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Medical use of volatile oil of traditional Chinese medicine

A technology of volatile oil and antitumor drug, applied in the field of medicine

Inactive Publication Date: 2009-09-09
JIANGSU QINGJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Even though the volatile oil of Zangkixiang has shown exciting pharmacological properties, due to the inherent volatility and instability of the volatile oil, it is necessary to choose a reasonable extraction process and preparation to ensure the quality of the drug. In addition, as an anti-tumor drug, it must be With extraordinary stability and uniformity

Method used

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  • Medical use of volatile oil of traditional Chinese medicine
  • Medical use of volatile oil of traditional Chinese medicine
  • Medical use of volatile oil of traditional Chinese medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation of the volatile oil of Akiras sinensis

[0047] Take 20kg of dried Tibetan woody medicinal material, crush it properly, put it into a volatile oil extractor, soak it with 10 times the amount of water for 1 hour, then heat and reflux for extraction for 4 hours, let it stand for 1 hour, and dehydrate it with anhydrous sodium sulfate to get Tibetan wood Aroma volatile oil 170ml, relative density 0.803g / ml at 25°C. GC (Gas Chromatography) method measures wherein the total content of inulin and isoinulin is 47.3%.

Embodiment 2

[0048] Example 2 Preparation of the volatile oil of Akiras sinensis

[0049] Take 20kg of dried Tibetan woody medicinal material, crush it properly, put it into a volatile oil extractor, soak it with 10 times the amount of water for 1 hour, then heat and reflux for extraction for 4 hours, let it stand for 1 hour, and dehydrate it with anhydrous sodium sulfate to get Tibetan wood Fragrance total volatile oil 185ml, relative density 0.810g / ml at 25°C. The total content of inulatin and isoinulalide was 18.5% as measured by GC method.

[0050] Take 50ml of the crude extract of volatile oil of Akira sinensis, take 500g of alumina (100-200 mesh), put it into a glass chromatography column by dry method, put the obtained crude extract of : Ethyl acetate (2:1) was used as the eluent for elution. Combine desired fractions. The solvent was recovered under reduced pressure to obtain 23 g of volatile oil of Zangxiang. The sum of the content of inulin and the content of isocusolide is 3...

Embodiment 3

[0051] Example 3 Preparation of the volatile oil of Akiras sinensis

[0052] Take 50ml of the crude extract of the volatile oil of Akiras sinensis in Example 2, take 500g of silica gel (100-200 mesh), and dry-process it into a glass chromatography column, and put the crude extract of Akiras sinensis obtained on the installed silica gel column, The eluent was eluted with petroleum ether: ethyl acetate (10:1). Combine desired fractions. The solvent was recovered under reduced pressure to obtain 10 g of the volatile oil of Zangxiang. The sum of the contents of inulin and isocusolide is 63.0%.

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Abstract

The present invention relates to a traditional Chinese medicine volatile oil with anti-tumor activity, especially the volatile oil of agaricus argentina and its pharmaceutical composition, and also relates to their preparation method and application as anti-tumor drugs. The invention has the advantages of remarkable antitumor activity and good safety.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to traditional Chinese medicine volatile oil and its preparation, and also includes their preparation technology and anti-tumor medical application; in particular, the volatile oil and its preparation extracted from Tibetan woody fragrance, as well as their preparation technology and anti-tumor medical application. Background technique [0002] Volatile oil of traditional Chinese medicine is a kind of composition with physiological activity, also known as essential oil (essential oil). It is relatively complicated. Clinically, volatile oils have the effects of relieving cough, relieving asthma, eliminating phlegm, sweating, relieving sweating, expelling wind, analgesic, antipyretic, diuretic, invigorating the stomach, antibacterial, disinfecting and killing insects. Some volatile oils have special effects. Physiological effects, such as muskone volatile oil has the effect of stimulating the ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/08A61K9/14A61K9/20A61K9/48A61P35/00A61K125/00
Inventor 杨永安王衡奇徐宏江杨玲张来芳晏彩霞
Owner JIANGSU QINGJIANG PHARMA