Tongkening drip pill used for assistant treating of tumour and its preparation method
A technology of Tongkening dripping pills and adjuvant therapy, which is applied in the direction of antineoplastic drugs, medical raw materials derived from ferns/filamentous plants, and pill delivery, which can solve the problems of long dissolution time, low dissolution rate, and financial burden on patients to avoid gastrointestinal irritation symptoms, accelerate dissolution and absorption, and improve bioavailability
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[0031] Now with several groups of specific examples, the preparation method of Tongkening dripping pills of the present invention will be further described.
[0032] [Group 1: Trials with a single substrate]
[0033] 1. Raw materials: according to the preparation method 1, the dry powder containing the active pharmaceutical ingredients of traditional Chinese medicine horsetail and selaginella is prepared in advance for later use;
[0034] 2. Substrate: polyethylene glycol (1000、2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc.;
[0035] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;
[0036] 4. Prepare according to the process given in [Preparation Method] 4-7 to obtain Tongkening Dropping Pills of different specifications.
[0037] [test results]
[0038]Experiment 1: In order to obse...
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