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96results about How to "Reduce incompatibility" patented technology

Antagonist of ligands and uses thereof

The invention provides multivalent ligand binding agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. The traps may be used as therapeutic or diagnostic (imaging or non-imaging) agents for diseases / disorders caused by over-production / activity of the target ligand. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, the agent having the general structure I:(<bd1>-linker1)k-[{<bd1>-linker2-<bd2>linker3f-}n-(<bd3>)m-(linker4-<bd4>)d]h,where:n and h are independently greater than or equal to 1;d, f, m and k are independently equal to or greater than zero;bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for the same member of the TGF-β superfamily, with bd1, bd2, bd3, and bd4 being independently the same or different from each other; and,linker1, linker2, linker3 and linker4 are unstructured polypeptide sequences;wherein the number of amino acids in each linker is determined independently and is greater than or equal to X / 2.5; where,X equals the shortest linear distance between:(a) the C-terminus of an isolated form of the binding domain that is located at the N-terminus of the linker and that is specifically bound to its ligand; and,(b) the N-terminus of an isolated form of the binding domain that is located at the C-terminus of the linker and that is specifically bound to its ligand.
Owner:NAT RES COUNCIL OF CANADA

Dexrazoxane freezing-dried powder injection and preparation method thereof

The invention relates to a dexrazoxane freeze-dried powder injection and the preparation method. The preparation is used for resisting the cardiac toxicity which is induced by the cumulate quantity of adriamycin. The dexrazoxane freeze-dried powder injection contains the active components of the dexrazoxane and hydrochloric acid, the weight proportion of which is 1 to 0.05 to 0.5, and the preferential proportion is 1 to 0.2 to 0.5. The preparation method is that the hydrochloric acid is put into an aseptic vessel; the water for injecting is added till 80 percent of the preparation quantity, and the temperature is reduced and kept at 2 to 6 DEG C; the dexrazoxane is added to be mixed, and the hydrochloric acid of 1.0mol/L is dripped slowly into the solution to be solved while mixing the solution; the water for injecting is added till the full quantity; active carbon of 0.3 percent is added for absorbing for thirty minutes, and then the solution is decarbonized; after the medium body content is mensurated as being eligible, the solution is filtered by a 0.22 micron-micropore filtering filer; the filtrate is filled into a 25ml cillin bottle according to the filling quantity of 10ml each bottle, and the bottles are partially plugged by buna plugs and filled onto a plate to be sent into a freeze-drying box; a temperature probe is inserted, and the box door is closed; the filtrate is warmed, sublimed and dried be stages; nitrogen is puffed; the plugs are pressed; the filtrate is taken out from the box for rolling the openings, detecting the quality and packaging and the preparation can be obtained.
Owner:JIANGSU AOSAIKANG PHARMA CO LTD

Fracturing fluid prepared from simulated stratum produced water or stratum produced water

The invention relates to a fracturing fluid used in the technology of fracturing stimulation in oil wells or natural gas wells, and specifically relates to a fracturing fluid prepared from simulated stratum produced water or stratum produced water. The invention is characterized in that: the fracturing fluid comprises a base fluid and a crosslinked fluid, wherein the base fluid accounts for 60% to 99.99% of the total fracturing fluid and the crosslinked fluid accounts for 0.01% to 40.0% of the total fracturing fluid. The base fluid in preparation with simulated stratum produced water comprises: water 91% to 98.9% of the total base fluid, inorganic salt 1% to 8% of the base fracturing fluid, and a thickening agent 0.1% to 1.0% of the total base fluid. The base fluid in preparation with stratum produced water comprises: stratum produced water 99% to 99.9% of the total base fluid, and a thickening agent 0.1% to 1.0% of the total base fluid. The fracturing fluid provided in the invention overcomes the problems that conventional fracturing fluids are easy to deteriorate and cause alkali-sensitivity damage and hydration swelling to understrata, and achieves the purposes of saving resources and reducing damage to strata.
Owner:CHINA NAT PETROLEUM CORP CHUANQING DRILLING ENG CO LTD CHANGQING DOWNHOLE TECH CO
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