Pharmaceutical composition for treating renal failure of diabetic nephropathy as well as preparation method and application of pharmaceutical composition

A technology for diabetic nephropathy and renal function, applied in the field of biomedicine, can solve the problems of few new drugs and few research results of traditional Chinese medicine, and achieve the effect of controllable quality, reasonable composition, and lowering blood creatinine

Pending Publication Date: 2021-04-16
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many studies on the prevention and treatment of diabetic nephropathy and renal failure with traditional Chinese medicine, there are few research results that can obtain evidence-based medical evidence, and there are few new Chinese medicines on the market

Method used

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  • Pharmaceutical composition for treating renal failure of diabetic nephropathy as well as preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the preparation of pharmaceutical composition of the present invention

[0027] Prescription: Astragalus 30g, Rosa laevigata 10g, Ligusticum chuanxiong 10g, Curcuma 10g, Lemon 10g, Gallus gallis 7g, Rhubarb 3g.

[0028] Preparation:

[0029] (1) Take the bulk drug by weight ratio;

[0030] (2) decocting the weighed crude drug with water to obtain a water extract;

[0031] (3) concentrating the water extract, adding pharmaceutically acceptable adjuvants or auxiliary components to obtain a soft material;

[0032] (4) The soft material is sieved and granulated to obtain granules.

Embodiment 2

[0033] Embodiment 2, the preparation of pharmaceutical composition of the present invention

[0034] Prescription: Astragalus 20g, Fructus Rosa 5g, Ligusticum Chuanxiong 5g, Curcuma 5g, Lemon 5g, Gallus gallus 5g, Rhubarb 1g.

[0035] Preparation:

[0036] (1) Take the bulk drug by weight ratio;

[0037] (2) decocting the weighed crude drug with water to obtain a water extract;

[0038] (3) concentrating the water extract, adding pharmaceutically acceptable adjuvants or auxiliary components to obtain a soft material;

[0039] (4) The soft material is sieved and granulated to obtain granules.

Embodiment 3

[0040] Embodiment 3, the preparation of pharmaceutical composition of the present invention

[0041] Prescription: Astragalus 40g, Rosa laevigata 15g, Ligusticum chuanxiong 15g, Curcuma 15g, Lemon 15g, Gallus gallis 10g, cooked rhubarb 5g.

[0042] Preparation:

[0043] (1) Take the bulk drug by weight ratio;

[0044] (2) decocting the weighed crude drug with water to obtain a water extract;

[0045] (3) concentrating the water extract, adding pharmaceutically acceptable adjuvants or auxiliary components to obtain a soft material;

[0046] (4) The soft material is sieved and granulated to obtain granules.

[0047]The beneficial effect of the pharmaceutical composition of the present invention is demonstrated by the following experimental examples.

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Abstract

The invention provides a pharmaceutical composition for treating renal failure of diabetic nephropathy. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 20-40 parts of astragalus membranaceus, 5-15 parts of rosa laevigata michx, 5-15 parts of ligusticum wallichii, 5-15 parts of curcuma zedoary, 5-15 parts of yam rhizome, 5-10 parts of endothelium corneum gigeriae galli and 1-5 parts of cooked rhubarb. The traditional Chinese medicine composition is reasonable in prescription composition, free of toxic medicinal materials, free of incompatibility, capable of effectively reducing serum creatinine of diabetic nephropathy patients and delaying renal failure, capable of being used for clinical treatment of diabetic nephropathy renal failure for a long time, reliable in clinical treatment effect, free of obvious toxic and side effects and adverse reactions in the application process and good in safety. The whole formula is refined in medicine flavor and low in price, the requirement for long-term treatment of the disease can be met, the benefit/risk ratio of clinical application is high, and very high medicinal economic value is achieved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a traditional Chinese medicine composition for treating children with chronic urticaria and / or chronic eczema, a preparation method and application thereof. Background technique [0002] Diabetic nephropathy (Diabetic nephropathy, DN) refers to the kidney disease caused by diabetes. Clinically, it mainly manifests as persistent renal failure. thick. The clinical practice guidelines for diabetes and chronic kidney disease published in the United States in 2007 suggested changing diabetic nephropathy to diabetic kidney disease (Diabetic Kidney Disease, DKD). Diabetic nephropathy caused by kidney biopsy is called Diabetic glomerulopathy if it is confirmed as diabetic nephropathy. DN can occur in both type 1 and type 2 diabetes, and both are related to the course of diabetes. DN has become the first primary disease of chronic renal failure in developed countries, and its inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P3/10A61P13/12A61K35/57
Inventor 李明权向敏赵良斌何玉华王钧冬谢红艳李燕袁强华
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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