems of long dissolution time, low dissolution rate, and financial burden on patients to avoid gastrointestinal irritation symptoms, accelerate dissolution and absorption, and improve bioavailability

Inactive Publication Date: 2008-10-22
JIANGSU QINGJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the limitations of existing injection preparation technology and the influence of the complexity of traditional Chinese medicine ingredients, traditional Chinese medicine injections are often prone to acute allergic reactions or adverse reactions. At the same time, there are also difficulties in operation, great pain for patients, high manufacturing and medical costs, and inconvenient transportation and storage. , heavy economic burden for patients, unsuitable for family use and other disadvantages
[0008] In addition, due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the drug efficacy. The play also directly affects the therapeutic effect
At the same time, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0031] Now with several groups of specific examples, the preparation method of Tongkening dripping pills of the present invention will be further described.

[0032] [Group 1: Trials with a single substrate]

[0033] 1. Raw materials: according to the preparation method 1, the dry powder containing the active pharmaceutical ingredients of traditional Chinese medicine horsetail and selaginella is prepared in advance for later use;

[0034] 2. Substrate: polyethylene glycol (1000、2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc.;

[0035] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0036] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain Tongkening Dropping Pills of different specifications.

[0037] [test results]

[0038]Experiment 1: In order to obse...

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PUM

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Abstract

A Chinese medicine in the form of dripping pill for the auxiliary therapy to cancer pain is prepared from scouring rush herb, tamariskoid spikemoss herb, and medicinal carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition which has the functions of clearing away heat and detoxifying, dispelling stagnation and dredging collaterals, and is used for adjuvant treatment of malignant tumor pain. A pharmaceutical composition orally prepared. Background technique [0002] According to the formula and extraction process given in the national drug standard WS-10838 (ZD-0838)-2002, Tongkening Injection is a traditional Chinese medicine injection used for the adjuvant treatment of malignant tumor pain. Clinically verified, with stable quality and definite curative effect, it is a common drug used clinically and at home to treat the above diseases. [0003] The following is the formula and extraction process given in the pharmaceutical standard WS-10838 (ZD-0838)-2002: [0004] Prescription: Horsetail 2000g, Selaginella 2000g; [0005] Preparation method: decoct the above two medicinal materials with water twice, the first tim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/11A61P35/00
Inventor 曲韵智
Owner JIANGSU QINGJIANG PHARMA
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