The invention relates to a
dexrazoxane freeze-dried
powder injection and the preparation method. The preparation is used for resisting the cardiac
toxicity which is induced by the cumulate quantity of adriamycin. The
dexrazoxane freeze-dried
powder injection contains the
active components of the
dexrazoxane and
hydrochloric acid, the weight proportion of which is 1 to 0.05 to 0.5, and the preferential proportion is 1 to 0.2 to 0.5. The preparation method is that the
hydrochloric acid is put into an aseptic vessel; the water for injecting is added till 80 percent of the preparation quantity, and the temperature is reduced and kept at 2 to 6 DEG C; the dexrazoxane is added to be mixed, and the
hydrochloric acid of 1.0mol / L is dripped slowly into the solution to be solved while mixing the solution; the water for injecting is added till the full quantity;
active carbon of 0.3 percent is added for absorbing for thirty minutes, and then the solution is decarbonized; after the medium body content is mensurated as being eligible, the solution is filtered by a 0.22 micron-micropore filtering filer; the filtrate is filled into a 25ml cillin
bottle according to the filling quantity of 10ml each
bottle, and the bottles are partially plugged by buna plugs and filled onto a plate to be sent into a freeze-
drying box; a temperature probe is inserted, and the box door is closed; the filtrate is warmed, sublimed and dried be stages;
nitrogen is puffed; the plugs are pressed; the filtrate is taken out from the box for rolling the openings, detecting the quality and packaging and the preparation can be obtained.