Process for preparing Chinese medicine compound injection for treating chronic renal failure and use

A compound injection, renal function technology, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as instability of injections, and achieve the effects of improving stability and solving instability.

Inactive Publication Date: 2009-08-19
杨东 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0033] On the basis of the prior art, the present invention has successfully developed a drug for injection for treating chronic renal failure by combining rhubarb and astragalus. The addition of the two drugs has a synergistic effect, and at the same time, the problem of instability of the injection is solved during the preparation process. Improved stability

Method used

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  • Process for preparing Chinese medicine compound injection for treating chronic renal failure and use
  • Process for preparing Chinese medicine compound injection for treating chronic renal failure and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Take 4500g of Radix Astragali, crush it into coarse particles, add 6 times the amount of water to decoct and extract three times, each time for 1 hour, combine the extracts, filter, add 2% gelatin to the filtrate, stir, filter, and concentrate the filtrate to a relative density of 1.15-1.25 ( (measured at 60°C), add ethanol to make the alcohol content reach 80%, refrigerate for 8 hours, filter, and the filtrate passes through the polyamide resin, and the ethanol is recovered under reduced pressure until there is no alcohol smell, and an appropriate amount of water is added to make the volume of the liquid medicine equal to about 4g / ml, pass D 101 Macroporous resin, first elute with appropriate amount of water, discard the washing liquid, then elute with 30% ethanol until the eluate is nearly colorless, then elute with 50% ethanol, collect ethanol eluate, and recover ethanol under reduced pressure to No alcohol smell, add appropriate amount of water so that the volume of...

Embodiment 2

[0072] Formula composition: Astragalus 450g, rhubarb crude powder 4500g,

[0073] Preparation method: with embodiment 1

Embodiment 3

[0075] Formula composition: Astragalus 4500g, rhubarb crude powder 450g,

[0076] Preparation method: with embodiment 1

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Abstract

The present invention relates to compound Chinese medicine injection, and is especially one kind of compound Chinese medicine injection compounded with rhubarb and astragalus root and its preparation process and application.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection, in particular to a traditional Chinese medicine injection prepared by combining traditional Chinese medicine rhubarb and astragalus. Background technique: [0002] Chronic renal failure (CRF) is an advanced syndrome of renal damage caused by various etiologies. The literature reports that the incidence of CRF accounts for 2%-5% of hospitalized patients and 13.3% of renal hospitalized patients, while the incidence of CRF in patients after cardiac bypass surgery is 4%-15%. Among CRF patients, more than 1 / 3 require dialysis treatment. In the past ten years, with the improvement of diagnosis level, dialysis technology and monitoring quality, great progress has been made in the pathogenesis of CRF and the corresponding prevention and treatment measures proposed accordingly, the mortality rate of CRF is still as high as 30-80% %. [0003] CRF is difficult to treat and the prognosis is ext...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K36/481A61P13/12
Inventor 杨东刘克成杨明均王悦余茹
Owner 杨东
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